Issues of pathogenetic relationships between neurochemical indices under the chronic mercury exposure
- Authors: Kudaeva I.V.1, Naumova O.V.1, Dyakovich O.A.1, Masnavieva L.B.1
-
Affiliations:
- East-Siberian Institute of Medical and Ecological Research
- Issue: Vol 99, No 10 (2020)
- Pages: 1127-1131
- Section: OCCUPATIONAL HEALTH
- Published: 01.12.2020
- URL: https://rjpbr.com/0016-9900/article/view/638507
- DOI: https://doi.org/10.47470/0016-9900-2020-99-10-1127-1131
- ID: 638507
Cite item
Full Text
Abstract
Introduction. Currently, the role of neurochemical factors in the pathogenesis of disorders caused by mercury exposure remains unclear.
Material and methods. A survey was conducted of 77 male patients (average age: 45.4+1.1 years, average experience - 17.1+1.1 years) exposed to mercury vapor (46 persons without pathology, 31 - with signs of disorders in the nervous system), 36 patients were diagnosed with chronic mercury intoxication (CMI) in the long-term period. We determined dopamine (DA), noradrenaline (NA), epinephrine (AD), normetanephrine (NMN), metanephrine (MN), serotonin (SER), histamine (HIST), brain neurotrophic factor (BDNF), neurotrophic factor 3 (NT-3), ciliary neurotrophic factor (CNTF), and neuron-specific enolase. The analysis of features correlations was calculated by the sum of the square of correlation relations (∑ŋ) between indices and the determination of the influence and dependence ranks for each component.
Results. In workers without signs of pathology, the leading role among catecholamines was occupied by NA (∑ŋЗ/NA = 1.65), in the general system the top position belonged to HIST (∑ŋЗ/HIST = 2.10), SER had a minimum value (∑ŋЗ/SER = 0). In individuals with signs of disorders in the nervous system, AD and DA were regulated via NMN (ŋAD/NMN = 0.29) and MN (ŋAD/MN = 0.59 and ηDA/MN = 0.46), which had an upper position in the system (∑ŋЗ/NMN = 1.62 and ∑ηЗ/MN = 1.92). CNTF belonged to the determining position among neurotrophic factors (∑ŋЗ/CNTF = 0.75). In patients with CMI, NA (∑ŋЗ/NA = 1.48) was the leading position. SER and HIST occupied the lowest ranking position (∑ŋЗ/SER = 0.59 and ∑ŋЗ/HIST = 0.25). The presence of three closed subsystems is established. In one of them (NT-3, CNTF, and BDNF), BDNF was influenced by other factors.
Discussion. The interdependence between neurochemical indices specifyie their involvement in the pathological process of disorders in the central nervous system under chronic mercury exposure.
Conclusion. Changes in the interdependencies in the system of neurochemical indices under the influence of mercury have a labile character, which determines the development of clinical manifestations of the disorders of the nervous system.
About the authors
Irina V. Kudaeva
East-Siberian Institute of Medical and Ecological Research
Author for correspondence.
Email: kudaeva_irina@mail.ru
ORCID iD: 0000-0002-5608-0818
MD, Ph.D., DSci., associate professor, Deputy Director for scientific work, head of the Clinical Diagnostic Laboratory, East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.
у-mail: kudaeva_irina@mail.ru
Russian FederationOlga V. Naumova
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-5353-2268
Russian Federation
Olga A. Dyakovich
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-4903-1401
Russian Federation
Liudmila B. Masnavieva
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-1400-6345
Russian Federation
References
- Rukavishnikov V.S., Lakhman O.L., Sosedova L.M., Shayakhmetov S.F., Bodienkova G.M., Kudaeva I.V., et al. Occupational neurointoxications: patterns and mechanisms of formation. Meditsina truda i promyshlennaya ekologiya. 2014; (4): 1–6. (in Russian)
- Katamanova E.V., Shevchenko O.I., Lakhman O.L., Brezhneva I.A., Proskokov K.M. Disorders of higher psychical functions in encephalopathy of different genesis. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk. 2012; (1): 26–31. (in Russian)
- Escartin C., Pierre K., Colin A., Brouillet E., Delzescaux Th., Guillermier M., et al. Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. J. Neurosci. 2007; 27(27): 7094–104. https://doi.org/10.1523/JNEUROSCI.0174-07.2007
- Escartin C., Boyer F., Bemelmans A.P., Hantraye P., Brouillet E. IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats. Neurosci. Lett. 2007; 425(3): 167–72. https://doi.org/10.1016/j.neulet.2007.08.031
- Burkhalter J., Fiumelli H., Erickson J.D., Martin J.L. A critical role for system A amino acid transport in the regulation of dendritic development by brain-derived neurotrophic factor (BDNF). J. Biol. Chem. 2007; 282(8): 5152–9. https://doi.org/10.1074/jbc.M608548200
- Echeverria D., Woods J.S., Heyer N.J., Rohlman D.S., Farin F.M., Bittner A.C., et al. Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function. Neurotoxicol. Teratol. 2005; 27(6): 781–96. https://doi.org/10.1016/j.ntt.2005.08.001
- Sudakov K.V., Umryukhin P.E. Systemic Basics of Emotional Stress [Sistemnye osnovy emotsional’nogo stressa]. Moscow: GEOTAR-Media; 2010. (in Russian)
