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Information-predictive approach to evaluation of the efficiency of treatment of chronic generalized periodontitis using non-drug technologies ABSTRACT
- Authors: Ryabtsun O.I.1, Nagornev S.N.2, Frolkov V.K.2, Gusakova E.V.3
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Affiliations:
- LLC "Belta"
- Center for Strategic Planning and Management of Biomedical Health Risks
- Central State Medical Academy of Department of Presidential Affairs
- Issue: Vol 20, No 1 (2021)
- Pages: 53-60
- Section: Original studies
- URL: https://rjpbr.com/1681-3456/article/view/82999
- DOI: https://doi.org/10.17816/1681-3456-2021-20-1-53-60
- ID: 82999
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Abstract
BACKGROUND: The information-predictive approach can be used for determining biomarkers as predictors that allow predicting the effectiveness of the treatment of chronic generalized periodontitis using the combined use of ozone and transcranial magnetotherapy.
AIMS: Determination of the set of initial morphometric parameters that have predictive significance, as well as the development of a method for the integral assessment of the clinical effectiveness of the combined use of ozone and transcranial magnetotherapy in patients with chronic generalized periodontitis.
MATERIALS AND METHODS: A multiple regression model was built, which establishes the relationship between the dependent variable (effective sign — treatment effectiveness) and the value of independent variables (factors characterizing the initial state of patients).
RESULTS: It has been established that the technology of combined use of ozone and transcranial magnetotherapy is most effective in the initial clinical manifestations of chronic generalized periodontitis and minimal values of other pathogenetically significant parameters (microcirculation, oxygen metabolism, lipid peroxidation disorders) in the initial state.
CONCLUSION: The clinical and laboratory cluster identified as a result of mathematical analysis — the index of bleeding of the gingival sulcus, the volume of nutritive blood flow, the fluorescent indicator of oxygen consumption, the quality of life according to the Daily Life domain generalized periodontitis, determining the indications and contraindications for the use of this treatment regimen for inflammatory periodontal diseases.
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About the authors
Olga I. Ryabtsun
LLC "Belta"
Author for correspondence.
Email: drnag@mail.ru
ORCID iD: 0000-0003-4208-8074
Russian Federation, Moscow
Sergey N. Nagornev
Center for Strategic Planning and Management of Biomedical Health Risks
Email: drnag@mail.ru
ORCID iD: 0000-0002-1190-1440
SPIN-code: 2099-3854
Dr. Sci. (Med.), Professor
Russian Federation, MoscowValery K. Frolkov
Center for Strategic Planning and Management of Biomedical Health Risks
Email: drnag@mail.ru
ORCID iD: 0000-0002-1277-5183
SPIN-code: 3183-0883
Dr. Sci. (Biol.), Professor
Russian Federation, MoscowElena V. Gusakova
Central State Medical Academy of Department of Presidential Affairs
Email: drnag@mail.ru
ORCID iD: 0000-0003-3254-0354
SPIN-code: 5913-9674
Dr. Sci. (Med.)
Russian Federation, MoscowReferences
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