Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet Transplantation


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Abstract

Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin expression, processing, and secretion. Exo-miRNAs have a significant impact on the outcomes of islet transplantation as biomarkers for evaluating islet cell function and survival. Furthermore, they have been linked to vascular remodeling and immune regulation following islet transplantation. Mesenchymal stem cell-derived exosomes have been shown in preliminary studies to improve islet cell viability and function when injected or transplanted into mice. Overall, Exo-miRNAs have emerged as novel agents for improving islet transplantation success rates. The role of islet-derived Exo-miRNAs and mesenchymal stem cells-derived Exo-miRNAs as biomarkers and immunomodulators in islet regeneration, as well as their role in improving islet cell viability and function in islet transplantation, are discussed in this review.

About the authors

Qiu Minhua

Graduate School, Guangxi Traditional Chinese Medical University

Email: info@benthamscience.net

Feng Bingzheng

Ruikang Hospital, Guangxi Traditional Chinese Medical University

Email: info@benthamscience.net

Xu Zhiran

Ruikang Hospital, Guangxi Traditional Chinese Medical University

Email: info@benthamscience.net

Zhang Yingying

Department of Foreign Languages, Guangxi Traditional Chinese Medical University

Email: info@benthamscience.net

Yang Yuwei

Graduate School, Guangxi University of Chinese Medicine

Email: info@benthamscience.net

Zhang Ting

Ruikang Hospital, Guangxi Traditional Chinese Medical University

Email: info@benthamscience.net

Chen Jibing

Ruikang Hospital, Guangxi Traditional Chinese Medical University

Author for correspondence.
Email: info@benthamscience.net

Gao Hongjun

Ruikang Hospital,, Guangxi University of Chinese Medicine

Author for correspondence.
Email: info@benthamscience.net

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