Rare Forms of Vitamin D-Binding Protein (DBP): an Analytical Literature Review

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Abstract

The article presents an analysis of the literature data on the structure and functions of vitamin D-binding protein (DBP), which is controlled by a single gene with three clearly defined alleles Gc1-F, Gc1-S, and Gc2. The article presents information on various structural and functional variants of DBP, which are determined genetically and can undergo post-translational modification by glycosylation. One of the derivatives of DBP is its partially deglycosylated form, which exhibits properties of a specific activator of macrophages and is designated as the GcMAF factor. The article pays special attention to rare forms of DBP, detected by the isofocusing method. An assumption is made about the nature of rare forms of DBP and the mechanism of occurrence of changes underlying the appearance of these forms.

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About the authors

E. V. Levites

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: levites@bionet.nsc.ru
Russian Federation, Novosibirsk, 630090

S. S. Kirikovich

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: levites@bionet.nsc.ru
Russian Federation, Novosibirsk, 630090

A. S. Proskurina

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: levites@bionet.nsc.ru
Russian Federation, Novosibirsk, 630090

N. A. Ivanov

Novosibirsk State University

Email: levites@bionet.nsc.ru
Russian Federation, Novosibirsk, 630090

Yu. S. Snegireva

ITMO National Research University

Email: levites@bionet.nsc.ru
Russian Federation, Saint Petersburg, 191002

S. S. Bogachev

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: labmolbiol@mail.ru
Russian Federation, Novosibirsk, 630090

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2. Fig. 1. Western blot analysis of DBP samples obtained by chromatography through Sepharose (with 25-OH vitamin D3) (1) and actin (2) columns [14]. M - molecular marker (Thermo Fisher Scientific Inc., USA).

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