HEMODYNAMIC EFFECTS OF SMOKING ELECTRONIC AND TRADITIONAL CIGARETTES: META-ANALYSIS



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Electronic cigarettes (ECs) are currently widely used as an alternative to traditional smoking, particularly among young people and those attempting to quit. However, their impact on the cardiovascular system remains incompletely understood and is a subject of ongoing debate within the scientific community. This meta-analysis aimed to evaluate the acute effects of ECs with and without nicotine on key hemodynamic parameters, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR), compared to the effects of conventional cigarettes. Twenty-two studies published over the past 10 years (2014-2024) were included in the meta-analysis, comprising a total of 590 participants. The results demonstrated that the use of ECs with nicotine induces a statistically significant increase in SBP, DBP, and HR. Conventional cigarettes exert similar effects on these parameters, but the magnitude of these changes is greater than that observed with ECs with nicotine, likely due to the additional effects of other toxic components in tobacco smoke. Importantly, ECs without nicotine did not demonstrate a statistically significant effect on the analyzed hemodynamic parameters. Our findings highlight the importance of considering the potential cardiovascular risks associated with EC use, particularly those containing nicotine. Further research is needed to assess the long-term effects of electronic cigarette use on the cardiovascular system

Full Text

Restricted Access

About the authors

I. Yu. Pastarnakov

Смоленский государственный медицинский университет

Author for correspondence.
Email: igorpastarnakov19@mail.ru
ORCID iD: 0009-0000-2706-7668
Russian Federation

