UV-induced fluorescence spectroscopy of skin in vivo in Parkinson’s disease

V. V. Salmin; Салмин В. В.; V. B. Loschenov; Лощенов В. Б.; A. B. Ochirova; Очирова А. Б.; N. P. Bainaev-Mangilev; Байнаев-Мангилев Н. П.; M. N. Andreev; Андреев М. Н.; E. Yu. Fedotova; Федотова Е. Ю.; A. B. Salmina; Салмина А. Б.; S. N. Illarioshkin; Иллариошкин С. Н.

doi:10.31857/S2686738925010044

UV-induced fluorescence spectroscopy of skin in vivo in Parkinson’s disease

作者: Salmin V.V.¹^,2^,3, Loschenov V.B.³^,4, Ochirova A.B.³, Bainaev-Mangilev N.P.³, Andreev M.N.⁵, Fedotova E.Y.⁵, Salmina A.B.⁵, Illarioshkin S.N.⁵
隶属关系:
1. Moscow Institute of Physics and Technology
2. Bauman Moscow State Technical University
3. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
4. Prokhorov General Physics Institute of the Russian Academy of Sciences
5. Research Center of Neurology
期: 卷 520, 编号 1 (2025)
页面: 19-25
栏目: Articles
URL: https://rjpbr.com/2686-7389/article/view/682019
DOI: https://doi.org/10.31857/S2686738925010044
EDN: https://elibrary.ru/tdfoqg
ID: 682019

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详细

We found characteristic patterns of UV-induced skin autofluorescence in patients with Parkinson’s disease associated with the development of dysmetabolic alterations like non-enzymatic protein glycation and an increase in the extracellular matrix stiffness, impaired metabolism of tissue fluorophores, mitochondrial dysfunction, and accumulation of aberrant proteins. For the first time, we demonstrate the key differences in the skin autofluorescence spectra in Parkinson’s disease that allow distinguishing them from those obtained in healthy persons or in individuals without signs of chronic neurodegeneration: skin fluorescence is lower in relation to the reflected signal when it is excited by UV light with a wavelength of 375 nm in patients with Parkinson’s disease.

关键词

Parkinson disease, alpha-Synuclein, Advanced Glycation Endproducts, Fluorescence Spectroscopy, Skin

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Academician of thе RAS

俄罗斯联邦, Moscow

参考

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