Molecular mechanisms of heat shock protein 27 under physical exertion and its role in cardiovascular disease prevention



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Abstract

Cardiovascular diseases (CVDs) pose a serious threat to public health in the Russian Federation and remain the leading cause of mortality. In 2016, the economic burden of CVDs amounted to 2.7 trillion rubles, representing 3.2% of the country’s gross domestic product. Major risk factors for CVDs, such as physical inactivity, smoking, alcohol consumption, unhealthy diet, and obesity, are directly associated with deterioration of cardiovascular system condition. Circulating heat shock protein 27 (HSP27) exhibits numerous beneficial properties, including involvement in inflammatory regulation, antioxidant, anti-apoptotic, and anti-atherogenic processes. Acting as a signaling molecule in the blood, it helps the body cope with various types of stress. Studies show that HSP27 levels decline with age and during menopause, potentially contributing to the development of atherosclerosis, which is a key factor in the development of many CVDs. Physical exercise exerts a positive influence on the body by increasing plasma HSP27 levels. This elevation may have an immunomodulatory effect on various immune cells, including monocytes. Through this mechanism, physical activity supports the body in managing inflammation and reducing the risk of CVDs. Thus, understanding the role of HSP27 in the context of physical exertion offers new opportunities for the prevention and treatment of CVDs. Further research may lead to innovative therapeutic strategies aimed at enhancing HSP27 levels and lowering the risk of atherosclerosis and other CVDs.

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About the authors

Aleksandr A. Rachkov

Rostov State Medical University

Author for correspondence.
Email: motoredj2@rambler.ru
ORCID iD: 0009-0002-8654-0229
Russian Federation, 29 Nakhichevan aly, Rostov-on-Don, 344022

Alina S. Oleynikova

Rostov State Medical University

Email: a_vinyukova@list.ru
ORCID iD: 0009-0000-4740-0755
Russian Federation, 29 Nakhichevan aly, Rostov-on-Don, 344022

Alena I. Borolisova

Rostov State Medical University

Email: alena-dits@mail.ru
ORCID iD: 0009-0003-2145-3041
Russian Federation, 29 Nakhichevan aly, Rostov-on-Don, 344022

Ikbol I. Mirzosharipov

Bashkir State Medical University

Email: ikbol.ikromi@bk.ru
ORCID iD: 0009-0000-7655-661X
Russian Federation, Ufa

Ruslan R. Makhyanov

Bashkir State Medical University

Email: ruslanmakhyanov0608@gmail.com
ORCID iD: 0009-0001-0437-1744
Russian Federation, Ufa

Sofia A. Kadochnikova

Kazan Federal University

Email: skadochnikovaa@mail.ru
ORCID iD: 0009-0002-1901-830X
Russian Federation, Kazan

Liliya A. Khairullina

City Polyclinic N. 21

Email: lily_2205khai@mail.ru
ORCID iD: 0009-0009-5342-269X
Russian Federation, Kazan

Khabibat B. Abutalimova

Dagestan State Medical University

Email: habibat408@gmail.com
ORCID iD: 0009-0001-3702-3965
Russian Federation, Makhachkala

Ruslan O. Zimin

Krasnoyarsk State Medical University

Email: Zimin.ruslan99@mail.ru
ORCID iD: 0009-0003-0792-2307
Russian Federation, Krasnoyarsk

Nazira F. Merdalieva

Russian University of Medicine

Email: merdalieva6@gmail.com
ORCID iD: 0009-0006-5411-0813
Russian Federation, Moscow

Kirill B. Pokidov

Voronezh State Medical University

Email: pokidov.kiril@yandex.ru
ORCID iD: 0009-0005-0438-7569
Russian Federation, Voronezh

Diana A. Nelyubina

Voronezh State Medical University

Email: di709@yandex.ru
ORCID iD: 0000-0002-6279-9300
Russian Federation, Voronezh

Darya O. Boiko

Rostov State Medical University

Email: cuttheworld57@gmail.com
ORCID iD: 0009-0006-9493-1763
Russian Federation, 29 Nakhichevan aly, Rostov-on-Don, 344022

Sofya A. Kharchenko

Rostov State Medical University

Email: Sofiaivanova79@mail.ru
ORCID iD: 0000-0001-7635-7418
Russian Federation, 29 Nakhichevan aly, Rostov-on-Don, 344022

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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