Synthesis and Comparative Study of Silicone Composites Containing Sodium Diclofenac Using New Types of Cross-Linking Agents

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

A new type of silicone composites in the form of films containing sodium diclofenac were obtained, which can potentially be used as transdermal patches. Glycerol and propylene glycol analogues of tetraethoxysilane, tetrakis(2,3-dihydroxypropoxy)silane and tetrakis(2-hydroxypropoxy)silane, were first used to cure polydimethylsiloxane with terminal hydroxyl groups (PDMS-OH) to obtain silicone composites. It was shown that these cross-linking agents have a number of advantages over tetraethoxysilane.

全文:

受限制的访问

作者简介

M. Atabekyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-5265-5469
亚美尼亚, Yerevan, 0014

Z. Farmazyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0001-9841-5586
亚美尼亚, Yerevan, 0014

E. Hakopyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0003-2409-1894
亚美尼亚, Yerevan, 0014

M. Torosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0009-0008-3399-2137
亚美尼亚, Yerevan, 0014

V. Topuzyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-1721-1993
亚美尼亚, Yerevan, 0014

S. Grigoryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

编辑信件的主要联系方式.
Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-7193-9803
亚美尼亚, Yerevan, 0014

参考

  1. Haley R.M., von Recum H.A. // Exp. Biol. Med. 2019. Vol. 244. P. 433. doi: 10.1177/1535370218787770
  2. Blanca-Lopez N., Soriano V., Garcia-Martin E., Canto G., Blanca M. // J. Asthma Allergy. 2019. Vol. 12. P. 217. doi: 10.2147/JAA.S164806
  3. McGettigan P., Henry D. // PLoS Medicine. 2013. Vol. 10. N 2. P. 1. e1001388. doi: 10.1371/journal.pmed.1001388
  4. Davis A., Robson J. // British J. Gen. Pract. 2016. Vol. 66. P. 172. doi: 10.3399/bjgp16X684433
  5. Awachat A., Shukla D., Bhola N.D. // Cureus. 2022. Vol. 14. P. e30411. doi: 10.7759/cureus.30411
  6. Kapo S.M., Rakanović-Todić M., Burnazović-Ristić L., Kusturica J., Ćesić A.K., Ademović E., Aganović-Mušinović I. // J. King Saud Univ. Sci. 2023. Vol. 35. N 1. P. 102394. doi: 10.1016/j.jksus.2022.102394
  7. Snorradottir B.S., Gudnason P.I., Scheving R., Thorsteinsson F., Masson M. // Pharmazie. 2009. Vol. 64. P. 19. doi: 10.1691/ph.2008.8206
  8. Ailincai D., Dorobanțu A.M., Dima B., Irimiciuc Ș.A., Lupașcu C., Agop M., Olguta O. // J. Immunol. Res. 2020. P. 1. doi: 10.1155/2020/3124304
  9. Sa’adon S., Ansari M.N.M., Razak S.I.A., Anand J.S., Nayan N.H.M., Ismail A.E., Haider A. // Polymer. 2021. Vol. 15. P. 2459. doi: 10.3390/polym13152459
  10. Stewart S.A., Domínguez-Robles J., Donnelly R.F., Larrañeta E. // Polymer. 2018. Vol. 10. N 12. P. 1379. doi: 10.3390/polym10121379
  11. Soroory H., Mashak A., Rahimi A. // Iran. Polym. J. 2013. Vol. 22. P. 791. doi: 10.1007/s13726-013-0178-7
  12. Mashak A., Rahimi A. // Iran. Polym. J. 2009. Vol. 18. N 4. P. 279.
  13. Mikolaszek B., Kazlauske J., Larsson A., Sznitowska M. // Polymer. 2020. Vol. 12. N 7. P. 1520. doi: 10.3390/polym12071520
  14. Gafar Ahmed M., AlHammad Z.A., Al-Jandan B. // Cureus. 2023. Vol. 15. N 2. P. e 34524.
  15. Mojsiewicz-Pieńkowska K. // Handbook of Polymers for Pharmaceutical Technologies, 2015. Vol. 2. P. 363. doi: 10.1002/9781119041412
  16. Aliyar H., Schalau G. 2nd // Therapeutic Deliv. 2015. Vol. 6. N 7. P. 827. doi: 10.4155/tde.15.39
  17. Snorradottir B.S., Gudnason P.I., Scheving R., Thorsteinsson F., Masson M. // Pharmazie. 2009. Vol. 64. P. 19. https://doi.org/10.1691/ph.2008.8206
  18. Malcolm R., McCullagh S., Woolfson A., Gorman S., Jones D., Cuddy J. // J. Control. Release. 2003. Vol. 97. P. 313. doi: 10.1016/j.jconrel.2004.03.029
  19. Mark J.E., Sullivan J.L. // J. Chem. Phys. 1977. Vol. 66. P. 1006. doi: 10.1063/1.434056
  20. Brook M.A., Holloway A.C., Kenneth K.N., Hrynyk M., Moore C., Ryan L. // Int. J. Pharm. 2008. Vol. 358. P. 121. doi: 10.1016/j.ijpharm.2008.02.029
  21. Soulas D.N., Sanopoulou M., Papadokostaki K.G. // Mater. Sci. Eng. 2013. Vol. C33. P. 2122. doi 10.1016/ j.msec.2013.01.031
  22. Mark J.E., Jiang C.Y., Tang M.Y. // Macromolecules. 1984. Vol. 17. P. 2613. doi: 10.1021/ma00142a026
  23. Yuan Q.W., Mark J.E. // Macromol. Chem. Phys. 1999. Vol. 200. P. 206. doi: 10.1002/(SICI)1521-3935(19990101) 200:1%3C206::AID-MACP206%3E3.0.CO;2-S
  24. Robinson M.W.C., Swain A.C., Khan N.A. // Polym. Degrad. Stab. 2015. Vol. 116. P. 88. doi 10.1016/ j.polymdegradstab.2013.10.011
  25. Rajendra V., Chen Y., Brook M.A. // Polym. Chem. 2010. Vol. 1. P. 312. doi: 10.1039/B9PY00220K
  26. Чупахин О.Н., Хонина Т.Г., Ларионов Л.П., Шадрина Е.В., Бойко А.А., Забокрицкий Н.А., Волков А.А. Пат. РФ 2382046 С1; Б. И. 2010. № 5
  27. Atabekyan M.L., Farmazyan Z.M., Grigoryan S.G., Lavanant L., Topuzyan V.O. Pat. EU 4322906 (2024); Pat. JP2024514128A (2024).
  28. Mazurek A., Brook M.A., Skov A.L. // Langmuir. 2018. Vol. 34. P. 11559. doi 0.1021/acs.langmuir.8b02039
  29. Григорян С.Г., Акопян Э.А., Акобян Р.М., Фармазян З.М., Атабекян М.Л., Топузян В.О. // ЖОХ. 2023. Т. 93. № 8. С. 1281. doi: 10.31857/S0044460X23080139; Grigoryan S.G., Hakopyan E.H., Hakobyan R.M., Farmazyan Z.M., Atabekyan M.L., Topuzyan V.O. // Russ. J. Gen. Chem. 2023. Vol. 93. N 8. P. 2048. doi: 10.1134/S1070363223080133
  30. Mercier K., Brule Th., Fromentoux L. Quality control of sugar content in beverages using Raman spectroscopy. https://www.horiba.com/

