Treatment with Exosomes Derived from Mesenchymal Stem Cells: A New Window of Healing Science in Regenerative Medicine


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Abstract

Many studies have been conducted on the potential applications of mesenchymal stem cells (MSCs) over recent years due to their growing importance in regenerative medicine. Exosomes are considered cargos capable of transporting proteins, peptides, lipids, mRNAs, and growth factors. MSCsderived exosomes are also involved in the prevention or treatment of a variety of diseases, including cardiovascular diseases, neurological diseases, skin disorders, lung diseases, osteoarthritis, damaged tissue repair, and other diseases. This review attempted to summarize the importance of employing MSCs in regenerative medicine by gathering and evaluating information from current literature. The role of MSCs and the potential applications of MSCs-derived exosomes have also been discussed.

About the authors

Arezoo Hormozi

Student Research Committee, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Sajedeh Hasanzadeh

Student Research Committee, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Faezeh Ebrahimi

Student Research Committee, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Narges Daei

Student Research Committee, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Zahra Hajimortezayi

Student Research Committee, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Amir Mehdizadeh

Hematology and Oncology Research Center, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Majid Zamani

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University

Author for correspondence.
Email: info@benthamscience.net

References

  1. Rani S, Ryan AE, Griffin MD, Ritter T. Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications. Mol Ther 2015; 23(5): 812-23. doi: 10.1038/mt.2015.44 PMID: 25868399
  2. Harrell CR, Jovicic N, Djonov V, Volarevic V. Therapeutic use of mesenchymal stem cell-derived exosomes: From basic science to clinics. Pharmaceutics 2020; 12(5): 474. doi: 10.3390/pharmaceutics12050474 PMID: 32456070
  3. Keshtkar S, Azarpira N, Ghahremani MH. Mesenchymal stem cell-derived extracellular vesicles: Novel frontiers in regenerative medicine. Stem Cell Res Ther 2018; 9(1): 63. doi: 10.1186/s13287-018-0791-7 PMID: 29523213
  4. Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine 2020; 15: 6917-34. doi: 10.2147/IJN.S264498 PMID: 33061359
  5. Hong P, Yang H, Wu Y, Li K, Tang Z. The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: A comprehensive review. Stem Cell Res Ther 2019; 10(1): 242. doi: 10.1186/s13287-019-1358-y PMID: 31391108
  6. Hassanzadeh A, Rahman HS, Markov A, et al. Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities. Stem Cell Res Ther 2021; 12(1): 297. doi: 10.1186/s13287-021-02378-7 PMID: 34020704
  7. He C, Zheng S, Luo Y, Wang B. Exosome theranostics: Biology and translational medicine. Theranostics 2018; 8(1): 237-55. doi: 10.7150/thno.21945 PMID: 29290805
  8. An Y, Lin S, Tan X, et al. Exosomes from adipose‐derived stem cells and application to skin wound healing. Cell Prolif 2021; 54(3): e12993. doi: 10.1111/cpr.12993 PMID: 33458899
  9. Kalluri R. The biology and function of exosomes in cancer. J Clin Invest 2016; 126(4): 1208-15. doi: 10.1172/JCI81135 PMID: 27035812