- Kudaeva I.V., Masnavieva L.B., Popkova O.V., D’yakovich O.A. Neurochemical parameters change in individuals exposed to mercury vapors. Meditsina truda i promyshlennaya ekologiya. 2015; (4): 11–5. (in Russian)
- Bar-Or D., Thomas G.W., Rael L.T., Lau E.P., Winkler J.V. Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening. Biochem. Biophys. Res. Commun. 2001; 282(1): 356–60. https://doi.org/10.1006/bbrc.2001.4533
- Gomazkov O.A. Neurotrophic Regulation and Brain Stem Cells [Neyrotroficheskaya regulyatsiya i stvolovye kletki mozga]. Moscow: IKAR; 2006. (in Russian)
- Lang U.E., Bajbouj M., Gallinat J., Hellweg R. Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation. Psychopharmacology (Berl). 2006; 187(1): 56–9. https://doi.org/10.1007/s00213-006-0399-y
- Heyer N.J., Echeverria D., Farin F.M., Woods J.S. The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. J. Toxicol. Environ. Health A. 2008; 71(19): 1318–26. https://doi.org/10.1080/15287390802240850
- Arvanian V.L., Horner P.J., Gage F.H., Mendell L.M. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J. Neurosci. 2003; 23(25): 8706–12. https://doi.org/10.1523/JNEUROSCI.23-25-08706.2003
- Rusanova D.V., Lakhman O.L. Assessment of transferring ways of peripheral nerves in patients with chronic mercury intoxication. Meditsina truda i promyshlennaya ekologiya. 2008; (8): 17–22. (in Russian)
- Tzeng S.F., Huang H.Y. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. J. Cell Biochem. 2003; 2(90): 227–33. https://doi.org/10.1002/jcb.10658
- Masnavieva L.B., Budarina L.A., Kudaeva I.V. Indices of antioxidant protection and lipid peroxidation in persons with neurointoxication in long-term period after exposure. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk. 2010; (4): 115–8. (in Russian)
- Hudgins S.N., Levison S.W. Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro. Exp. Neurol. 1998; 150(2): 171–82. https://doi.org/10.1006/exnr.1997.6735
- Yokoyama H., Uchida H., Kuroiwa H., Kasahara J., Araki T. Role of glial cells in neurotoxin-induced animal models of Parkinson’s disease. Neurol. Sci. 2011; 32(1): 1–7. https://doi.org/10.1007/s10072-010-0424-0
- Katamanova E.V., Kudaeva I.V., Lakhman O.L., Masnavieva L.B., Popkova O.V. A method for differential diagnosis of initial manifestations and the first degree of chronic mercury intoxication. Patent RF № 2513299 C1; 2014. (in Russian)
- Kudaeva I.V., D’yakovich O.A., Katamanova E.V., Popkova O.V., Masnavieva L.B. Clinical and biochemical characteristics of disorders of the nervous system and the risks of common pathological syndromes in mercury production workers. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2015; 94(7): 68–72. (in Russian)
- Preobrazhenskaya I.S. Mild and moderate cognitive impairments: clinical manifestations, etiology, pathogenesis, treatment approaches. Nevrologiya, neyropsikhiatriya, psikhosomatika. 2013; 5(1): 59–63. https://doi.org/10.14412/2074-2711-2013-2401 (in Russian)
- Lieberman J.A., Drake R.E., Sederer L.I., Belger A., Keefe R., Perkins D., et al. Science and recovery in schizophrenia. Psychiatr. Serv. 2008; 59(5): 487–96. https://doi.org/10.1176/ps.2008.59.5.487
- Levin Ya.I. Neurochemical medicine. Part 1. Cerebral dopaminergic systems. Sovremennaya terapiya psikhicheskikh rasstroystv. 2008; (1): 4–8. (in Russian)
- Brindley R.L., Bauer M.B., Blakely R.D., Currie K.P.M. Serotonin and serotonin transporters in the adrenal medulla: a potential hub for modulation of the sympathetic stress response. ACS Chem. Neurosci. 2017; 8(5): 943–54. https://doi.org/10.1021/acschemneuro.7b00026
- Gershon M.D. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans. Am. Clin. Climatol. Assoc. 2012; 123: 268–80.
- Timotijević I., Stanković Ž., Todorović M., Marković S.Z., Kastratović D.A. Serotonergic organization of the central nervous system. Psychiatr. Danub. 2012; 24(S3): 326–30.
- Grigorova O.V., Akhapkin R.V., Aleksandrovskiy Yu.A. Modern concepts of pathogenetic therapy of anxiety disorders. Zhurnal nevrologii i psikhiatrii im. C.C. Korsakova. 2019; 119(10): 111–20. https://doi.org/10.17116/jnevro2019119101111 (in Russian)
- Grazhdan I.K., Kopylov F.Yu., Aksenova M.G., Barskiy V.I., Kirillov A.V. Pathogenetic relationship between personality traits and mental derangement with coronary heart disease. Kardiologiya i serdechno-sosudistaya khirurgiya. 2015; 8(2): 8–20. https://doi.org/10.17116/kardio2015828-20 (in Russian)
- Côté F., Fligny C., Fromes Y., Mallet J., Vodjdani G. Recent advances in understanding serotonin regulation of cardiovascular function. Trends Mol. Med. 2004; 10(5): 232–8. https://doi.org/10.1016/j.molmed.2004.03.007
- Sosedova L.M., Kudaeva I.V., Titov E.A., Yakimova N.L., Masnavieva L.B., Katamanova E.V. Morphologic and neurochemical effects in long-term period of mercurial intoxication (experimental data). Meditsina truda i promyshlennaya ekologiya. 2009; (1): 37–42. (in Russian)
Supplementary files
