Meta-analysis of the Impact of Bariatric Surgery on Circulating TMAO Levels as a Predictor of Cardiovascular Disease Risk


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Introduction:Trimethylamine N-oxide (TMAO) is a metabolite of the gut microbiota that is considered a cardiovascular risk factor. Because bariatric surgery (BS) produces changes in the composition of the gut microbiota, the production of TMAO can be compromised. Thus, the purpose of this meta-analysis was to determine the effect of BS on circulating TMAO levels.

Methods:A systematic search was carried on in Embase, PubMed, Web of Science, and Scopus databases. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V2 software. The overall effect size was determined by a random-effects metaanalysis and the leave-one-out approach.

Results:Random-effects meta-analysis of 5 studies consisting of 142 subjects demonstrated a significant increase in circulating TMAO levels after BS (SMD: 1.190, 95% CI: 0.521, 1.858, p(<0.001; I2:89.30%).

Conclusion:Considering that levels of TMAO are affected after BS due to gut microbial metabolism alteration, there has been a significant elevation in TMAO concentrations observed to occur after BS in obese subjects.

Sobre autores

Tannaz Jamialahmadi

Applied Biomedical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Luis Simental-Mendia

Biomedical Research Unit, Mexican Social Security Institute

Email: info@benthamscience.net

Gokhan Zengin

Department of Biology, Science Faculty, Selcuk University

Email: info@benthamscience.net

Wael Almahmeed

Heart and Vascular Institute, Cleveland Clinic Abu Dhabi

Email: info@benthamscience.net

Prashant Kesharwani

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard

Email: info@benthamscience.net

Amirhossein Sahebkar

Applied Biomedical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences,

Autor responsável pela correspondência
Email: info@benthamscience.net

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