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Clinical effectiveness of combined phototherapy in the treatment of patients with atopic dermatitis
- Authors: Kruglova L.S. 1, Novikova L.A. 2, Borzunova L.N. 2, Dontsova E.V. 2, Voron'kova N.A. 2
- Affiliations:
- Central State Medical Academy of Department of Presidential Affairs
- Voronezh State Medical University
- Issue: Vol 19, No 4 (2020)
- Pages: 239-243
- Section: Original studies
- URL: https://rjpbr.com/1681-3456/article/view/65109
- DOI: https://doi.org/10.17816/1681-3456-2020-19-4-6
- Cite item
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Abstract
Background. Due to the insufficient effectiveness of currently known methods of treating patients with atopic dermatitis (ATD), there is a need to find new approaches to solve this problem.
Aims: The study was conducted in order to study the possibility of improving the effectiveness of basic therapy for patients with ATD using combined phototherapy (FT) of narrow-band medium-wave and wide-band long-wave ultraviolet (UV) radiation.
Materials and methods. In a group of 62 patients (average age 24.1 ± 6.1 years), a comparative assessment of the effectiveness of ATD basic drug therapy (BT) and complex treatment using combined FT of narrow-band medium-wave (311 nm) and wide-band long-wave radiation in the range of 320–400 nm was performed.
Results. When using BT and combined FT (CFT) together, there is a potentiation of the clinical effects of the used therapeutic methods. The reduction in the relative risk of the disease recurrence in the СFT + BT group (compared to the BT group) during the year of follow-up was 42%.
Conclusion. The developed method of treatment using combined phototherapy provides a more effective reduction in the severity of skin manifestations of ATD according to the SCORAD index by 34.2% and an improvement in the quality of life by 43.5%, as well as a reduction in the relative risk of the disease recurrence by 42% compared to the results of basic drug therapy.
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About the authors
Larisa S. Kruglova
Central State Medical Academy of Department of Presidential Affairs
Email: ledn89@mail.ru
SPIN-code: 1107-4372
Russian Federation, Moscow
DSc., Prof
Lyubov' A. Novikova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0003-3465-8348
SPIN-code: 5445-2961
Russian Federation, Voronezh
DSc
Larisa N. Borzunova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0001-8606-9006
SPIN-code: 8779-5108
Russian Federation, Voronezh
PhD
Elena V. Dontsova
Voronezh State Medical University
Author for correspondence.
Email: ledn89@mail.ru
ORCID iD: 0000-0001-6119-2120
SPIN-code: 5227-3284
Russian Federation, Voronezh
DSc
Natalya A. Voron'kova
Voronezh State Medical University
Email: ledn89@mail.ru
ORCID iD: 0000-0003-3716-233X
SPIN-code: 6282-6453
Russian Federation, Voronezh
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Supplementary files
| Supplementary Files | Action | ||
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Fig. 1. Dynamics of the SCORAD index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment).
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| 2. |
Fig. 2. Dynamics of the DIKI index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment)
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Fig. 3. Average number of relapses per year in patients with AD with different types of treatment.
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