The Current Status and Future Direction of Extracellular Nano-vesicles in the Alleviation of Skin Disorders


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Abstract

Exosomes are extracellular vesicles (EVs) that originate from endocytic membranes. The transfer of biomolecules and biological compounds such as enzymes, proteins, RNA, lipids, and cellular waste disposal through exosomes plays an essential function in cell-cell communication and regulation of pathological and physiological processes in skin disease. The skin is one of the vital organs that makes up about 8% of the total body mass. This organ consists of three layers, epidermis, dermis, and hypodermis that cover the outer surface of the body. Heterogeneity and endogeneity of exosomes is an advantage that distinguishes them from nanoparticles and liposomes and leads to their widespread usage in the remedy of dermal diseases. The biocompatible nature of these extracellular vesicles has attracted the attention of many health researchers. In this review article, we will first discuss the biogenesis of exosomes, their contents, separation methods, and the advantages and disadvantages of exosomes. Then we will highlight recent developments related to the therapeutic applications of exosomes in the treatment of common skin disorders like atopic dermatitis, alopecia, epidermolysis bullosa, keloid, melanoma, psoriasis, and systemic sclerosis.

About the authors

Raziyeh Ghorbani

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Simzar Hosseinzadeh

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Arezo Azari

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Niloofar Taghipour

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine,, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Masoud Soleimani

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Azam Rahimpour

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine,, Shahid Beheshti University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Hojjat Abbaszadeh

Laser Application in Medical Sciences Research Center,, Shahid Beheshti University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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