Balneotherapy as a promising method for the correction of dermatologic adverse events of cancer therapy

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Abstract

Cancer treatment with chemotherapy, targeted and immunotherapy is associated with a wide spectrum of dermatologic adverse events. Xerosis (dryness) of the skin is the most prevalent skin side effect in oncologic patients, which occurs both during treatment with "classic" chemotherapy drugs and modern cancer drugs, such as targeted therapy and immunotherapy.

Despite the high prevalence of this side effect, current approaches to the correction of skin xerosis in cancer patients are very limited. At the same time, in the absence of adequate supportive treatment of xerosis, the formation of persistent fissures, eczematization and secondary infection is observed, which may lead to antitumor therapy regimen modification. Thus, optimization of prophylactic and treatment strategies for xerosis in patients treated with anticancer drugs remain an important interdisciplinary problem. Balneotherapy is a promising method for the correction of skin xerosis due to a complex positive effect on the level of skin hydration, a decrease in the intensity of inflammatory processes, a beneficial effect on the state of the skin barrier function, as well as an increase in antimicrobial protection. Available data on the use of balneotherapy in the supportive treatment of skin xerosis as a dermatological adverse event of anticancer therapy confirms the high efficacy and safety, as well as good tolerability of this method in cancer patients.

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About the authors

Aleksandra S. Polonskaia

Central State Medical Academy of the Office of the President of the Russian Federation

Author for correspondence.
Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0001-6888-4760
SPIN-code: 8039-4105

MD, Postgraduate Student

Russian Federation, Moscow

Evgeniya A. Shatokhina

Central State Medical Academy of the Office of the President of the Russian Federation; Medical Research and Education Center of Lomonosov Moscow State University

Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0002-0238-6563
SPIN-code: 3827-0100

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Larisa S. Kruglova

Central State Medical Academy of the Office of the President of the Russian Federation

Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265
SPIN-code: 1107-4372

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

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Supplementary files

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1. JATS XML
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2. Fig. 1. Xerosis cutis of the right arm, associated with cancer therapy. Lichenification, white small scales on the skin surface, erythema.

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3. Fig. 2. Upper back xerosis cutis, associated with targeted cancer therapy with gefitinib (epidermal growth factor receptor inhibitor). Lichenification, white small scales on the skin surface, pinpoint and linear excoriations.

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