Physical Activity and the Myokine Irisin as a Non-Pharmacological Approach to Alzheimer’s Disease Treatment



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Abstract

Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive decline, memory impairment, synaptic dysfunction, and neurodegeneration. Currently available treatments are primarily aimed at temporarily alleviating symptoms without addressing the underlying pathogenic mechanisms. In recent years, increasing attention has been given to the development of non-pharmacological approaches capable of slowing AD progression and improving cognitive function. One such promising avenue is the investigation of irisin—a myokine secreted in response to physical exercise—which has been shown in recent studies to exert multifaceted neuroprotective effects. Irisin participates in the regulation of brain-derived neurotrophic factor (BDNF) expression, promotes neurogenesis, enhances insulin sensitivity and energy metabolism, and reduces neuroinflammation and oxidative stress. Preclinical studies demonstrate that irisin administration improves memory performance, spatial learning, and synaptic plasticity in animal models of AD. Moreover, physical activity—which naturally stimulates irisin secretion—has shown a positive impact on cognitive function and overall well-being in individuals with AD.  This review summarizes current findings on the mechanisms of irisin action and its role in the pathogenesis and potential treatment of AD. The need for further clinical studies is emphasized, particularly those aimed at exploring pharmacological modulation of irisin and integrating physical exercise into comprehensive treatment programs. Irisin is thus considered a promising target for the development of novel preventive and therapeutic strategies for Alzheimer’s disease.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80650 от 15.03.2021 г.