Pharmacological Modulation of Cognitivr Test Solution in Mice of Two Genotypes

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Abstract

Mice of two strains selected for successful solution of “object permanence” test and for lack of such solution demonstrated the differential reaction to injections of two drugs. The injections of atomoxetine. which blocks the noradrenaline reuptake, and of ‘non-benzodiazepine” anxiolytic afobazol was different. The success of solutions increased in mice selected for this test “non-solution”: and decreased or was inefficient in mice, selected for successful solution of object permanence cognitive test.

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About the authors

O. V. Perepelkina

Lomonossov Moscow State University

Author for correspondence.
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow

I. I. Poletaeva

Lomonossov Moscow State University

Email: ingapoletaeva@mail.ru
Russian Federation, Moscow

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2. Fig. 1. Percentages (%, ordinate axis) of successful solutions in the shelter entrance test with the hole masked by a stopper (total for two trials of this test). Indicators of the “+” line – pair of bars on the left, “–” line – pair of bars on the right. Black bars – effect of Afobazole (A) and Atomoxetine (B), gray – control. * *** – significant differences at p < 0.05 and p < 0.001 (Fisher’s exact test, evaluation of alternative proportion differences).

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