The effectiveness of using mesodiencephalic modulation in combination with ozone therapy in patients with peri-implantitis according to long-term results of the study

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Abstract

BACKGROUND: Evaluation of the clinical effectiveness of the use of various treatment regimens for peri-implantitis should take into account not only the immediate results achieved during treatment, but also the manifestations of the disease in the long-term period.

AIM: Assessment of the effectiveness of the integrated use of mesodiencephalic modulation (MDM therapy) and ozone therapy in patients with dental peri-implantitis based on long-term results of the study.

MATERIALS AND METHODS: The study was carried out with the participation of 116 patients with peri-implantitis of classes I and II according to S.A. Jovanovic. Using the fixed randomization method, all patients were divided into 4 groups based on the results of generating random numbers obtained using a computer program. Patients of the first group (control group, n=28) received standard dental therapy, including professional oral hygiene and local use of antiseptics. Patients of the second group (comparison group 1; n=29) received a course of ozone therapy in addition to standard dental therapy, for which the periimplant area was irrigated with ozonated saline solution with an ozone concentration of 2.5–5.5 μg/ml for 15 minutes. Patients of the third group (comparison group 2; n=30) received a course of MDM therapy in addition to standard dental therapy. In the fourth group (main group; n=29), patients, along with standard dental therapy, received a course of complex physiotherapy in the form of a combination of ozone and MDM therapy. Long-term results of complex therapy for peri-implantitis were assessed 6 and 12 months after the end of treatment.

RESULTS: A comparative assessment of dental indices in the long-term period showed that the addition of SST with a course of physiotherapeutic effects, in general, is accompanied by the preservation of the effect achieved after the end of treatment. At the same time, the best results were noted in the main group with the combined use of ozone and MDM therapy. Changes in the osseointegration index also indicated the preservation of the values achieved after the end of therapy, and in the main group a significant increase in this parameter was observed, which indicated additional activation of osseointegration processes under the influence of the physiotherapeutic complex.

CONCLUSION: The results of the performed follow-up study convincingly prove the advantages of the additional use of therapeutic physical factors (MDM therapy, ozone therapy and their combination).

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About the authors

Madina R. Balayeva

North-Ossetian State Medical Academy

Email: mbmbmb1995@mail.ru
ORCID iD: 0009-0003-9507-8459

MD

Russian Federation, Vladikavkaz

Anna A. Remizova

North-Ossetian State Medical Academy

Email: annasas@mail.ru
ORCID iD: 0000-0001-5951-9454
SPIN-code: 3504-9885

MD, Dr. Sci. (Med.), Associate Professor

Russian Federation, Vladikavkaz

Sergey N. Nagornev

Central State Medical Academy of Department of Presidential Affairs

Author for correspondence.
Email: drnag@mail.ru
ORCID iD: 0000-0002-1190-1440
SPIN-code: 2099-3854

