Introduction. The authors carried out a comparative analysis of Russian and foreign approaches to regulatory and legal regulation of technologies for industrial treatment of wastewater and its sediments concerning parasitic pathogens. The scientific and applied aspects of introducing domestic lime-containing reagents into disinvasion technology, which can be an alternative to energy-intensive and expensive water treatment methods, have been updated. For consideration by the R.F. Department of water and communal services, the work presents a comparative analysis of Russian and European regulatory and legal acts on the use of reagent compositions of slaked/quicklime in industrial technologies for decontamination and disinfection of sewage and their sediments. Standardization of processes and quality of wastewater disinvasion and its sediments with justification of measures to strengthen hygienic control in the world community of water treatment is updated.

Materials and methods. applied methods of overview, comparative analysis to evaluate the regulatory and legal regulation of technological techniques that ensure parasitocidal efficiency of wastewater treatment and its sediments in industrial water treatment.

Results. The data of full-scale studies of the waters of the surface reservoirs of the Moscow region and the quality of wastewater treatment at discharge points indicate the low efficiency of disinvestment of urban wastewater from centralized wastewater disposal, entering the hydraulic structures of the metropolis and their contribution to the total level of high parasitic pollution of surface water sources.

Conclusion. The analysis of the regulatory regulation of the wastewater treatment and sediments industry showed no development of standardization of wastewater and sediments treatment sub-processes and their complete disinvasion according to parasitic safety criteria. A comparative analysis of measures to enhance hygienic assessment of the quality of cleaning and production of secondary products from formed waste and sediments also showed that preliminary work was done with best available technologies (BAT-5) (information technology support (ITS) 10-2015) on compliance with the sanitary legislation of the Russian Federation, including in terms of legal regulation of standard procedures for the production of by-product (biogas, organic fertilizer, soil, recultivant, etc.) or practically non-hazardous or low-hazard waste intended for placement in the environment.

Introduction. The article is devoted to studying atmospheric air pollution by industrial odours on the health, quality of life, and the occurrence of various somatic and emotional disorders in the population of neighboring residential areas. According to most abroad studies, a literature review showed different conditions mediated by “annoyance” of smell, a “predictor” of deviations in health status.

Material and methods. The data for this study were obtained as a result of the survey of residents of the city with a population of about 50 thousand residents living at different distances from odour sources: coffee factory, bone meal factory, a sugar factory, and solid waste landfill. The distances from the primary sources ranged from 1500 m to > 5 km.

Results. The analysis showed that odour pollution is one of the priority factors affecting residents’ health and quality of life. The frequency and intensity of specific odours in the atmospheric air, according to the results of the survey, decrease as respondents’ place of residence is removed from sources (from 1500 m to > 5 km), as well as the degree of their “annoyance” with odours (from 87.5% to 51.2%), remaining at a very high level at the farthest distances (over 5 km).

Conclusion. Besides to the area of residence and, accordingly, the level of atmospheric air pollution by odours, extent of this “annoyance” can be influenced by concern of residents about possible impact of air pollution, particularly by odours, on health. It has been established that there is a certain category of residents (making up about one-third of the population) who tend to associate their health problems with the state of the environment and, mainly, with the presence of industrial odours. This group of respondents is characterized by a lower tolerance to odours and, at the same time, a higher frequency of upper respiratory tract diseases, allergies, cardiovascular, and some other diseases.

Introduction. The increasing bacterial contamination of water bodies requires an increase in water quality control’s reliability to ensure epidemic safety against waterborne infections. Therefore, researchers in both Russia and Europe came to the conclusion that it is necessary to search for indicator microorganisms that can more accurately suggest the presence of pathogens. microorganisms in water than traditional indicators.

The aim of the study was to justify the introduction of indicator indices of fecal contamination “generalized coliform bacteria” and Escherichia coli to assess the safety of drinking water

Material and methods. The article provides an analysis of domestic and international regulatory documents and literary materials regulating the quality of drinking water in terms of sanitary and microbiological indicators and assessment criteria. The results of many years of experimental and field research carried out by research organizations and practical organizations of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare are presented.

