Clinical efficacy of electrophoresis of hydrobiont collagenase isoenzymes at the rehabilitation stage in women with vulvar lichen sclerosus

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BACKGROUND: Due to insufficient effectiveness of currently known methods of treatment of patients with scleroatrophic lichenes of the vulva, as well as the lack of reasonable ways to manage patients at the stage of rehabilitation, there is a need to search for new approaches to solve this problem.

AIMS: to study the possibility to apply electrophoresis of the enzyme preparation from hydrobiont collagenases at the stage of rehabilitation of women with scleroatrophic lichenes of the vulva.

MATERIAL AND METHODS: In a group of 86 female patients with scleroatrophic lichenes of the vulva (mean age 49±13 years) a comparative assessment of the efficacy of traditional approach to scleroatrophic lichenes of the vulva treatment and staged treatment using electrophoresis of the enzyme preparation at the stage of rehabilitation was carried out.

RESULTS: The developed approach to the treatment of patients with scleroatrophic lichenes of the vulva with application of electrophoresis of the enzyme complex after stabilization of the cutaneous process by glucocorticosteroids at the rehabilitation stage effectively reduces severity and activity of cutaneous manifestations of scleroatrophic lichenes of the vulva that was reflected in the index (LS-A) from 22, the index (LS-A) from 22.70±4.71 to 7.45±1.90 and the dermatological quality of life index (DIQL) from 22.77±4.86 to 4.95±1.10, in comparison with the patients in the control group, where the conventional therapy was conducted, where the LS-A index showed dynamics from 19.67±4.34 to 12.69±3.35, and the DIQL significant differences between the groups by 16 weeks of follow-up (p <0.001).

CONCLUSION: During staged treatment, a more pronounced and long-lasting effect is observed in the group of patients with electrophoresis of the enzyme complex during the rehabilitation stage as compared to the group with emollients.

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About the authors

Andrei V. Ignatovskiy

Academician I.P. Pavlov First St. Petersburg State Medical University; Dermatology and Reproductive Health Clinic of Dr. Ignatovsky

Author for correspondence.
ORCID iD: 0000-0003-3048-2488
SPIN-code: 8500-0451

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs

ORCID iD: 0000-0002-5044-5265
SPIN-code: 1107-4372

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Dynamics of the index LS-S assessing the area of skin lesions in scleroatrophic lichen.

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2. Fig. 2. The dynamics of the index LS-А assessing the activity of the skin process in scleroatrophic lichen.

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3. Fig. 3. Dynamics of dermatological index of patients' quality of life.

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