Information-predictive approach to evaluation of the efficiency of treatment of chronic generalized periodontitis using non-drug technologies ABSTRACT

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Abstract

BACKGROUND: The information-predictive approach can be used for determining biomarkers as predictors that allow predicting the effectiveness of the treatment of chronic generalized periodontitis using the combined use of ozone and transcranial magnetotherapy.

AIMS: Determination of the set of initial morphometric parameters that have predictive significance, as well as the development of a method for the integral assessment of the clinical effectiveness of the combined use of ozone and transcranial magnetotherapy in patients with chronic generalized periodontitis.

MATERIALS AND METHODS: A multiple regression model was built, which establishes the relationship between the dependent variable (effective sign — treatment effectiveness) and the value of independent variables (factors characterizing the initial state of patients).

RESULTS: It has been established that the technology of combined use of ozone and transcranial magnetotherapy is most effective in the initial clinical manifestations of chronic generalized periodontitis and minimal values of other pathogenetically significant parameters (microcirculation, oxygen metabolism, lipid peroxidation disorders) in the initial state.

CONCLUSION: The clinical and laboratory cluster identified as a result of mathematical analysis — the index of bleeding of the gingival sulcus, the volume of nutritive blood flow, the fluorescent indicator of oxygen consumption, the quality of life according to the Daily Life domain generalized periodontitis, determining the indications and contraindications for the use of this treatment regimen for inflammatory periodontal diseases.

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About the authors

Olga I. Ryabtsun

LLC "Belta"

Author for correspondence.
Email: drnag@mail.ru
ORCID iD: 0000-0003-4208-8074
Russian Federation, Moscow

Sergey N. Nagornev

Center for Strategic Planning and Management of Biomedical Health Risks

Email: drnag@mail.ru
ORCID iD: 0000-0002-1190-1440
SPIN-code: 2099-3854

Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Valery K. Frolkov

Center for Strategic Planning and Management of Biomedical Health Risks

Email: drnag@mail.ru
ORCID iD: 0000-0002-1277-5183
SPIN-code: 3183-0883

Dr. Sci. (Biol.), Professor

Russian Federation, Moscow

Elena V. Gusakova

Central State Medical Academy of Department of Presidential Affairs

Email: drnag@mail.ru
ORCID iD: 0000-0003-3254-0354
SPIN-code: 5913-9674

Dr. Sci. (Med.)

Russian Federation, Moscow

References

  1. Bobrovnitskiy IP, Vasilenko AM. Principles of personalization and predictability in restorative medicine. Herald of Restorative Medicine. 2013;(1):2–6. (In Russ).
  2. Kulish VV, Frolkov VK, Nagornev SN. Predictors of the effectiveness of the use of transcranial magnetotherapy. Russian Journal of Rehabilitation Medicine. 2016;(4):59–63. (In Russ).
  3. Abdurakhmanova RZ, Nikonorova MV, Nagornev SN, Khudov VV. Predictors of the effectiveness of the use of transcranial magnetotherapy in combination with herbal medicine in the treatment of arterial hypertension. Russian Journal of Rehabilitation Medicine. 2018;(1):50–63. (In Russ).
  4. Mikhailenko LV, Bobrovnitskiy IP, Nagornev SN, Frolkov VK. Predictor significance of the initial morphological and functional indicators in assessing the effectiveness of rehabilitation correction of arterial hypertension. Questions of Balneology, Physiotherapy and Exercise Therapy. 2010;(2):35–38. (In Russ).
  5. Ponomarenko GN. The concept of translational medicine in physiotherapy and rehabilitation. Physiotherapy, Balneology and Rehabilitation. 2014;(3):4–12. (In Russ).
  6. Sharashova EE, Kholmatova KK, Gorbatova MA, Grzhibovsky AM. Application of multiple linear regression analysis in healthcare using the SPSS statistical software package. Science and Health. 2017;(3):5–31. (In Russ).
  7. Grinhalkh T. Basics of evidence-based medicine. Moscow; 2018. 336 p. (In Russ).
  8. Khaidarova NB. Analysis of modern methods of treatment of chronic generalized periodontitis. Actual Scientific Research in the Modern World. 2020;(7-4):55–59. (In Russ).
  9. Mikhailova IG, Moskovsky AV, Karpunina AV, et al. Comparative analysis of complex treatment of chronic generalized periodontitis. Russian Stomatology. 2020;13(4):12–15. (In Russ).
  10. Filippova LA, Gerasimenko OV. Application of ozone therapy in the complex treatment of chronic periodontitis. Chief Doctor of the South of Russia. 2017;(2-1):13–15. (In Russ).
  11. Sotieva ZK, Khetagurov SK. Study of the effectiveness of ozone therapy in inflammatory periodontal diseases. Health and Education in the XXI Century. 2016;(1):77–80. (In Russ).
  12. Nagornev SN, Frolkov VK, Kulish AV, Samsonova OS. Methodology of systemic application of transcranial magnetic effects in conditions of hemocirculatory and dysmetabolic disorders. Russian Journal of Rehabilitation Medicine. 2016;(2):32–44. (In Russ).
  13. Mikhailova IG, Moskovsky AV, Luzikova EM, et al. Assessment of index indicators of complex treatment of chronic generalized periodontitis. In: Collection of scientific works of young scientists and specialists. Cheboksary; 2020. Р. 278–282. (In Russ).
  14. Smirnyagina VV. The possibility of using the quality of life criterion to assess the effectiveness of treatment of moderate chronic generalized periodontitis [dissertation abstract]. Moscow; 2007. 24 p. (In Russ).
  15. Mokhova VA. The effect of complex treatment of generalized periodontitis on the quality of life of patients [dissertation abstract]. Voronezh; 2010. 24 p. (In Russ).
  16. Vazhenin AV, Karnaukh PA. Method for evaluating the effectiveness of prostate cancer treatment. Siberian Journal of Oncology. 2008;(3):21–24. (In Russ).
  17. Sanatoria.ru. Bobrovnitskiy IP, Nagornev SN, Ryabtsun OI, et al. Mechanisms of antioxidant activity of course use of ozone therapy in patients with chronic generalized periodontitis. In: Modern trends and prospects for the development of health resort business in the Russian Federation: Collection of abstracts of the forum "Zdravnitsa-2019". (In Russ). Available from: http://sanatoria.ru/text.php?id=1733
  18. Nagornev SN, Ryabtsun OI, Frolkov VK, Puzyreva GA. Analysis of the dynamics of the state of microcirculatory-tissue systems of periodontal disease in patients with chronic generalized periodontitis with the course of ozone therapy in combination with transcranial exposure to a low-frequency magnetic field. System Analysis and Control in Biomedical Systems. 2018;17(4):842–853. (In Russ).

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