Results. On the territory of Russia, “general coliform bacteria,” is one of the indicator indices chosen according to the fermentation of lactose, determine the safety of drinking water. The water does not take into account pathogenic bacteria (Salmonella, Shigella) and a number of lactose-negative opportunistic bacteria, causative agents of intestinal infections. The study of microorganisms isolated from the feces of patients confirms the frequency of occurrence of lactose-negative microorganisms to varying from 20 to 100% of strains. With an annual trend towards a decrease in the percentage of non-standard drinking water samples in terms of microbiological indices, general intestinal infections (GII) of unknown etiology increase, i.e. risk of GII. If the quality of drinking water does not correspond to thermotolerant coliform bacteria (TCB), 95% of samples contain E. coli. Therefore, the determination of E. coli more reliably indicates the intake of fresh fecal contamination and provides efficiency in taking measures to eliminate an unfavorable situation than TCB.

Conclusion. Reasons are given for the introduction of more reliable microbiological indicators of water safety control, such as - “generalized coliform bacteria” with the preservation of the abbreviation GCB, combining both lactose-positive and lactose-negative bacteria, determined by the sign of glucose fermentation, negative oxidase test and negative stain according to Gram and E. coli as an indicator of recent faecal contamination, which will allow the assessment of water quality for a wide range of bacteria of the order Enterobacterials, corresponding to the modern taxonomy of Enterobacteriaceae NCBI, will ensure harmonization with international requirements and the safety of drinking water for the population.

Introduction. Increased content of organic substances in natural waters, expanding the list of input substances to water bodies, owing to industrial and economic activities of a person, and climate changes is an urgent issue. Against this background, compounds with unknown chemical and toxic properties are likely to appear.

The purpose of this study is to collect data concerning the ways for organic compounds entering water bodies and the human body, study data on interaction mechanisms of organic substances with metals, reveal the fate of known organic chelators, complexing agents as well as organometallic compound shaped by them inside the body. The literature search was carried out in Scopus, Web of Science, CyberLeninka databases.

Sources of organic substances entering water bodies, properties of organic substances. There are three types of organic substances in water bodies, divided by the sources of their occurrence (inflow): terrigenous origin, shaped inside water bodies and coming from man-made sources. Organic compounds may produce soluble and insoluble compounds with metals and colloids.

Mechanisms of interaction of organic substances with metals. Bonding of organic substances takes place by the type of chelation and complexation. There are factors for bonding: functional group content, the molecular mass of substances, ion radius, and competitive interaction with binding sites. Substances having binding properties include phenolic compounds, carboxylic acids, polysaccharides, and flavonoids. Considering that phenolic compounds are located in large quantities in plant and animal tissues, this group of compounds has been researched more thoroughly in terms of interactions with metals and toxicometry.

Intake of organic and organometallic compounds into the body, their kinetics, metabolism and decay. Organic compounds, chelates, and complexes enter the body with drinking water, food, and drugs. They are also generated in the body, including by replacing ions. Data on biochemical and toxicological studies of currently known compounds is given.

Introduction. New cases of pneumoconiosis are detected annually at the bauxite mining enterprises of the Sverdlovsk Region. Differential diagnosis of bauxite pneumoconiosis with other interstitial lung diseases using only lung radiography can be difficult.

The aim of the work was to clarify the nature of changes in the lungs of workers exposed to weakly fibrogenic dust of bauxite, and the relationship of changes in the lungs with working conditions in cases of difficulty in making the final diagnosis of pneumoconiosis.

Material and methods. Underground miners of a working face and underground drifters with a work experience of at least ten years in conditions of exposure to bauxite dust were examined. All patients underwent a plain chest x-ray and high-resolution computed tomography (HRCT), bodyplethysmography, bronchoscopic examination with trans-bronchial biopsy, and subsequent histological examination of the biopsy. To determine the elemental composition of micro- and nanoparticles in biological tissue samples, scanning electron microscopy with X-ray spectral microanalysis was used.