补充文件

附件文件
动作
1. JATS XML
下载
2. Scheme 1.

下载 (146KB)
索引源数据
3. Fig. 1. Kinetics of diclofenac desorption from composites 1-4 in phosphate buffer (pH = 6.86) (a) and 0.9% NaCl solution (b). The standard deviations of R2 measurements for the curves of the graphs are: (a) 0.97-0.98 and (b) 0.99.

下载 (5KB)
索引源数据
4. Fig. 2. Kinetics of diclofenac desorption from composites No. 6-8 in buffer (a) and 0.9% NaCl solution (b). The standard deviations of R2 measurements for the curves of the graphs are: (a) 0.98 and (b) 0.94-0.98.

下载 (4KB)
索引源数据
5. Fig. 3. Kinetics of diclofenac desorption from optimal composites No. 8 (TDGPS-G sample) and No. 9 (TDGPS-K sample) in phosphate buffer (1 - TDGPS-G, 2 - TDGPS-K) and 0.9% NaCl solution (3 - TDGPS-G, 4 - TDGPS-K). The standard deviations of R2 measurements for the graph curves are 0.96-0.98.

下载 (2KB)
索引源数据
6. Fig. 4. SEM images of composite films No. 8 (TDGPS-G sample) (left column) and No. 9 (TDGPS-K sample) (right column).

下载 (157KB)
索引源数据
7. Fig. 5. The first mapping region of composite No. 8.

下载 (53KB)
索引源数据
8. Fig. 6. Second mapping region of composite No. 8.

下载 (51KB)
索引源数据
9. Fig. 7. The third mapping region of composite No. 8.

下载 (59KB)
索引源数据
10. Table 4_Fig. 1

下载 (17KB)
索引源数据
11. Table 4_Fig. 2

下载 (27KB)
索引源数据
12. Table 4_Fig. 3

下载 (29KB)
索引源数据

版权所有 © Russian Academy of Sciences, 2024