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Clinical effectiveness of combined phototherapy in the treatment of patients with atopic dermatitis
- Authors: Kruglova L.S.1, Novikova L.A.2, Borzunova L.N.2, Dontsova E.V.2, Voron'kova N.A.2
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Affiliations:
- Central State Medical Academy of Department of Presidential Affairs
- Voronezh State Medical University
- Issue: Vol 19, No 4 (2020)
- Pages: 239-243
- Section: Original studies
- URL: https://rjpbr.com/1681-3456/article/view/65109
- DOI: https://doi.org/10.17816/1681-3456-2020-19-4-6
- ID: 65109
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Abstract
Background. Due to the insufficient effectiveness of currently known methods of treating patients with atopic dermatitis (ATD), there is a need to find new approaches to solve this problem.
Aims: The study was conducted in order to study the possibility of improving the effectiveness of basic therapy for patients with ATD using combined phototherapy (FT) of narrow-band medium-wave and wide-band long-wave ultraviolet (UV) radiation.
Materials and methods. In a group of 62 patients (average age 24.1 ± 6.1 years), a comparative assessment of the effectiveness of ATD basic drug therapy (BT) and complex treatment using combined FT of narrow-band medium-wave (311 nm) and wide-band long-wave radiation in the range of 320–400 nm was performed.
Results. When using BT and combined FT (CFT) together, there is a potentiation of the clinical effects of the used therapeutic methods. The reduction in the relative risk of the disease recurrence in the СFT + BT group (compared to the BT group) during the year of follow-up was 42%.
Conclusion. The developed method of treatment using combined phototherapy provides a more effective reduction in the severity of skin manifestations of ATD according to the SCORAD index by 34.2% and an improvement in the quality of life by 43.5%, as well as a reduction in the relative risk of the disease recurrence by 42% compared to the results of basic drug therapy.
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About the authors
Larisa S. Kruglova
Central State Medical Academy of Department of Presidential Affairs
Email: ledn89@mail.ru
SPIN-code: 1107-4372
DSc., Prof
Russian Federation, MoscowLyubov' A. Novikova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0003-3465-8348
SPIN-code: 5445-2961
DSc
Russian Federation, VoronezhLarisa N. Borzunova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0001-8606-9006
SPIN-code: 8779-5108
PhD
Russian Federation, VoronezhElena V. Dontsova
Voronezh State Medical University
Author for correspondence.
Email: ledn89@mail.ru
ORCID iD: 0000-0001-6119-2120
SPIN-code: 5227-3284
DSc
Russian Federation, VoronezhNatalya A. Voron'kova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0003-3716-233X
SPIN-code: 6282-6453
Russian Federation, Voronezh
References
- Kubanov AA, Bogdanova EV. Dermatovenereologic health care delivery management in the Russian Federation. Results of 2018. Dermatology and Venereology Bulletin. 2019;95(4):8–23. (In Russ). doi: 10.25208/0042-4609-2019-95-4-8-23
- Psomadakis CE, Han G. New and emerging topical therapies for psoriasis and atopic dermatitis. J Clin Aesthet Dermatol. 2019;12:28–34.
- Kruglova LS. Broadband medium-long-wave phototherapy in the treatment of patients with atopic dermatitis. Bulletin of the Russian State Medical University. 2007;(6):55–62. (In Russ).
- Fernández-Guarino M, Aboin-Gonzalez S, Barchino L, et al. Treatment of moderate and severe adult chronic atopic dermatitis with narrow-band UVB and the combination of narrow-band UVB/UVA phototherapy. Dermatol Ther. 2016;29(1):19–23. doi: 10.1111/dth.12273
- Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Dermatol Venereol. 1980;92(1):44–47.
- Korostovcev DS, Makarova IV, Revjakina VA, et al. SCORAD Index – an objective and standardized method for assessing skin lesions in atopic dermatitis. Allergology. 2000;(3):39–43. (In Russ).
- Kochergin NG. Osnovnye aspekty patogeneza, kliniki i sovremennoi terapii atopicheskogo dermatita. [dissertation abstract] Moscow; 2001. 30 р. (In Russ).
- Olisova OYu, Vladimirov VV, Murakhovskaya EK. UVA 370 nm phototherapy of atopic dermatitis. Russian Journal of Skin and Venereal Diseases. 2013;(6):22–27. (In Russ).
- Kosheleva IV, Khasanova AR. Modern therapeutic approaches to atopic dermatitis: the role of phototherapy and the search for new ways. Lechashchii vrach. 2018;(4):24–26. (In Russ).
- Оrtiz-Salvador JM, Pérez-Ferriols A. Phototherapy in atopic dermatitis. Adv Exp Med Biol. 2017;996:279–286. doi: 10.1007/978-3-319-56017-5_23
- Patrizi A, Raone B, Ravaioli GM. Management of atopic dermatitis: safety and efficacy of phototherapy. Clin Cosmet Investig Dermatol. 2015;8:511–520. doi: 10.2147/CCID.S87987
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