Results. During the histopathological examination of lung tissue biopsy materials by a bright-field method and polarized filter and using electron microscopy, the composition of dust in the lung tissue complied with the composition of industrial aerosol. It is formed during bauxite mining (aluminum, iron, and quartz compounds). High-resolution computed tomography (HRCT) and bronchoscopy can detect signs of exposure to industrial aerosol of complex composition represented by early interstitial parenchymal fibrosis and changes in bronchial mucosa. This is typical for individuals at risk of occupational respiratory diseases development without radiological features specific to pneumoconiosis. Before X-ray pattern formation, typical for pneumoconiosis, bronchitis syndrome and atrophic changes in the bronchial mucosa are developed. This happens in workers exposed to weakly-fibrogenic dust of a complex composition formed during the mining of bauxite.

The changes are permanently observed long after the exposure to the dust factor has ceased.

Introduction. Recent academic studies in the clinic of occupational medicine demonstrate a significant prevalence of cardiovascular and metabolic pathology associated with occupational activity.

Objective. to analyze the role of somatic pathology in occurrence of occupational diseases in aluminum, refractory and asbestos-processing production workers in order to identify the directions of preventive measures.

Material and methods. The results of the examination of aluminum, refractory and asbestos-processing production workers under the periodic medical check-up and in the clinic were analyzed.

Results. According to the periodic medical check-up, only 5.57% of refractory workers, 1.5% of aluminum workers, and 22.7% of asbestos-processing workers were not diagnosed with somatic diseases. Most frequently, workers of the surveyed enterprises reported overweight (up to 68%). lipid storage disease was more likely to occur in the refractory industry (46%), carbohydrate metabolism – in the aluminum industry (22.3%) and asbestos-processing industry (22.6%). In cases with obesity, chronic gastritis, type 2 diabetes, decreased glomerular filtration rate, hyperuricemia, arterial hypertension, and CHD. A considerable influence of somatic pathology on the period of the development of occupational diseases’ has been identified. In patients average work experience before the development of asbestos is reduced from 6 to 12.7 years. In patients with high-grade arterial hypertension, left ventricular myocardial hypertrophy, IHD, overweight and obesity reduction in the average work experience before the development of occupational fluorosis was observed from 3.9 to 6 years. A reduction in the average work experience before the development of silicosis from 10.8 to 13 years was observed in women, as well as in the presence of high-grade arterial hypertension, cardiac arrhythmia and a decrease in blood hemoglobin.

Conclusion. The significant impact of somatic pathology on the terms of the occurrence of occupational diseases in workers of aluminum, asbestos-processing and refractory industries was determined.

Introduction. Protecting consumers’ lives and health in a condition when the number of producers and the variety of food products is continually growing is one of the state’s strategic tasks and the goals of the administrative reform in the Russian Federation.

Material and methods. The work uses methods of analysis, synthesis, comparison, and generalization of the existing in international practice methodological approaches and criteria to assess product safety in planning control and supervision activities, assessing the risk of harm to human health, applied the comparative legal method, methods of mathematical modeling and other methods used when searching legal and analytical research.

Results. A risk-oriented model of control and supervisory activities for food safety is proposed and tested. The model is built under the general principles of the risk assessment methodology and is based on the analysis of the results of previous checks, studies and trials, data from epidemiological studies and relevant scientific literature. The model assumes three successively implemented stages: the categorization (classification) of the economic entity’s activities according to the potential risk of harm to health. Target – to select facilities for the most frequent and in-depth inspections by the supervisory authorities. The second stage is the classification of food products according to the potential risk to consumer health to justify the types of food products subject to priority supervision during scheduled inspections of economic entities. The third stage is constructing “risk profiles” of certain products to optimize laboratory control of food safety.

Discussion. The construction of risk-oriented control based on the principle of step-by-step substantiation and clarification of supervision objects was shown to ensure the targeting of authority and an increase in inspection pressure on precisely those objects that are characterized by the most frequent violations of legal requirements with the most severe and large-scale consequences for health. Increasing the control density at the highest risk categories’ facilities does not require additional resources from the regulator. It is still implemented by removing facilities with moderate or low risk from planned supervision and optimizing laboratory support.

Conclusion. Work out and implement a risk-based food safety surveillance model corresponds to the strategic vector of development of state control (supervision) in the Russian Federation. The system assumes that “risky” goods are unsafe for the consumer’s health. Accordingly, their producers, distributors, and sellers should be under robust inspection, including laboratory supervision, and precisely according to those indicators for which these risks are most significant. The system is in a dynamic state and development.

