Photodynamic therapy for correction of involutive facial skin changes

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Abstract

Background. The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy.

Objective: the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure.

Methods. The study involved patients aged 40−60 years with signs of involutive changes in the skin of the face. In group 1 (n = 36), patients underwent therapy using only light coherent radiation. In group 2 (n = 35), patients underwent PDT using light coherent radiation.

Results. According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group 2, more positive indicators were obtained than in group 1. When assessing safety, the results in groups 1 and 2 are comparable.

Conclusions. The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.

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About the authors

S. I. Surkichin

Central State Medical Academy of the Administrative Department of the President of Russia

Email: info@eco-vector.com
ORCID iD: 0000-0003-0521-0333

PhD

Russian Federation

N. V. Bochkova

Central State Medical Academy of the Administrative Department of the President of Russia

Email: info@eco-vector.com
ORCID iD: 0000-0001-6457-7130
Russian Federation

L. S. Kholupova

Central State Medical Academy of the Administrative Department of the President of Russia

Author for correspondence.
Email: karsekals@gmail.com
ORCID iD: 0000-0002-2781-4587
Russian Federation

References

  1. Kim M, Park HJ. Molecular mechanisms of skin aging and rejuvenation. Licensee IntechOpen; 2016. doi: 10.5772/62983.
  2. Alenichev AYu, Kruglova LS, Fedorov SM, et al. Combined application of microneedle RF-therapy and injections by platelet-rich plasma activated by autological thrombin in aesthetic medicine. Russian Journal of the Physial Therapy, Balneotherapy and Rehabilitation. 2017;16(6):320-324. (In Russ). doi: 10.18821/1681-3456-2017-16-5-320-324.
  3. Rivard J, Ozog D. Henry Ford Hospital dermatology experience with Levulan Kerastick and blue light photodynamic therapy. J Drugs Dermatol. 2006;5(6):556-561.
  4. Babilas P, Schreml S, Landthaler M, et al. Photodynamic therapy in dermatology: state-of-the-art. Photodermatol Photoimmunol Photomed. 2010;26(3):118–132. doi: 10.1111/j.1600-0781.2010.00507.x.
  5. Peng Q, Soler AM, Warloe T, et al. Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J Photochem Photobiol B. 2001;62(3):140-145. doi: 10.1016/s1011-1344(01)00173-7.
  6. Patent RUS N 2523380 C1. Ponomaryov GV, Kojfman OI, Shestakov VN. Fotosensibilizator i sposob ego polucheniya. (In Russ). Avai­lable from: https://yandex.ru/patents/doc/RU2523380C1_20140720.

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