  10. Hamzah RN, Alghazali KM, Biris AS, Griffin RJ. Exosome traceability and cell source dependence on composition and cell-cell cross talk. Int J Mol Sci 2021; 22(10): 5346. doi: 10.3390/ijms22105346 PMID: 34069542
  11. Mendt M, Rezvani K, Shpall E. Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant 2019; 54(S2): 789-92. doi: 10.1038/s41409-019-0616-z PMID: 31431712
  12. Yaghoubi Y, Movassaghpour A, Zamani M, Talebi M, Mehdizadeh A, Yousefi M. Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment. Life Sci 2019; 233: 116733. doi: 10.1016/j.lfs.2019.116733 PMID: 31394127
  13. Mianehsaz E, Mirzaei HR, Mahjoubin-Tehran M, et al. Mesenchymal stem cell-derived exosomes: A new therapeutic approach to osteoarthritis? Stem Cell Res Ther 2019; 10(1): 340. doi: 10.1186/s13287-019-1445-0 PMID: 31753036
  14. Doyle L, Wang M. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells 2019; 8(7): 727. doi: 10.3390/cells8070727 PMID: 31311206
  15. Lin J, Li J, Huang B, et al. Exosomes: Novel biomarkers for clinical diagnosis. ScientificWorldJournal 2015; 2015: 1-8. doi: 10.1155/2015/657086 PMID: 25695100
  16. Joo HS, Suh JH, Lee HJ, Bang ES, Lee JM. Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent. Int J Mol Sci 2020; 21(3): 727. doi: 10.3390/ijms21030727 PMID: 31979113
  17. Gorabi AM, Kiaie N, Barreto GE, Read MI, Tafti HA, Sahebkar A. The therapeutic potential of mesenchymal stem cell-derived exosomes in treatment of neurodegenerative diseases. Mol Neurobiol 2019; 56(12): 8157-67. doi: 10.1007/s12035-019-01663-0 PMID: 31197655
  18. Jia Y, Chen Y, Wang Q, et al. Exosome: Emerging biomarker in breast cancer. Oncotarget 2017; 8(25): 41717-33. doi: 10.18632/oncotarget.16684 PMID: 28402944
  19. Zamani M, Yaghoubi Y, Naimi A, et al. Humanized culture medium for clinical-grade generation of erythroid cells from umbilical cord blood CD34+ cells. Adv Pharm Bull 2021; 11(2): 335-42. PMID: 33880356
  20. Beeraka NM, Doreswamy SH, Sadhu SP, et al. The role of exosomes in stemness and neurodegenerative diseases-chemoresistant-cancer therapeutics and phytochemicals. Int J Mol Sci 2020; 21(18): 6818. doi: 10.3390/ijms21186818 PMID: 32957534
  21. Nikfarjam S, Rezaie J, Zolbanin NM, Jafari R. Mesenchymal stem cell derived-exosomes: A modern approach in translational medicine. J Transl Med 2020; 18(1): 449. doi: 10.1186/s12967-020-02622-3 PMID: 33246476
  22. Forsberg MH, Kink JA, Hematti P, Capitini CM. Mesenchymal stromal cells and exosomes: Progress and challenges. Front Cell Dev Biol 2020; 8: 665. doi: 10.3389/fcell.2020.00665 PMID: 32766255
  23. Casado-Díaz A, Quesada-Gómez JM, Dorado G. Extracellular vesicles derived from Mesenchymal Stem Cells (MSC) in regenerative medicine: Applications in skin wound healing. Front Bioeng Biotechnol 2020; 8: 146. doi: 10.3389/fbioe.2020.00146 PMID: 32195233
  24. Yaghoubi Y, Zamani M, Naimi A, et al. Human CD34+ hematopoietic stem cells culture in humanized culture medium for cell therapy. Gene Rep 2020; 20: 100718. doi: 10.1016/j.genrep.2020.100718
  25. Yaghoubi Y, Hassanzadeh A, Naimi A, et al. The effect of platelet lysate on expansion and differentiation megakaryocyte progenitor cells from cord blood CD34+ enriched cells. Iran J Ped Hematol Oncol 2021; 11(3): 172-82. doi: 10.18502/ijpho.v11i3.6563
  26. Tsiapalis D, O’Driscoll L. Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications. Cells 2020; 9(4): 991. doi: 10.3390/cells9040991 PMID: 32316248
  27. Harrell CR, Jovicic N, Djonov V, Arsenijevic N, Volarevic V. Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases. Cells 2019; 8(12): 1605. doi: 10.3390/cells8121605 PMID: 31835680
  28. Golchin A. Cell-based therapy for severe COVID-19 patients: Clinical trials and cost-utility. Stem Cell Rev Rep 2021; 17(1): 56-62. doi: 10.1007/s12015-020-10046-1 PMID: 33009982
  29. Cheng L, Zhang K, Wu S, Cui M, Xu T. Focus on mesenchymal stem cell-derived exosomes: Opportunities and challenges in cell-free therapy. Stem Cells Int 2017; 2017: 1-10. doi: 10.1155/2017/6305295 PMID: 29410682
  30. Sidhom K, Obi PO, Saleem A. A review of exosomal isolation methods: Is size exclusion chromatography the best option? Int J Mol Sci 2020; 21(18): 6466. doi: 10.3390/ijms21186466 PMID: 32899828
  31. Kurian TK, Banik S, Gopal D, Chakrabarti S, Mazumder N. Elucidating methods for isolation and quantification of exosomes: A review. Mol Biotechnol 2021; 63(4): 249-66. doi: 10.1007/s12033-021-00300-3 PMID: 33492613
  32. Bahr MM, Amer MS, Abo-El-Sooud K, Abdallah AN, El-Tookhy OS. Preservation techniques of stem cells extracellular vesicles: A gate for manufacturing of clinical grade therapeutic extracellular vesicles and long-term clinical trials. Int J Vet Sci Med 2020; 8(1): 1-8. doi: 10.1080/23144599.2019.1704992 PMID: 32083116
  33. Wu Y, Deng W, Klinke DJ II. Exosomes: Improved methods to characterize their morphology, RNA content, and surface protein biomarkers. Analyst 2015; 140(19): 6631-42. doi: 10.1039/C5AN00688K PMID: 26332016
  34. Kusuma GD, Barabadi M, Tan JL, Morton DAV, Frith JE, Lim R. To protect and to preserve: Novel preservation strategies for extracellular vesicles. Front Pharmacol 2018; 9: 1199. doi: 10.3389/fphar.2018.01199 PMID: 30420804
  35. Charoenviriyakul C, Takahashi Y, Nishikawa M, Takakura Y. Preservation of exosomes at room temperature using lyophilization. Int J Pharm 2018; 553(1-2): 1-7. doi: 10.1016/j.ijpharm.2018.10.032 PMID: 30316791
  36. Yuan F, Li YM, Wang Z. Preserving extracellular vesicles for biomedical applications: Consideration of storage stability before and after isolation. Drug Deliv 2021; 28(1): 1501-9. doi: 10.1080/10717544.2021.1951896 PMID: 34259095
  37. Zhang B, Tian X, Hao J, Xu G, Zhang W. Mesenchymal stem cell-derived extracellular vesicles in tissue regeneration. Cell Transplant 2020; 29: 963689720908500. doi: 10.1177/0963689720908500 PMID: 32207341
  38. Aghabozorgi AS, Ahangari N, Eftekhaari TE, et al. Circulating exosomal miRNAs in cardiovascular disease pathogenesis: New emerging hopes. J Cell Physiol 2019; 234(12): 21796-809. doi: 10.1002/jcp.28942 PMID: 31273798
  39. Zheng D, Huo M, Li B, et al. The role of exosomes and exosomal MicroRNA in cardiovascular disease. Front Cell Dev Biol 2021; 8: 616161. doi: 10.3389/fcell.2020.616161 PMID: 33511124
  40. Huang L, Ma W, Ma Y, Feng D, Chen H, Cai B. Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases? Int J Biol Sci 2015; 11(2): 238-45. doi: 10.7150/ijbs.10725 PMID: 25632267
  41. Zhang S, Teo KYW, Chuah SJ, Lai RC, Lim SK, Toh WS. MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis. Biomaterials 2019; 200: 35-47. doi: 10.1016/j.biomaterials.2019.02.006 PMID: 30771585
  42. Wang Y, Yu D, Liu Z, et al. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Ther 2017; 8(1): 189. doi: 10.1186/s13287-017-0632-0 PMID: 28807034
  43. Wu P, Zhang B, Ocansey DKW, Xu W, Qian H. Extracellular vesicles: A bright star of nanomedicine. Biomaterials 2021; 269: 120467. doi: 10.1016/j.biomaterials.2020.120467 PMID: 33189359
  44. Maumus M, Jorgensen C, Noël D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes. Biochimie 2013; 95(12): 2229-34. doi: 10.1016/j.biochi.2013.04.017 PMID: 23685070
  45. Ni Z, Zhou S, Li S, et al. Exosomes: Roles and therapeutic potential in osteoarthritis. Bone Res 2020; 8(1): 25. doi: 10.1038/s41413-020-0100-9 PMID: 32596023
  46. Mihanfar A, Shakouri SK, Khadem-Ansari MH, et al. Exosomal miRNAs in osteoarthritis. Mol Biol Rep 2020; 47(6): 4737-48. doi: 10.1007/s11033-020-05443-1 PMID: 32277444
  47. Bao C, He C. The role and therapeutic potential of MSC-derived exosomes in osteoarthritis. Arch Biochem Biophys 2021; 710: 109002. doi: 10.1016/j.abb.2021.109002 PMID: 34352243
  48. Li Y, Huang P, Nasser MI, Wu W, Yao J, Sun Y. Role of exosomes in bone and joint disease metabolism, diagnosis, and therapy. Eur J Pharm Sci 2022; 176: 106262. doi: 10.1016/j.ejps.2022.106262 PMID: 35850174
  49. Pan Y, Li Y, Dong W, Jiang B, Yu Y, Chen Y. Role of nano-hydrogels coated exosomes in bone tissue repair. Front Bioeng Biotechnol 2023; 11: 1167012. doi: 10.3389/fbioe.2023.1167012 PMID: 37229488
  50. Zou J, Yang W, Cui W, et al. Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon-bone healing. J Nanobiotechnol 2023; 21(1): 14. doi: 10.1186/s12951-023-01778-6 PMID: 36642728
  51. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8(9): 726-36. doi: 10.1038/nri2395 PMID: 19172693
  52. Vakhshiteh F, Atyabi F, Ostad SN. Mesenchymal stem cell exosomes: A two-edged sword in cancer therapy. Int J Nanomedicine 2019; 14: 2847-59. doi: 10.2147/IJN.S200036 PMID: 31114198
  53. Yang J, Zhang X, Chen X, Wang L, Yang G. Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia. Mol Ther Nucleic Acids 2017; 7: 278-87. doi: 10.1016/j.omtn.2017.04.010 PMID: 28624203
  54. Ma ZJ, Yang JJ, Lu YB, Liu ZY, Wang XX. Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine. World J Stem Cells 2020; 12(8): 814-40. doi: 10.4252/wjsc.v12.i8.814 PMID: 32952861
  55. Tajiri K, Shimizu Y. Liver physiology and liver diseases in the elderly. World J Gastroenterol 2013; 19(46): 8459-67. doi: 10.3748/wjg.v19.i46.8459 PMID: 24379563
  56. Zhang S, Hou Y, Yang J, et al. Application of mesenchymal stem cell exosomes and their drug‐loading systems in acute liver failure. J Cell Mol Med 2020; 24(13): 7082-93. doi: 10.1111/jcmm.15290 PMID: 32492261
  57. Ding J, Wang J, Chen J. Exosomes as therapeutic vehicles in liver diseases. Ann Transl Med 2021; 9(8): 735. doi: 10.21037/atm-20-5422 PMID: 33987433
  58. Kučuk N, Primožič M, Knez Ž, Leitgeb M. Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers. Int J Mol Sci 2021; 22(17): 9543. doi: 10.3390/ijms22179543 PMID: 34502452
  59. Massa M, Croce S, Campanelli R, et al. Clinical applications of mesenchymal stem/stromal cell derived extracellular vesicles: Therapeutic potential of an acellular product. Diagnostics 2020; 10(12): 999. doi: 10.3390/diagnostics10120999 PMID: 33255416
  60. Phinney DG, Pittenger MF. Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells 2017; 35(4): 851-8. doi: 10.1002/stem.2575 PMID: 28294454
  61. Chen LY, Kao TW, Chen CC, et al. Frontier review of the molecular mechanisms and current approaches of stem cell-derived exosomes. Cells 2023; 12(7): 1018. doi: 10.3390/cells12071018 PMID: 37048091
  62. Bojanic C, To K, Hatoum A, et al. Mesenchymal stem cell therapy in hypertrophic and keloid scars. Cell Tissue Res 2021; 383(3): 915-30. doi: 10.1007/s00441-020-03361-z PMID: 33386995
  63. Cai Y, Li J, Jia C, He Y, Deng C. Therapeutic applications of adipose cell-free derivatives: A review. Stem Cell Res Ther 2020; 11(1): 312. doi: 10.1186/s13287-020-01831-3 PMID: 32698868
  64. Fang F, Huang RL, Zheng Y, Liu M, Huo R. Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling. J Dermatol Sci 2016; 83(2): 95-105. doi: 10.1016/j.jdermsci.2016.03.003 PMID: 27211019
  65. Xiong M, Zhang Q, Hu W, et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacol Res 2021; 166: 105490. doi: 10.1016/j.phrs.2021.105490 PMID: 33582246
  66. Zhang J, Guan J, Niu X, et al. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med 2015; 13(1): 49. doi: 10.1186/s12967-015-0417-0 PMID: 25638205
  67. Li C, Wei S, Xu Q, Sun Y, Ning X, Wang Z. Application of ADSCs and their exosomes in scar prevention. Stem Cell Rev Rep 2022; 18(3): 952-67. doi: 10.1007/s12015-021-10252-5 PMID: 34510359
  68. Shi H, Wang M, Sun Y, Yang D, Xu W, Qian H. Exosomes: Emerging cell-free based therapeutics in dermatologic diseases. Front Cell Dev Biol 2021; 9: 736022. doi: 10.3389/fcell.2021.736022 PMID: 34722517
  69. Ku YC, Omer Sulaiman H, Anderson SR, Abtahi AR. The potential role of exosomes in aesthetic plastic surgery: A review of current literature. Plast Reconstr Surg Glob Open 2023; 11(6): e5051. doi: 10.1097/GOX.0000000000005051 PMID: 37313480
  70. Zhu Z, Hou Q, Li M, Fu X. Molecular mechanism of myofibroblast formation and strategies for clinical drugs treatments in hypertrophic scars. J Cell Physiol 2020; 235(5): 4109-19. doi: 10.1002/jcp.29302 PMID: 31612497
  71. Ferreira AF, Gomes DA. Stem cell extracellular vesicles in skin repair. Bioengineering 2018; 6(1): 4. doi: 10.3390/bioengineering6010004 PMID: 30598033
  72. Shen X, Song S, Chen N, Liao J, Zeng L. Stem cell‐derived exosomes: A supernova in cosmetic dermatology. J Cosmet Dermatol 2021; 20(12): 3812-7. doi: 10.1111/jocd.14438 PMID: 34536054
  73. Gao W, Yuan L, Zhang Y, et al. miR-1246-overexpressing exosomes suppress UVB-induced photoaging via regulation of TGF-β/Smad and attenuation of MAPK/AP-1 pathway. Photochem Photobiol Sci 2022; 22(1): 135-46. doi: 10.1007/s43630-022-00304-1 PMID: 36114328
  74. Wu JY, Wu SN, Zhang LP, et al. Stem cell-derived exosomes: A new method for reversing skin aging. Tissue Eng Regen Med 2022; 19(5): 961-8. doi: 10.1007/s13770-022-00461-5 PMID: 35809187
  75. Jiang L, Zhang S, Hu H, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages. Biochem Biophys Res Commun 2019; 508(3): 735-41. doi: 10.1016/j.bbrc.2018.11.189 PMID: 30528233
  76. Ibsen SD, Wright J, Lewis JM, et al. Rapid isolation and detection of exosomes and associated biomarkers from plasma. ACS Nano 2017; 11(7): 6641-51. doi: 10.1021/acsnano.7b00549 PMID: 28671449
  77. van der Pol E, Coumans F, Varga Z, Krumrey M, Nieuwland R. Innovation in detection of microparticles and exosomes. J Thromb Haemost 2013; 11 (Suppl. 1): 36-45. doi: 10.1111/jth.12254 PMID: 23809109
  78. Raj DAA, Fiume I, Capasso G, Pocsfalvi G. A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Kidney Int 2012; 81(12): 1263-72. doi: 10.1038/ki.2012.25 PMID: 22418980
  79. Zhang X, Liu J, Yu B, Ma F, Ren X, Li X. Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes. Graefes Arch Clin Exp Ophthalmol 2018; 256(11): 2041-52. doi: 10.1007/s00417-018-4097-3 PMID: 30167916
  80. Greening DW, Xu R, Ji H, Tauro BJ, Simpson RJ. A protocol for exosome isolation and characterization: Evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol 2015; 1295: 179-209. doi: 10.1007/978-1-4939-2550-6_15 PMID: 25820723
  81. Kırbaş OK, Bozkurt BT, Asutay AB, et al. Optimized isolation of extracellular vesicles from various organic sources using aqueous two-phase system. Sci Rep 2019; 9(1): 19159. doi: 10.1038/s41598-019-55477-0 PMID: 31844310
  82. Ding M, Shen Y, Wang P, et al. Exosomes isolated from human umbilical cord mesenchymal stem cells alleviate neuroinflammation and reduce amyloid-beta deposition by modulating microglial activation in alzheimer’s disease. Neurochem Res 2018; 43(11): 2165-77. doi: 10.1007/s11064-018-2641-5 PMID: 30259257
  83. Yu B, Shao H, Su C, et al. Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1. Sci Rep 2016; 6(1): 34562. doi: 10.1038/srep34562 PMID: 27686625
  84. Shin H, Han C, Labuz JM, et al. High-yield isolation of extracellular vesicles using aqueous two-phase system. Sci Rep 2015; 5(1): 13103. doi: 10.1038/srep13103 PMID: 26271727
  85. Han BH, Kim S, Seo G, Heo Y, Chung S, Kang JY. Isolation of extracellular vesicles from small volumes of plasma using a microfluidic aqueous two-phase system. Lab Chip 2020; 20(19): 3552-9. doi: 10.1039/D0LC00345J PMID: 32808641
  86. Wang B, Jia H, Zhang B, et al. Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy. Stem Cell Res Ther 2017; 8(1): 75. doi: 10.1186/s13287-016-0463-4 PMID: 28388958
  87. Oksvold MP, Neurauter A, Pedersen KW. Magnetic bead-based isolation of exosomes. Methods Mol Biol 2015; 1218: 465-81. doi: 10.1007/978-1-4939-1538-5_27 PMID: 25319668
  88. Shiue SJ, Rau RH, Shiue HS, et al. Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury-induced pain in rats. Pain 2019; 160(1): 210-23. doi: 10.1097/j.pain.0000000000001395 PMID: 30188455
  89. Barwari T, Joshi A, Mayr M. MicroRNAs in cardiovascular disease. J Am Coll Cardiol 2016; 68(23): 2577-84. doi: 10.1016/j.jacc.2016.09.945 PMID: 27931616
  90. Cheng C, Chen X, Wang Y, et al. MSCs derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6. Mol Med 2021; 27(1): 67. doi: 10.1186/s10020-021-00324-0 PMID: 34215174
  91. Ye Z, Hu J, Xu H, et al. Serum exosomal microRNA-27-3p aggravates cerebral injury and inflammation in patients with acute cerebral infarction by targeting PPARγ. Inflammation 2021; 44(3): 1035-48. doi: 10.1007/s10753-020-01399-3 PMID: 33394189
  92. Endisha H, Datta P, Sharma A, et al. MicroRNA‐34a‐5p promotes joint destruction during osteoarthritis. Arthritis Rheumatol 2021; 73(3): 426-39. doi: 10.1002/art.41552 PMID: 33034147
  93. Rego-Pérez I, Durán-Sotuela A, Ramos-Louro P, Blanco FJ. Genetic biomarkers in osteoarthritis: A quick overview. Fac Rev 2021; 10: 78. doi: 10.12703/r/10-78 PMID: 35028644

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