Biological prophylaxis in the system of the management of occupational risk due to exposure of metal-containing nanoparticles

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Abstract

With taking into account the biological toxicity of metallic and metal oxide nanoparticles to be a well-established fact, the widespread use of nanotechnologies and the significant proportion of nanoscale particles in industrial aerosols released during many pyrometallurgical and electric welding processes determine the importance of searching for approaches to increase the organism’s resistance to them. Results of a number of experiments show the application of combinations of some bioactive agents composed in accordance with sound theoretical premises and used in innocuous doses to be potent of the significant attenuation of the integral and specific toxicity of metallic nanoparticles and even their genotoxicity. Further research followed by practical application of the results is a promising trend in the occupational risk management strategy.

About the authors

Larisa I. Privalova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: privalovali@yahoo.com
ORCID iD: 0000-0002-1442-6737

MD, PhD,  DSci., Professor Head of Laboratory  of Scientific Bases for Biological Prophylaxis, Department of the Toxicology and Biological Prophylaxis, the Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, 620014, Russian Federation.

e-mail: privalovali@yahoo.com

Russian Federation

B. A. Katsnelson

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0001-8750-9624
Russian Federation

I. A. Minigalieva

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0097-7845
Russian Federation

M. P. Sutunkova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1743-7642
Russian Federation

O. G. Makeev

The Central Research Laboratory of the Ural Medical University

Email: noemail@neicon.ru
Russian Federation

I. E. Valamina

The Central Research Laboratory of the Ural Medical University

Email: noemail@neicon.ru
Russian Federation

V. Ya. Shur

Ural Federal University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-6970-7798
Russian Federation

S. V. Klinova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0927-4062
Russian Federation

S. N. Solovyeva

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0001-8580-403X
Russian Federation

References

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Copyright (c) 2024 Privalova L.I., Katsnelson B.A., Minigalieva I.A., Sutunkova M.P., Makeev O.G., Valamina I.E., Shur V.Y., Klinova S.V., Solovyeva S.N.



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