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Mikhail A. Elfimov

Central State Medical Academy of Department of Presidential Affairs

Email: drnag@mail.ru
ORCID iD: 0000-0001-6153-9673

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

Valery Е. Illarionov

Petrovsky National Research Centre of Surgery

Email: drnag@mail.ru
ORCID iD: 0000-0001-6416-7836
SPIN-code: 9712-3466

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

References

  1. Zekiy AO. Optimization of osseointegration control in the treatment and prevention of complications in patients with fixed structures supported by dental implants [dissertation abstract]: 14.01.14. Place of defence: I.M. Sechenov First Moscow State Medical University. Moscow; 2018. 48 p. (In Russ).
  2. Akopyan GV, Harutyunyan AE, Hovakimyan AZ, et al. The use of dental implantation and aesthetic medicine methods to restore facial aesthetics in patients with complete edentia. Meditsina, nauka i obrazovanie. 2022;(33):77–85. EDN: UNAXRU doi: 10.56936/18291775-2022.33-77
  3. Parvini P, Trimpou G, Begic A, et al. Esthetic and clinical outcomes after immediate placement and restoration: Comparison of two implant systems in the anterior maxilla: A cross-sectional study. Clin Implant Dent Relat Res. 2023;25(2):252–260. EDN: OVYGIR doi: 10.1111/cid.13158
  4. Greenstein G, Eskow R. High prevalence rates of peri-implant mucositis and peri-implantitis post dental implantations dictate need for continuous peri-implant maintenance. Compend Contin Educ Dent. 2022;43(4):206–213.
  5. Hashim D, Cionca N, Combescure C, et al. The diagnosis of periimplantitis: A systematic review on the predictive value of bleeding on probing. Clin Oral Implants Res. 2018;29(Suppl 16):276–293. doi: 10.1111/clr.13127
  6. Lindhe J, Meyle J. Peri-implant diseases: Consensus report of the sixth European workshop on periodontology. J Clin Periodontol. 2008;35(8, Suppl):282–285. doi: 10.1111/j.1600-051X.2008.01283.x
  7. Livshits VI, Nagornev SN, Frolkov VK, Gvetadze RS. Dynamics of the clinical state of patients with peri-implantitis under conditions of complex application of physiotherapy technologies. Physiotherapist. 2021;(4):42–52. EDN: JCKZEP doi: 10.33920/med-14-2108-05
  8. Razina IN, Lomiashvili LM, Nedoseko VB. Non-surgical treatments of complications after dental implantation. perspectives for infrared laser light in the treatment of mucositis and peri-implantitis. Laser Med. 2020;24(1):49–56. EDN: PFSSZF doi: 10.37895/2071-8004-2020-24-1-49-56
  9. Santonocito S, Polizzi A, Cavalcanti R, et al. Impact of laser therapy on periodontal and peri-implant diseases. Photobiomodul Photomed Laser Surg. 2022;40(7):454–462.
  10. Yumashev AV. Mesodiencephalic modulation in the complex of treatment and prevention of inflammatory complications in patients with orthopedic structures during dental implantation [dissertation abstract]: 14.01.14. Place of defence: I.M. Sechenov First Moscow State Medical University. Moscow; 2019. 48 p. (In Russ).
  11. Mikhalchenko DV, Salyamov KY, Makedonova YA, et al. Application of ozone therapy in the treatment of dental implantation complications. Bulletin Volgograd State Med Univer. 2020;(2):77–80. EDN: SHBKXF doi: 10.19163/1994-9480-2020-2(74)-77-80
  12. Balaeva MR. Preventive activity of a course of complex application of mesodiencephalic modulation and ozone therapy during dental implantation. In: World of Science: Collection of articles of the V International Scientific and Practical Conference. Penza: Science and Enlightenment; 2023. P. 125–128. EDN: GRJWXZ
  13. Balaeva MR, Remizova AA, Nagornev SN. The influence of therapeutic physical factors on the dynamics of the clinical condition and quality of life of patients with peri-implantitis. Russ J Physical Ther Balneother Rehabilitat. 2022;22(3):33–41. EDN: JEBKEG doi: 10.17816/624676
  14. Radchuk VB, Hasiuk NV, Bozhyk SS, et al. Initiating factors of complications development during prosthetics of teeth with fixed prostheses. Wiad Lek. 2021;74(5):1164–1168.
  15. Jovanovic SA. Diagnosis and treatment of peri-implant disease. Curr Opin Periodontol. 1994. P. 194–204.
  16. Minenkov AA, Filimonov RM, Pokrovsky VI, et al. Basic principles and tactics of ozone therapy: A manual for doctors. Moscow: RNTs VM i K; 2001. 37 p. (In Russ).
  17. Muhelmann HR, Son S. Gingival sulcus bleeding: A leading symptom in initial gingivitis. Helv Odontol Acta. 1971;15(2):107–113.
  18. Green JC, Vermillion JR. Oral hygiene index A method for classifying oral hygiene status. J Am Dent Assoc. 1960;61:172–179. doi: 10.14219/jada.archive.1960.0177
  19. Parma C. Parodontopathien. Leipzig: J.A. Barth; 1960. 203 р.
  20. Porfenchuk DA. Diagnostic and prognostic value of determining the stability of dental implants during early functional load [dissertation]: 14.01.14. Place of protection: National Medical Research Centre ‘Central Research Institute of Stomatology and Maxillofacial Surgery’ of the Ministry of Health of Russia. Moscow; 2020. 164 p. (In Russ).
  21. Zoirov TE, Javadova LM. Modern views on the methods of treatment of chronic generalized periodontitis (literature review). Vestnik nauki i obrazovaniya. 2020;(20-1):62–65. EDN: JLUGSD
