Molecular mechanisms of action of heat shock protein 27 under conditions of physical exertion and its role in the prevention of cardiovascular diseases



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Abstract

Cardiovascular diseases (CVD) pose a serious threat to public health in the Russian Federation, being the leading cause of death. The economic impact of CVD in 2016 amounted to a staggering 2.7 trillion rubles, which corresponds to 3.2% of the country's GDP. Risk factors for CVD, such as sedentary lifestyle, smoking, alcohol consumption, unhealthy eating habits, and obesity, directly contribute to deteriorating heart and vascular health. The circulating heat shock protein (HSP)27 plays a key role in inflammatory, antioxidant, anti-apoptotic, and anti-atherogenic processes. It serves as a signaling molecule in the blood, helping the body cope with various types of stress. Studies show that the level of HSP27 decreases with age and during menopause, which may contribute to the development of atherosclerosis. Atherosclerosis, in turn, is a major factor in many cardiovascular diseases. Physical exercise has beneficial effects on the body, promoting an increase in the level of HSP27 in the blood plasma. This increase can have immunomodulatory effects on various cells of the immune system, including monocytes. Through this mechanism, physical activity helps the body fight inflammation and reduce the risk of cardiovascular diseases. Therefore, understanding the role of HSP27 in the context of physical activity opens up new prospects for the prevention and treatment of CVD. Further research in this area could lead to the development of innovative therapeutic strategies aimed at increasing the level of HSP27 and reducing the risk of atherosclerosis and other cardiovascular diseases.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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