Антивозрастная медицина: митохондриально-направленные антиоксиданты и физическая нагрузка

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Митохондрии – важный источник активных форм кислорода в скелетных мышцах. Митохондриальная дисфункция сопутствует развитию возрастных заболеваний человека. Повышенная продукция активных форм кислорода способствует мышечной атрофии, вызванной, например, отсутствием физической активности. Многие регулирующие пути, участвующие в биогенезе митохондрий, становятся мишенями антивозрастной терапии. Активный образ жизни и физические упражнения препятствуют возрастному повреждению митохондрий скелетных мышц. Другой способ коррекции действия активных форм кислорода – применение антиоксидантов, направленных непосредственно в митохондрии. Лечение митохондриально-направленными антиоксидантами ослабляет митохондриальную дегенерацию, улучшает возрастную функцию скелетных мышц и защищает мышцы от атрофии. Представлены данные о применении митохондриально-направленных антиоксидантов и физических упражнений для поддержания структурно-функционального состояния митохондрий и о защите мышц от саркопении.

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Г. А. Шиловский

Московский государственный университет им. М.В. Ломоносова

Автор, ответственный за переписку.
Email: gregory_sh@list.ru

биологический факультет

Россия, Москва

Е. В. Сорокина

Московский государственный университет им. М.В. Ломоносова

Email: evsorokina77@mail.ru

биологический факультет

Россия, Москва

Д. Н. Ахаев

Московский государственный университет им. М.В. Ломоносова

Email: gregory_sh@list.ru

биологический факультет

Россия, Москва

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