Clinical effectiveness of combined phototherapy in the treatment of patients with atopic dermatitis

Cover Page
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Background. Due to the insufficient effectiveness of currently known methods of treating patients with atopic dermatitis (ATD), there is a need to find new approaches to solve this problem.

Aims: The study was conducted in order to study the possibility of improving the effectiveness of basic therapy for patients with ATD using combined phototherapy (FT) of narrow-band medium-wave and wide-band long-wave ultraviolet (UV) radiation.

Materials and methods. In a group of 62 patients (average age 24.1 ± 6.1 years), a comparative assessment of the effectiveness of ATD basic drug therapy (BT) and complex treatment using combined FT of narrow-band medium-wave (311 nm) and wide-band long-wave radiation in the range of 320–400 nm was performed.

Results. When using BT and combined FT (CFT) together, there is a potentiation of the clinical effects of the used therapeutic methods. The reduction in the relative risk of the disease recurrence in the СFT + BT group (compared to the BT group) during the year of follow-up was 42%.

Conclusion. The developed method of treatment using combined phototherapy provides a more effective reduction in the severity of skin manifestations of ATD according to the SCORAD index by 34.2% and an improvement in the quality of life by 43.5%, as well as a reduction in the relative risk of the disease recurrence by 42% compared to the results of basic drug therapy.

Full Text

Restricted Access

About the authors

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs

SPIN-code: 1107-4372

Russian Federation, Moscow

DSc., Prof

Lyubov' A. Novikova

Voronezh State Medical University

ORCID iD: 0000-0003-3465-8348
SPIN-code: 5445-2961

Russian Federation, Voronezh


Larisa N. Borzunova

Voronezh State Medical University

ORCID iD: 0000-0001-8606-9006
SPIN-code: 8779-5108

Russian Federation, Voronezh


Elena V. Dontsova

Voronezh State Medical University

Author for correspondence.
ORCID iD: 0000-0001-6119-2120
SPIN-code: 5227-3284

Russian Federation, Voronezh


Natalya A. Voron'kova

Voronezh State Medical University

ORCID iD: 0000-0003-3716-233X
SPIN-code: 6282-6453

Russian Federation, Voronezh


  1. Kubanov AA, Bogdanova EV. Dermatovenereologic health care delivery management in the Russian Federation. Results of 2018. Dermatology and Venereology Bulletin. 2019;95(4):8–23. (In Russ). doi: 10.25208/0042-4609-2019-95-4-8-23
  2. Psomadakis CE, Han G. New and emerging topical therapies for psoriasis and atopic dermatitis. J Clin Aesthet Dermatol. 2019;12:28–34.
  3. Kruglova LS. Broadband medium-long-wave phototherapy in the treatment of patients with atopic dermatitis. Bulletin of the Russian State Medical University. 2007;(6):55–62. (In Russ).
  4. Fernández-Guarino M, Aboin-Gonzalez S, Barchino L, et al. Treatment of moderate and severe adult chronic atopic dermatitis with narrow-band UVB and the combination of narrow-band UVB/UVA phototherapy. Dermatol Ther. 2016;29(1):19–23. doi: 10.1111/dth.12273
  5. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Dermatol Venereol. 1980;92(1):44–47.
  6. Korostovcev DS, Makarova IV, Revjakina VA, et al. SCORAD Index – an objective and standardized method for assessing skin lesions in atopic dermatitis. Allergology. 2000;(3):39–43. (In Russ).
  7. Kochergin NG. Osnovnye aspekty patogeneza, kliniki i sovremennoi terapii atopicheskogo dermatita. [dissertation abstract] Moscow; 2001. 30 р. (In Russ).
  8. Olisova OYu, Vladimirov VV, Murakhovskaya EK. UVA 370 nm phototherapy of atopic dermatitis. Russian Journal of Skin and Venereal Diseases. 2013;(6):22–27. (In Russ).
  9. Kosheleva IV, Khasanova AR. Modern therapeutic approaches to atopic dermatitis: the role of phototherapy and the search for new ways. Lechashchii vrach. 2018;(4):24–26. (In Russ).
  10. Оrtiz-Salvador JM, Pérez-Ferriols A. Phototherapy in atopic dermatitis. Adv Exp Med Biol. 2017;996:279–286. doi: 10.1007/978-3-319-56017-5_23
  11. Patrizi A, Raone B, Ravaioli GM. Management of atopic dermatitis: safety and efficacy of phototherapy. Clin Cosmet Investig Dermatol. 2015;8:511–520. doi: 10.2147/CCID.S87987

Supplementary files

Supplementary Files Action
Fig. 1. Dynamics of the SCORAD index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment).

Download (187KB) Indexing metadata
Fig. 2. Dynamics of the DIKI index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment)

Download (183KB) Indexing metadata
Fig. 3. Average number of relapses per year in patients with AD with different types of treatment.

Download (87KB) Indexing metadata



Abstract - 44

PDF (Russian) - 0


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2020 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies