Mitochondrial Transplantation and Immune Response of Human Bone Marrow Mesenchymal Stem Cells for the Therapeutic of Ischemic Stroke


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Abstract

Ischemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and recovery after stroke, when combined with the intracranial and extracranial immunoregulatory effects of stem cell therapy, revealing the mechanism of transferred mitochondria in stem cells in protecting neurological function among chronic-phase ischemic stroke by affecting the endogenous apoptotic pathway of neuronal cells. This research elaborated on the mitochondrial dysfunction in neurons after ischemic stroke, followed by human bone marrow mesenchymal stem cells (hBMSC) rescued damaged neurons by mitochondrial transfer through tunneling nanotubes (TNTs), and the immunomodulatory effect of the preferential transfer of stem cells to the spleen when transplanted into the body，which created an immune environment for nerve repair, as well as improved neurological recovery after the chronic phase of stroke. This review is expected to provide a novel idea for applying intracranial stem cell transplantation in chronic-phase ischemic stroke treatment.

About the authors

Yidong Liao

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Jiang Ming

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Wenxue Song

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Guangtang Chen

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Junshuan Cui

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Longcai He

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Zili Wang

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Xudong Wang

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Mingsong Xiong

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Email: info@benthamscience.net

Hua Yang

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Author for correspondence.
Email: info@benthamscience.net

Kaya Xu

Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University

Author for correspondence.
Email: info@benthamscience.net

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