According to the federal law «Formation of a system for motivating citizens to a healthy lifestyle, including healthy eating and giving up bad habits» (or «Strengthening public health») which is a part of «Demography» National project, there is a work needed for healthy food’s popularization including the development and realization of unique educational programs dedicated to rational and balanced nutrition.

The aim of the investigation is a discussion of approaches to implementation target educational healthy nutrition programs. The scientific and educational centers of healthcare institutions and Federal Service for Supervision of Consumer Rights Protection and Human Welfare scientific organizations took part in developing the academic programs. Eight target programs were designed such as for preschool children, for pregnant and lactating women; for persons over working age; for persons with an increased level of physical activity; for the population working in hazardous and challenging working conditions; for people living in regions with specific environmental factors (micro-and macronutrients insufficiency, climate conditions). The development of interaction between particular departments of regional executive authority that take part in regional programs for implementing federal law «Strengthening public health» ministries or departments of the education and healthcare system is needed for reaching declared goals for the were educating the population on relevant knowledge and skills. The distribution of health nutrition educational program’s materials should be started among pupils in educational organizations considering the children’s physiologically determined learning ability. The projected difficulties can be the next: staff insufficiency in Federal Service for Supervision of Consumer Rights Protection and Human Welfare local authorities and organizations; lack of creativity during the choosing of using methods; the passivity of other ministries and departments; insufficient technical equipment in educational organizations; psychological resistance to innovations.

Healthy nutrition is an essential component of a person’s quality of life, mental, physical, and social functioning. Russians’ diet is not enough vegetables and fruits, dairy products, excess sugar, salt, products containing animal fat, and TRANS fats. Violations of nutrition structure and nutritional status lead to the development of alimentary-dependent diseases (cardiovascular, oncological, diabetes, obesity, gout, osteoporosis, etc.) - the leading causes of death in the population. All this indicates a low level of knowledge of the people about the principles of healthy nutrition. 49.2% of Russians have almost no idea about the rules of healthy eating. It is imperative to eliminate the existing gap in the education of the population on healthy nutrition by introducing training programs. For this purpose, training (educational) programs on healthy food have been developed for target groups of the population (preschool and school-age children; adults of all ages, including pregnant and nursing women, people older than working age; people with an increased level of physical activity; working in difficult and harmful working conditions; living in territories with unique features in terms of the impact of environmental factors). On the basis Federal Research Centre of Nutrition, Biotechnology and Food Safety created scientific-methodical and educational centers on issues of healthy nutrition for the development of training (education) programs, Center for hygienic education of the population”, issued an Order from Rospotrebnadzor 24.03.2020, № 186 “On approval of the concept of creating a training (educational) programs on healthy nutrition”.

Introduction. Universities start their education in their associated pre-universities using University principles of education and modern technologies. The study of the impact of specialized medical training on senior high school students, and the justification of approaches to the hygienic assessment of modern technologies for their specialized training is relevant.

Material and methods. The study based on the pre-University of Sechenov University, attended by 181 students aged 15-17 years. The assessment of the psychophysiological status of students was performed using specialized questionnaires (Klimov, Kettel, Schulte, Munsterberg, Spielberg-Hannin, SAN). Physiological methods included the assessment of indices: CFFF, RBD, tremorometry.

Results. Specialized medical training exceeds the weekly training load-38-40 hours. Individual project activities are allocated 20 hours per week. Simulation classes are held once a week for 90 minutes with a 5-minute break in the middle. The schedule of classes corresponds to the physiological performance curve. The duration of homework exceeds hygiene standards in 69.2% of students. Among the students, only one in four has a tendency to work in the “person – to-person” system. Mental performance, indices of CSCM, RDO of students in the dynamics of the school day are stable. Indices of tremorometry in simulation classes are stable and indicate a good state of coordination capabilities of the hands. In simulation activities, 53.5% of students have higher-than-average activity, which is 1.4 times more than in a traditional lesson. All students are characterized by a high level of anxiety in all types of educational activities.

