Application of combined enzyme therapy for complications of lip contouring in cosmetology

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Purpose: to study the effectiveness of a combined method that includes a course of magnetolaserophoresis of longidase and diadinamophoresis of collalizin 1000 KE (collagenase units) in correcting complications of lip contouring that occurred when a large volume of filler or surface injection of a drug based on stabilized hyaluronic acid into the skin.

Material and methods. We observed 31 women aged 25 to 32 years with complications after the introduction of a filler based on stabilized hyaluronic acid with localization in the lip area. Were allocated to three groups who received a course of magnetolaserotherapy of longidaza, the rate of diadynamophoresis of collalizin, or a combination.

Results. The use of a combined course of longidase magnetolaserophoresis with collazine diadinamophoresis has a significant clinical effect, reducing edema, gel contouring phenomena and stabilizing the psychoemotional state of patients. In addition, the treatment complex significantly accelerates the biodegradation of the filler and has a restructuring effect on the lip tissue, gives a pronounced effect of reducing the thickness of the dermis and increasing the density coefficient of the dermis, which is probably due to a decrease in intra-dermal edema that occurs as a reaction to a surface-injected filler.

Conclusions. Combined use of magnetolaserotherapy of longidaza and diadynamophoresis of collalizin to the lip when complications in the form of a surface of introduction of the filler or injecting too much of the drug based on stabilized hyaluronic acid is a highly effective method of treatment, which is confirmed by relief of clinical symptoms and improvement in quality of life of patients.

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About the authors

Irina P. Aksenenko

Aesthetic Medicine Clinic

Author for correspondence.
ORCID iD: 0000-0003-3602-594X
SPIN-code: 8172-4573

Russian Federation, Mosccow


  1. The American Society for Aesthetic Plastic Surgery. Cosmetic surgery national data bank statistics. Available from: http// org/sites/default/files/ASAPS-2011-Stats.pdf
  2. Karpova EI, Gubanova EI, Spasova VG, Chaykovskaya EA. Adverse events and complications the injection lip. Injection contour plastic. Moscow; 2015. P. 412–423. (In Russ).
  3. Mingazova LR, Karpova EI, Orlova OR. Neuropathic disorders in the face area after contour injection sculpture. Injection contour plastic. Moscow; 2015. P. 372–378. (In Russ).
  4. Ranneva EA, Depre F. Hyaluronidase in aesthetic medicine: theoretical background and practical application experience. Injection contour plastic. Moscow; 2015. P. 429–435. (In Russ).
  5. Talybova AP, Kruglova LS, Stenko AG. Ultraphonophoresis of enzyme drugs in treatment of postacne scars. Russian Journal of the Physial Therapy, Balneotherapy and Rehabilitation. 2017;16(5):254–256. (In Russ). doi: 10.18821/1681-3456-2017-16-5-254-256
  6. Paramonov BA. Collagenolytic enzymes. Part 1. Unresolved and controversial issues of theory and practice [Kollagenoliticheskie fermenty. Chast' 1. Nereshennye i spornye voprosy teorii i praktiki]. Cosmetics and Medicine. 2016;(1):32–41.
  7. Encyclopedia of Medicines 2017. Radar. Issue 25. Ed. by G.L. Vyshkovsky. Moscow: Vedanta; 2016. 1288 p.
  8. Trunin EM, Kandalova IG, Now IV, et al. Use Kollalizin for the treatment of hypertrophic scars after operations on the thyroid gland [Ispol'zovanie Kollalizina dlya lecheniya gipertroficheskikh rubtsov posle operatsii na shchitovidnoi zheleze]. Poliklinika. 2009;(1):120–121.
  9. Perestavina SK, Vasin AS. Application of fermencol gel phonophoresis in the treatment of post-acne scars [Primenenie fonoforeza gelya fermenkol v lechenii rubtsov postakne]. Dermatology in Russia. 2017;(S1):75–76.



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