Emerging Role of miRNAs in the Pathogenesis of Periodontitis


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MicroRNAs (miRNAs) have been found to participate in the pathogenesis of several immune-related conditions through the modulation of the expression of cytokine coding genes and other molecules that affect the activity of the immune system. Periodontitis is an example of these conditions associated with the dysregulation of several miRNAs. Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. miR-146 is the most assessed miRNA in these patients, which is up-regulated in most studies in patients with periodontitis. In the present review, we describe the impact of miRNAs dysregulation on the pathoetiology of periodontitis.

作者简介

Mohammad Taheri

Urology and Nephrology Research Center,, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Tayyebeh Khoshbakht

Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Bashdar Hussen

Department of Pharmacognosy, College of Pharmacy, Hawler Medical University

Email: info@benthamscience.net

Sara Abdullah

Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University,

Email: info@benthamscience.net

Soudeh Ghafouri-Fard

Department of Medical Genetics, School of Medicine, S, Shahid Beheshti University of Medical Sciences

编辑信件的主要联系方式.
Email: info@benthamscience.net

Arezou Sayad

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences

编辑信件的主要联系方式.
Email: info@benthamscience.net

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