  22. Krupatkin AI, Sidorov VV. Functional diagnostics of the state of microcirculatory tissue systems: Oscillations, information, nonlinearity (Guide for doctors). Moscow; 2016. 496 p. (In Russ).
  23. Gorban AN, Smirnova EV. The effect of group stress and correlation adaptometry [Internet resource]. 2018. Available from: http://adaptometry.narod.ru/Index.htm. Accessed: 10.02.2024.
  24. Gorban AN, Tyukina TA, Smirnova EV, et al. Evolution of adaptation mechanisms: Adaptation energy, stress, and oscillating death. J Theoretical Biology. 2016;405:127–139. EDN: YUUGMH doi: 10.1016/j.jtbi.2015.12.017
  25. Shpitonkov MI. Correlation adaptometry. Heart surgery effectiveness evaluating. Operations Research (models, systems, solutions). 2020;(6):46–50. EDN: STXASJ doi: 10.14357/ORMSS20200106
  26. Burmistrova AL, Bakhareva LI, Belyaeva SV, et al. Metaorganism. Stress and adaptation. Monograph. Ed. by A.L. Burmistrova. Chelyabinsk: Chelyabinsk State University Publishing House; 2019. 239 p. (In Russ).
  27. Starodubov VI, Khalfin RA, Vorobyov PA, et al. Protocol for the management of patients “Partial absence of teeth (partial secondary adentia)”. Moscow; 2004. 56 p. (In Russ).
  28. Viebahn-Haensler R, León Fernández OS. Ozone in medicine. The low-dose ozone concept and its basic biochemical mechanisms of action in chronic inflammatory diseases. Int J Mol Sci. 2021;22(15):7890. doi: 10.3390/ijms22157890
  29. Konev SM, Tsvetkova AV, Koneva ES, et al. The effect of ozone therapy on microhemodynamics and peripheral blood flow in patients with covid-associated pneumonia in the early recovery period. Physical Rehabilitat Med. 2023;5(2):52–64. EDN: MADVHA doi: 10.26211/2658-4522-2023-5-2-52-64
  30. Di Mauro R, Cantarella G, Bernardini R, et al. The biochemical and pharmacological properties of ozone: The smell of protection in acute and chronic diseases. Int J Mol Sci. 2019;20(3):634. doi: 10.3390/ijms20030634
  31. Huth KC, Saugel B, Jakob FM, et al. Effect of aqueous ozone on the NF-kappa B system. J Dent Res. 2007;86(5):451–456. doi: 10.1177/154405910708600512
  32. Re L, Martínez-Sánchez G, Bordicchia M, et al. Is ozone preconditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result. Eur J Pharmacol. 2014;742:158–162. doi: 10.1016/j.ejphar.2014.08.029
  33. Razumov AN. Sanatorium-resort treatment: National guide. Ed. by A.N. Razumov, V.I. Starodubov, G.N. Ponomarenko. (Series: National Guidelines). Moscow: GEOTAR-Media; 2021. 752 p. (In Russ). doi: 10.33029/9704-6022-1-SKL-2021-1-752
  34. Ponomarenko GN. Current issues in physiotherapy: Selected lectures. Saint Petersburg: S.M. Kirov Military Medical Academy; 2010. 238 p.
  35. Anzolin AP, da Silveira-Kaross NL, Bertol CD. Ozonated oil in wound healing: What has already been proven? Med Gas Res. 2020;10(1):54–59. doi: 10.4103/2045-9912.279985
  36. He S, Chen W, Xia J, et al. Effects of ozone autohemotherapy on blood VEGF, TGF-β and PDGF levels after finger replantation. Ann Palliat Med. 2020;9(5):3332–3339. doi: 10.21037/apm-20-1467
  37. Franzini M, Valdenassi L, Ricevuti G, et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int Immunopharmacol. 2020;88:106879. doi: 10.1016/j.intimp.2020.106879
  38. Kulchitskaya DB, Kolbakhova SN. Non-drug methods of treatment of patients with arterial hypertension. Bulletin Restorat Med. 2020;(3):65–68. EDN: XJOMFY doi: 10.38025/2078-1962-2020-97-3-65-68
  39. Badtieva VA. Physical factors in the treatment of patients with arterial hypertension with associated coronary heart disease [dissertation abstract]: 14.00.51, 14.00.06. Place of protection: Russian Scientific Center for Medical Rehabilitation and Balneology. Moscow; 2002. 46 p. (In Russ).
  40. Badtieva VA. Laser therapy for patients with hypertension and coronary insufficiency [dissertation abstract]: 14.00.34. Moscow; 1995. 20 p. (In Russ). EDN: ZKINTJ
  41. Physical and rehabilitation medicine: National guidelines. Ed. by G.N. Ponomarenko. 2nd revised and updated. Moscow: GEOTAR-Media; 2023. 912 p. (In Russ).
  42. Epifanov AV, Epifanov VA, Galsanova ES, et al. Medical rehabilitation: Textbook. Moscow: GEOTAR-Media; 2022. 664 p. (In Russ). EDN: QGFBAN doi: 10.33029/9704-6688-9-MRE-2022-1-664
  43. Nagornev SN, Kulish AV, et al. Methodology of system use of transscranial magnetic exposures under conditions of hemocyricular and dismitabolic disturbances. Russ J Rehab Med. 2016;(2):32–44. EDN: ZSGLQX
  44. Benkov AA, Nagornev SN, Frolkov VK, et al. Informativity of the method of correlation adaptometry for assessing the severity of the corrective effect of combined use therapeutic physical factors on the example of metabolic syndrome. Russ J Physical Ther Balneother Rehabilitat. 2023;22(1):5–14. EDN: JPHBQI doi: 10.17816/rjpbr401115

Supplementary files

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2. Fig. 1. Dynamics of the mean absolute correlation in the remote period in patients with peri-implantitis under different therapy regimens.

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