Conclusion. Training using design and research, digital, simulation, and phantom technologies is adequate to the physiological capabilities of the body of students and can be recommended for the use in medical profile training. Hygienic examination of technologies of profile training of pupils should be based on a comprehensive approach, including assessment of psychophysiological status of students, and also indices of a psychofunctional state students during the lessons.

Introduction. The literature analysis of structural and functional indices clearly shows no scientifically based set of quantitative indices. It fails to allow statistical data processing and makes it challenging to assess various levels of impact objectively.

The goal was to analyze the literature to select structural and functional criteria-significant indicators and develop their quantitative and point assessment.

Material and methods. Based on the literature review, the authors identified indices on the analysis of the histological picture. We developed quantitative morphometric, stereometric, and point scores for various systems of the body including the heart and vascular state in the organs under investigation, small and large intestine, stomach, liver, pancreas, adrenal and thyroid, glands, lungs and bronchi, kidney, testis, spleen, thymus. There were used microscopes with the ability to transmit images to a computer screen display. Authors analyzed 6-month oral exposure of the pesticide carbamate class in doses of 2.5, 5.0, and 20 mg/kg.

Results. Based on the literature review, significant structural and functional criteria indices were selected. Authors developed a quantitative assessment for them. For each body, a table is proposed to allow digital input data about indices and their statistical processing. When analyzing the effects of the pesticide on rats at a dose of 20 mg/kg, target organs were identified: the liver, which develops both damage responses and compensatory alterations, and the stomach, which is a violation of the structure of the organ. Moreover, a trend towards changes in the indices in the lungs and colon was also noted. The pesticide doses of 5 and 2.5 mg/kg for these indices of the studied organs were invalid.

Conclusion. Quantitative structural and functional indices for the cardiovascular, digestive, pulmonary, excretory, endocrine, immune, and reproductive systems of rats were developed to assess toxic effects.

Introduction. In recent years, agricultural production in Russia has increased at the expense of farms and personal subsidiary plots; farmers use chemical protection means - pesticides to protect crops. Farmers and users of private household plots are considered the leading risk group most exposed to pesticides during their application, transportation, and loading. At the same time, farmers and users do not have special training in the safe handling of pesticides. They do not undergo periodic medical examinations, which increases the risk of exposure to pesticides on their health.

Purpose of work. Study of exposures of pesticides in the air of the working area and on the skin of workers when they use pesticides in private farms, farms on-field, and high garden crops; justification of the requirements for the safe use of pesticides in private farms and farms.

Material and methods. The established exposure levels of pesticides in the air and on the skin were compared with hygiene standards calculated or experimentally set: MPC / OBUV (mg/m³) in the atmosphere of the working area and MPC/ODU (mg/cm²) of skin contamination. The exposure level risk was determined by the KBsumm. The risk of exposure to pesticides for the operator/farmer/user based on the absorbed dose, determined by the value of the safety factor – KBp, and exposure – Kbsumm, is considered acceptable when the value of KBsumm and KBp < 1.

Results. The authors presented generalized results of the analysis of the risk of exposure to pesticides in terms of both exposure (KBsumm) and absorbed dose (KBp) in natural conditions when using 20 drugs on field and garden crops in private household plots and farms. The absorbed dose for farmers, calculated taking into account the work for 6 hours, when compared with ADI, in some cases, exceeded the permissible values. The risk of using two preparations in suspension concentrates and one preparation in the form of a nanoemulsion concentrate in terms of the absorbed dose during knapsack spraying of field crops in farms was higher than the acceptable one.

Conclusion. The hygienic assessment of the risk of using pesticides of different hazard classes for all land application methods into the environment convinces us the actual hygienic situation to be determined mainly by the state of the equipment used, compliance with hygiene regulations. The degree of professional skills of operators, as well as the culture of pesticide use, are significant. In the future, the risk, especially in terms of the absorbed dose, must be calculated for users of private household plots and farmworkers, taking into account the differences in cultivated areas’ volumes.

4 декабря 2020 года исполнилось 95 лет Заслуженному деятелю науки Российской Федерации, крупному российскому учёному в области медико-биологических наук, доктору медицинских наук, профессору, главному научному сотруднику, руководителю «Уральского центра восстановительной медицины и курортологии» ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора Игорю Евгеньевичу Оранскому.