O. A. Kozyrev

Smolensk State Medical University

Email: oak2@yandex.ru
ORCID iD: 0000-0001-9715-5532
SPIN-code: 6038-5182

MD, Professor

Russian Federation, Smolensk

References

  1. Dimitriadis, K.; Narkiewicz, K.; Leontsinis, I.; Konstantinidis, D.; Mihas, C.; Andrikou, I.; Thomopoulos, C.; Tousoulis, D.; Tsioufis, K. Acute Effects of Electronic and Tobacco Cigarette Smoking on Sympathetic Nerve Activity and Blood Pressure in Humans. Int J Environ Res Public Health 2022, 19 (6), 3237
  2. Antoniewicz, L.; Brynedal, A.; Hedman, L.; Lundbäck, M.; Bosson, J. A. Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways. Cardiovascular Toxicology 2019, 19 (5), 441.
  3. Gonzalez, J. E.; Cooke, W. H. Acute Effects of Electronic Cigarettes on Arterial Pressure and Peripheral Sympathetic Activity in Young Nonsmokers. Am J Physiol Heart Circ Physiol 2021, 320 (1), H248–H255.
  4. Biondi-Zoccai, G.; Sciarretta, S.; Bullen, C.; Nocella, C.; Violi, F.; Loffredo, L.; Pignatelli, P.; Perri, L.; Peruzzi, M.; Marullo, A. G. M.; De Falco, E.; Chimenti, I.; Cammisotto, V.; Valenti, V.; Coluzzi, F.; Cavarretta, E.; Carrizzo, A.; Prati, F.; Carnevale, R.; Frati, G. Acute Effects of Heat-Not-Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking ( SUR - VAPES ) 2 Randomized Trial. J Am Heart Assoc 2019, 8 (6), e010455.
  5. Skotsimara, G.; Antonopoulos, A. S.; Oikonomou, E.; Siasos, G.; Ioakeimidis, N.; Tsalamandris, S.; Charalambous, G.; Galiatsatos, N.; Vlachopoulos, C.; Tousoulis, D. Cardiovascular Effects of Electronic Cigarettes: A Systematic Review and Meta-Analysis. European Journal of Preventive Cardiology 2019, 26 (11), 1219–1228.
  6. Rezk-Hanna, M.; Gupta, R.; Nettle, C. O.; Dobrin, D.; Cheng, C.-W.; Means, A.; Brecht, M.-L.; Tashkin, D. P.; Araujo, J. A. Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness. Chest 2022, 161 (1), 208–218.
  7. Franzen, K. F.; Willig, J.; Cayo Talavera, S.; Meusel, M.; Sayk, F.; Reppel, M.; Dalhoff, K.; Mortensen, K.; Droemann, D. E-Cigarettes and Cigarettes Worsen Peripheral and Central Hemodynamics as Well as Arterial Stiffness: A Randomized, Double-Blinded Pilot Study. Vasc Med 2018, 23 (5), 419–425.
  8. Chaumont, M.; Tagliatti, V.; Channan, E. M.; Colet, J.-M.; Bernard, A.; Morra, S.; Deprez, G.; Van Muylem, A.; Debbas, N.; Schaefer, T.; Faoro, V.; van de Borne, P. Short Halt in Vaping Modifies Cardiorespiratory Parameters and Urine Metabolome: A Randomized Trial. Am J Physiol Lung Cell Mol Physiol 2020, 318 (2), L331–L344.
  9. D’Ruiz CD, O’Connell G, Graff DWet al. Measurement of cardiovascular and pulmonary function endpoints and other physiological effects following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers. Regul Toxicol Pharmacol 2017; 87: 36–53.
  10. Farsalinos KE, Tsiapras D, Kyrzopoulos Set al. Acute effects of using an electronic nicotine-delivery device (electronic cigarette) on myocardial function: Comparison with the effects of regular cigarettes. BMC Cardiovasc Disord 2014; 14: 78–78.
  11. Farsalinos K, Cibella F, Caponnetto Pet al. Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes. Intern Emerg Med 2016; 11: 85–94.
  12. Moheimani RS, Bhetraratana M, Peters KMet al. Sympathomimetic effects of acute e-cigarette use: Role of nicotine and non-nicotine constituents. J Am Heart Assoc 2017; 6: e006579–e006579.
  13. Nides MA, Leischow SJ, Bhatter Met al. Nicotine blood levels and short-term smoking reduction with an electronic nicotine delivery system. Am J Health Behav 2014; 38: 265–274.
  14. Oncken CA, Litt MD, McLaughlin LDet al. Nicotine concentrations with electronic cigarette use: Effects of sex and flavor. Nicotine Tob Res 2015; 17: 473–478.
  15. Polosa R, Morjaria JB, Caponnetto Pet al. Blood pressure control in smokers with arterial hypertension who switched to electronic cigarettes. Int J Environ Res Public Health 2016; 13: E1123–E1123.
  16. Spindle TR, Hiler MM, Breland ABet al. The influence of a mouthpiece-based topography measurement device on electronic cigarette user’s plasma nicotine concentration, heart rate, and subjective effects under directed and ad libitum use conditions. Nicotine Tob Res 2017; 19: 469–476.
  17. Szoltysek-Boldys I, Sobczak A, Zielinska-Danch Wet al. Influence of inhaled nicotine source on arterial stiffness. Przegl Lek 2014; 71: 572–575.
  18. Vansickel AR, Weaver MF, Eissenberg T. Clinical laboratory assessment of the abuse liability of an electronic cigarette. Addiction 2012; 107: 1493–1500.
  19. Vansickel AR, Eissenberg T. Electronic cigarettes: Effective nicotine delivery after acute administration. Nicotine Tob Res 2013; 15: 267–270.
  20. Vansickel AR, Cobb CO, Weaver MFet al. A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: Nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prev 2010; 19: 1945–1953.
  21. Vlachopoulos C, Ioakeimidis N, Abdelrasoul Met al. Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers. J Am Coll Cardiol 2016; 67: 2802–2803.
  22. Yan XS, D’Ruiz C. Effects of using electronic cigarettes on nicotine delivery and cardiovascular function in comparison with regular cigarettes. Regul Toxicol Pharmacol 2015; 71: 24–34.
  23. Lyytinen, G.; Melnikov, G.; Brynedal, A.; Anesäter, E.; Antoniewicz, L.; Blomberg, A.; Wallén, H.; Bosson, J. A.; Hedman, L.; Tehrani, S.; Lundbäck, M. Use of Heated Tobacco Products (IQOS) Causes an Acute Increase in Arterial Stiffness and Platelet Thrombus Formation. Atherosclerosis 2024, 390, 117335.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86508 от 11.12.2023. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80650 от 15.03.2021 г.