Comparison of Periodontal Ligament Stem Cells with Mesenchymal Stem Cells from Other Sources: A Scoping Systematic Review of In vitro and In vivo Studies

  • Authors: Kadkhoda Z.1, Motie P.2, Rad M.3, Mohaghegh S.4, Kouhestani F.5, Motamedian S.6
  • Affiliations:
    1. Department of Periodontology, School of Dentistry,, Shahid Beheshti University of Medical Science
    2. OrthStudent Research Committee, School of Dentistryodontics, Shahid Beheshti University of Medical Science
    3. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences
    4. Student Research Committee, School of Dentistry,, Shahid Beheshti University of Medical Science
    5. Department of Periodontics, School of Dentistry,, Bushehr University of Medical Sciences
    6. Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences
  • Issue: Vol 19, No 4 (2024)
  • Pages: 497-522
  • Section: Medicine
  • URL: https://rjpbr.com/1574-888X/article/view/645792
  • DOI: https://doi.org/10.2174/1574888X17666220429123319
  • ID: 645792

Cite item

Full Text

Abstract

Objective:The application of stem cells in regenerative medicine depends on their biological properties. This scoping review aimed to compare the features of periodontal ligament stem cells (PDLSSCs) with stem cells derived from other sources.

Design:An electronic search in PubMed/Medline, Embase, Scopus, Google Scholar and Science Direct was conducted to identify in vitro and in vivo studies limited to English language.

Results:Overall, 65 articles were included. Most comparisons were made between bone marrow stem cells (BMSCs) and PDLSCs. BMSCs were found to have lower proliferation and higher osteogenesis potential in vitro and in vivo than PDLSCs; on the contrary, dental follicle stem cells and umbilical cord mesenchymal stem cells (UCMSCs) had a higher proliferative ability and lower osteogenesis than PDLSCs. Moreover, UCMSCs exhibited a higher apoptotic rate, hTERT expression, and relative telomerase length. The immunomodulatory function of adipose-derived stem cells and BMSCs was comparable to PDLSCs. Gingival mesenchymal stem cells showed less sensitivity to long-term culture. Both pure and mixed gingival cells had lower osteogenic ability compared to PDLSCs. Comparison of dental pulp stem cells (DPSCs) with PDLSCs regarding proliferation rate, osteo/adipogenesis, and immunomodulatory properties was contradictory; however, in vivo bone formation of DPSCs seemed to be lower than PDLSCs.

Conclusion:In light of the performed comparative studies, PDLSCs showed comparable results to stem cells derived from other sources; however, further in vivo studies are needed to determine the actual pros and cons of stem cells in comparison to each other.

About the authors

Zeinab Kadkhoda

Department of Periodontology, School of Dentistry,, Shahid Beheshti University of Medical Science

Email: info@benthamscience.net

Parisa Motie

OrthStudent Research Committee, School of Dentistryodontics, Shahid Beheshti University of Medical Science

Email: info@benthamscience.net

Maryam Rad

Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Sadra Mohaghegh

Student Research Committee, School of Dentistry,, Shahid Beheshti University of Medical Science

Email: info@benthamscience.net

Farnaz Kouhestani

Department of Periodontics, School of Dentistry,, Bushehr University of Medical Sciences

Email: info@benthamscience.net

Saeed Motamedian

Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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