Genomic Analysis of Fur Color of Sable (Martes zibellina L.), Search for Mutations that Determine the Absence of Pigmentation – Albino
- Authors: Filimonov P.A.1, Manakhov A.D.1,2,3, Mitina M.I.2, Onokhov A.A.1, Chernova I.Е.4, Maksimova L.V.4, Kashtanov S.N.1, Rogaev E.I.2,3,5
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Affiliations:
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Center for Genetics and Life Science, Sirius University of Science and Technology
- Center for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University
- AO «Russian Sable» Moscow oblast, Pregion
- Department of Psychiatry, University of Massachusetts Medical School
- Issue: Vol 60, No 11 (2024)
- Pages: 112-117
- Section: КРАТКИЕ СООБЩЕНИЯ
- URL: https://rjpbr.com/0016-6758/article/view/667171
- DOI: https://doi.org/10.31857/S0016675824110107
- EDN: https://elibrary.ru/waxtha
- ID: 667171
Cite item
Abstract
In the domesticated sable population, after almost 100 years of selection, individuals with colored fur began to be recorded, so, in the offspring of a pair of sables with black fur, a pastel-colored puppy was born. A single-nucleotide insertion was identified in the TYRP1 gene, which determines this sable fur color; the type of inheritance is recessive. In 2022, in this population, representatives of two sable lines gave birth to puppies with white fur at the same time. In most mammalian species, albinism is caused by mutations in the TYR gene, which encodes the enzyme tyrosinase. In the present study, the sable TYR gene was investigated as a functional candidate gene for albinism. Analysis of the nucleotide sequences coding for the TYR gene region and splicing sites did not reveal differences in white sables from standard- colored sables, suggesting that the phenotype under study is due to genetic variants in other genes.
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About the authors
P. A. Filimonov
Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: snkashtanov@mail.ru
Russian Federation, Moscow, 119991
A. D. Manakhov
Vavilov Institute of General Genetics, Russian Academy of Sciences; Center for Genetics and Life Science, Sirius University of Science and Technology; Center for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University
Email: snkashtanov@mail.ru
Russian Federation, Moscow, 119991; Sochi, 354340; Moscow, 119192
M. I. Mitina
Center for Genetics and Life Science, Sirius University of Science and Technology
Email: snkashtanov@mail.ru
Russian Federation, Sochi, 354340
A. A. Onokhov
Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: snkashtanov@mail.ru
Russian Federation, Moscow, 119991
I. Е. Chernova
AO «Russian Sable» Moscow oblast, Pregion
Email: snkashtanov@mail.ru
Russian Federation, pos. Zverosovkhoz, 141214
L. V. Maksimova
AO «Russian Sable» Moscow oblast, Pregion
Email: snkashtanov@mail.ru
Russian Federation, pos. Zverosovkhoz, 141214
S. N. Kashtanov
Vavilov Institute of General Genetics, Russian Academy of Sciences
Author for correspondence.
Email: snkashtanov@mail.ru
Russian Federation, Moscow, 119991
E. I. Rogaev
Center for Genetics and Life Science, Sirius University of Science and Technology; Center for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University; Department of Psychiatry, University of Massachusetts Medical School
Email: snkashtanov@mail.ru
Russian Federation, Sochi, 354340; Moscow, 119192; Worcester, MA 01604, USA
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