Synthesis and Comparative Study of Silicone Composites Containing Sodium Diclofenac Using New Types of Cross-Linking Agents

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Abstract

A new type of silicone composites in the form of films containing sodium diclofenac were obtained, which can potentially be used as transdermal patches. Glycerol and propylene glycol analogues of tetraethoxysilane, tetrakis(2,3-dihydroxypropoxy)silane and tetrakis(2-hydroxypropoxy)silane, were first used to cure polydimethylsiloxane with terminal hydroxyl groups (PDMS-OH) to obtain silicone composites. It was shown that these cross-linking agents have a number of advantages over tetraethoxysilane.

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About the authors

M. L. Atabekyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-5265-5469
Armenia, Yerevan, 0014

Z. M. Farmazyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0001-9841-5586
Armenia, Yerevan, 0014

E. A. Hakopyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0003-2409-1894
Armenia, Yerevan, 0014

M. S. Torosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0009-0008-3399-2137
Armenia, Yerevan, 0014

V. O. Topuzyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-1721-1993
Armenia, Yerevan, 0014

S. G. Grigoryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Author for correspondence.
Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-7193-9803
Armenia, Yerevan, 0014

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2. Scheme 1.

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3. Fig. 1. Kinetics of diclofenac desorption from composites 1-4 in phosphate buffer (pH = 6.86) (a) and 0.9% NaCl solution (b). The standard deviations of R2 measurements for the curves of the graphs are: (a) 0.97-0.98 and (b) 0.99.

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4. Fig. 2. Kinetics of diclofenac desorption from composites No. 6-8 in buffer (a) and 0.9% NaCl solution (b). The standard deviations of R2 measurements for the curves of the graphs are: (a) 0.98 and (b) 0.94-0.98.

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5. Fig. 3. Kinetics of diclofenac desorption from optimal composites No. 8 (TDGPS-G sample) and No. 9 (TDGPS-K sample) in phosphate buffer (1 - TDGPS-G, 2 - TDGPS-K) and 0.9% NaCl solution (3 - TDGPS-G, 4 - TDGPS-K). The standard deviations of R2 measurements for the graph curves are 0.96-0.98.

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6. Fig. 4. SEM images of composite films No. 8 (TDGPS-G sample) (left column) and No. 9 (TDGPS-K sample) (right column).

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7. Fig. 5. The first mapping region of composite No. 8.

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8. Fig. 6. Second mapping region of composite No. 8.

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9. Fig. 7. The third mapping region of composite No. 8.

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10. Table 4_Fig. 1

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11. Table 4_Fig. 2

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12. Table 4_Fig. 3

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