Potential Druggability of Mesenchymal Stem/Stromal Cell-derived Exosomes


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Abstract

:Exosomes secreted by mesenchymal stem/stromal cells (MSC-Exos) are advantageous candidate sources for novel acellular therapy. Despite the current standards of good manufacturing practice (GMP), the deficiency of suitable quality-control methods and the difficulties in large-scale preparation largely restrict the development of therapeutic products and their clinical applications worldwide. Herein, we mainly focus on three dominating issues commonly encountered in exosomal GMP, including issues upstream of the cell culture process, downstream of the purification process, exosomes quality control, and the drug properties of exosomes and their druggability from a corporate perspective. Collectively, in this review article, we put forward the issues of preparing clinical exosome drugs for the treatment of diverse diseases and provide new references for the clinical application of GMP-grade MSC-Exos.

About the authors

Fan Zhang

Faculty of Life Sciences and Medicine, Kunming University of Science and Technology

Email: info@benthamscience.net

Leisheng Zhang

Science and Technology Innovation Center, The Fourth People’s Hospital of Jinan (The Third Affiliated Hospital of Shandong First Medical University)

Email: info@benthamscience.net

Hao Yu

The Postdoctoral Research Station, School of Medicine, Nankai University

Author for correspondence.
Email: info@benthamscience.net

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