Clinical effectiveness of combined phototherapy in the treatment of patients with atopic dermatitis

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Abstract


Background. Due to the insufficient effectiveness of currently known methods of treating patients with atopic dermatitis (ATD), there is a need to find new approaches to solve this problem.

Aims: The study was conducted in order to study the possibility of improving the effectiveness of basic therapy for patients with ATD using combined phototherapy (FT) of narrow-band medium-wave and wide-band long-wave ultraviolet (UV) radiation.

Materials and methods. In a group of 62 patients (average age 24.1 ± 6.1 years), a comparative assessment of the effectiveness of ATD basic drug therapy (BT) and complex treatment using combined FT of narrow-band medium-wave (311 nm) and wide-band long-wave radiation in the range of 320–400 nm was performed.

Results. When using BT and combined FT (CFT) together, there is a potentiation of the clinical effects of the used therapeutic methods. The reduction in the relative risk of the disease recurrence in the СFT + BT group (compared to the BT group) during the year of follow-up was 42%.

Conclusion. The developed method of treatment using combined phototherapy provides a more effective reduction in the severity of skin manifestations of ATD according to the SCORAD index by 34.2% and an improvement in the quality of life by 43.5%, as well as a reduction in the relative risk of the disease recurrence by 42% compared to the results of basic drug therapy.


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About the authors

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs

Email: ledn89@mail.ru
SPIN-code: 1107-4372

Russian Federation, Moscow

DSc., Prof

Lyubov' A. Novikova

Voronezh State Medical University

Email: ledn89@mail.ru
ORCID iD: 0000-0003-3465-8348
SPIN-code: 5445-2961

Russian Federation, Voronezh

DSc

Larisa N. Borzunova

Voronezh State Medical University

Email: ledn89@mail.ru
ORCID iD: 0000-0001-8606-9006
SPIN-code: 8779-5108

Russian Federation, Voronezh

PhD

Elena V. Dontsova

Voronezh State Medical University

Author for correspondence.
Email: ledn89@mail.ru
ORCID iD: 0000-0001-6119-2120
SPIN-code: 5227-3284

Russian Federation, Voronezh

DSc

Natalya A. Voron'kova

Voronezh State Medical University

Email: ledn89@mail.ru
ORCID iD: 0000-0003-3716-233X
SPIN-code: 6282-6453

Russian Federation, Voronezh

References

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Supplementary files

Supplementary Files Action
1.
Fig. 1. Dynamics of the SCORAD index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment).

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2.
Fig. 2. Dynamics of the DIKI index in the compared groups during treatment (before treatment, after 1 and 3 months from the start of treatment)

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3.
Fig. 3. Average number of relapses per year in patients with AD with different types of treatment.

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