Berberine: Pharmacological Features in Health, Disease and Aging


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Abstract

Background:Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found in barks and roots of numerous plants. It exhibits a wide range of pharmacological effects, such as anti-obesity and antidiabetic effects. Berberine has antibacterial activity against a variety of microbiota, including many bacterial species, protozoa, plasmodia, fungi, and trypanosomes.

Objective:This review describes the role of berberine and its metabolic effects. It also discusses how it plays a role in glucose metabolism, fat metabolism, weight loss, how it modulates the gut microbiota, and what are its antimicrobial properties along with its potential side effects with maximal tolerable dosage.

Methods:Representative studies were considered and analyzed from different scientific databases, including PubMed and Web of Science, for the years 1982-2022.

Results:Literature analysis shows that berberine affects many biochemical and pharmacological pathways that theoretically yield a positive effect on health and disease. Berberine exhibits neuroprotective properties in various neurodegenerative and neuropsychological ailments. Despite its low bioavailability after oral administration, berberine is a promising tool for several disorders. A possible hypothesis would be the modulation of the gut microbiome. While the evidence concerning the aging process in humans is more limited, preliminary studies have shown positive effects in several models.

Conclusion:Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis for scientists to establish clinical trials in humans. However, for obesity, the evidence appears to be sufficient for hands-on use.

About the authors

Amin Gasmi

, Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée

Email: info@benthamscience.net

Farah Asghar

Department of Microbiology and Molecular Genetics (MMG), University of the Punjab

Email: info@benthamscience.net

Saba Zafar

Department of Research, The Women University

Email: info@benthamscience.net

Petro Oliinyk

, Danylo Halytsky Lviv National Medical University,

Email: info@benthamscience.net

Oksana Khavrona

, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Roman Lysiuk

, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Massimiliano Peana

Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari

Email: info@benthamscience.net

Salva Piscopo

, Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée

Email: info@benthamscience.net

Halyna Antonyak

Department of Ecology,, Ivan Franko National University of Lviv

Email: info@benthamscience.net

Joeri Pen

Diabetes Clinic, Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB)

Email: info@benthamscience.net

Iryna Lozynska

, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Sadaf Noor

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University

Email: info@benthamscience.net

Larysa Lenchyk

Department of Research, National University of Pharmacy

Email: info@benthamscience.net

Akram Muhammad

MedicineDepartment of Research,, Government College University

Email: info@benthamscience.net

Inna Vladimirova

Department of Research, National University of Pharmacy

Email: info@benthamscience.net

Natalia Dub

, Andrei Krupynskyi Lviv Medical Academy

Email: info@benthamscience.net

Olha Antoniv

, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Oksana Tsal

, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Taras Upyr

Department of Research, National University of Pharmacy

Email: info@benthamscience.net

Geir Bjørklund

, Council for Nutritional and Environmental Medicine (CONEM)

Author for correspondence.
Email: info@benthamscience.net

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