Russian Journal of Physiotherapy, Balneology and RehabilitationRussian Journal of Physiotherapy, Balneology and RehabilitationФизиотерапия, бальнеология и реабилитация1681-34562413-2969Eco-Vector10802610.17816/rjpbr108026Guidelines for practitionersВ помощь практическому врачуResearch ArticleBalneotherapy as a promising method for the correction of dermatologic adverse events of cancer therapyБальнеотерапия как перспективный метод коррекции дерматологических нежелательных явлений противоопухолевого леченияhttps://orcid.org/0000-0001-6888-47608039-4105PolonskaiaAleksandra S.ПолонскаяАлександра Сергеевна
Russian Federation

MD, Postgraduate Student

аспирант

dr.polonskaia@gmail.comhttps://orcid.org/0000-0002-0238-65633827-0100ShatokhinaEvgeniya A.ШатохинаЕвгения Афанасьевна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

dr.polonskaia@gmail.comhttps://orcid.org/0000-0002-5044-52651107-4372KruglovaLarisa S.КругловаЛариса Сергеевна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

kruglovals@mail.ruCentral State Medical Academy of the Office of the President of the Russian FederationЦентральная государственная медицинская академия Управления делами Президента Российской ФедерацииMedical Research and Education Center of Lomonosov Moscow State UniversityМедицинский научно-образовательный центр Московского государственного университета имени М.В. Ломоносова150920212065515581805202208062022Copyright ©; 2021, Eco-VectorCopyright ©; 2021, ООО "Эко-Вектор"2021Eco-VectorООО "Эко-Вектор"https://rjpbr.com/1681-3456/article/view/108026

Cancer treatment with chemotherapy, targeted and immunotherapy is associated with a wide spectrum of dermatologic adverse events. Xerosis (dryness) of the skin is the most prevalent skin side effect in oncologic patients, which occurs both during treatment with "classic" chemotherapy drugs and modern cancer drugs, such as targeted therapy and immunotherapy.

Despite the high prevalence of this side effect, current approaches to the correction of skin xerosis in cancer patients are very limited. At the same time, in the absence of adequate supportive treatment of xerosis, the formation of persistent fissures, eczematization and secondary infection is observed, which may lead to antitumor therapy regimen modification. Thus, optimization of prophylactic and treatment strategies for xerosis in patients treated with anticancer drugs remain an important interdisciplinary problem. Balneotherapy is a promising method for the correction of skin xerosis due to a complex positive effect on the level of skin hydration, a decrease in the intensity of inflammatory processes, a beneficial effect on the state of the skin barrier function, as well as an increase in antimicrobial protection. Available data on the use of balneotherapy in the supportive treatment of skin xerosis as a dermatological adverse event of anticancer therapy confirms the high efficacy and safety, as well as good tolerability of this method in cancer patients.

Лекарственная противоопухолевая терапия ассоциирована с развитием широкого спектра дерматологических нежелательных явлений. Ксероз (сухость) является самым распространённым побочным эффектом со стороны кожи у онкологических пациентов и наблюдается при лечении как классическими химиотерапевтическими, так и современными противоопухолевыми препаратами таргетной и иммунотерапии. Несмотря на широкую распространённость данного нежелательного явления, подходы к коррекции ксероза кожи у онкологических пациентов на сегодняшний день носят весьма ограниченный характер. В то же время при отсутствии адекватного сопроводительного лечения ксероза наблюдается формирование стойких трещин, экзематизации и очагов вторичного инфицирования, что может стать причиной модификации режима противоопухолевой терапии. Таким образом, оптимизация методов профилактики и лечения ксероза кожи у пациентов онкологического профиля остаётся актуальной задачей. Наружная бальнеотерапия представляет собой перспективный метод коррекции ксероза, что обусловлено комплексным положительным воздействием на уровень увлажненности и состояние барьерной функции кожи, снижением интенсивности воспалительных процессов и усилением противомикробной защиты. Имеющиеся данные о применении бальнеотерапии в лечении ксероза кожи как дерматологического нежелательного явления противоопухолевой терапии подтверждают высокую эффективность и безопасность, а также хорошую переносимость данного метода у онкологических пациентов.

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