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Effectiveness of pharmacopuncture by “alloplant” biomaterial in complex therapy of knee joint osteoarthritis
- Authors: Urazbakhtin R.K.1, Kildebekova R.N.2, Gilmutdinova L.T.2, Kaybyshev V.T.2, Mirkhaydarov R.S.1, Allayarova R.A.2
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Affiliations:
- Scientific Research and Health-Improving Center “Health and Longevity”
- Bashkir State Medical Univer
- Issue: Vol 19, No 1 (2020)
- Pages: 45-49
- Section: Original studies
- URL: https://rjpbr.com/1681-3456/article/view/41841
- DOI: https://doi.org/10.17816/1681-3456-2020-19-1-7
- ID: 41841
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Abstract
Background. Osteoarthritis is characterized by a decrease in the quality of life, which is currently considered as the main measure of well-being of an individual and a criterion for the effectiveness of treatment and rehabilitation measures. Modern research emphasizes the need for an integrated approach to the treatment of osteoarthritis, which should include pharmacological and non-drug methods of treatment.
Aim. The purpose of the study was to evaluate the effectiveness of pharmacopuncture administration of Alloplant biomaterial by patients with osteoarthritis of the knee joint from the standpoint of influencing the immunological mechanisms of the disease.
Methods. The randomization methodology was divided into 3 groups, comparable in terms of clinical and functional characteristics. Group I patients (n = 39) have standard basic drug therapy according to the federal clinical guidelines “Osteoarthritis” approved by the Association of Rheumatologists of Russia (2013), with additions from 2016; in patients of group II (n = 39), in addition to drug therapy, dispersed Alloplant biomaterial was used according to the original method; group III patients (n = 39) against the background of basic drug therapy are additionally prescribed a combination of dispersed Alloplant biomaterial at biologically active points and magnetic therapy with a pulsed magnetic field.
Results. Against the background of the treatment of patients with osteoarthritis using pharmacopuncture with Alloplant biomaterial and magnetotherapy, there was a positive dynamics in clinical data with a significant decrease in pain intensity when walking and at rest, stiffness, with the restoration of immune status parameters and an improvement in the quality of life in the field of physical and psychological health . A more pronounced and lasting positive dynamics was observed in patients of group III against the background of the combined effects of pharmacopuncture with Alloplant biomaterial and magnetotherapy.
Conclusion. The Alloplant biomaterial has a positive effect in the treatment of patients with stage I–II osteoarthritis according to the Kellgren–Lawrens classification. The similarity of the mechanism of action with drugs with a structurally modifying effect on cartilage allows us to recommend pharmacopuncture with Alloplant biomaterial for widespread use in the treatment of osteoarthritis.
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About the authors
Ruslan K. Urazbakhtin
Scientific Research and Health-Improving Center “Health and Longevity”
Author for correspondence.
Email: kailas4@bk.ru
Russian Federation, Ufa
Raushaniya N. Kildebekova
Bashkir State Medical Univer
Email: kildebekova49@mail.ru
Russian Federation, Ufa
Lira T. Gilmutdinova
Bashkir State Medical Univer
Email: gilmutdinova23@mail.ru
Russian Federation, Ufa
Vadim T. Kaybyshev
Bashkir State Medical Univer
Email: kaf.mpz-mk@yandex.ru
Russian Federation, Ufa
Ravil Sh. Mirkhaydarov
Scientific Research and Health-Improving Center “Health and Longevity”
Email: kailas4@bk.ru
Russian Federation, Ufa
Raushaniya A. Allayarova
Bashkir State Medical Univer
Email: raushania.allayarova@yandex.ru
Russian Federation, Ufa
References
- Luchikhina LV, Mendel OI, Mendel V, Golukhov GN. Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease. Sovremennaia revmatologiia. 2017;11(1):4–11. (In Russ). doi: 10.14412/1996-7012-2017-1-4-11.
- Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010;18(1):24–33. doi: 10.1016/j.joca.2009.08.010.
- Cuper C, Dennison E. Epidemiology of osteoarthritis. Medicographia. 2013;35:145–151.
- Alekseeva LI, Taskina EA, Kashevarova NG. Osteoarthritis: epidemiology, classification, risk factors, and progression, clinical presentation, diagnosis, and treatment. Sovremennaia revmatologiia. 2019;13(2):9–21. (In Russ). doi: 10.14412/1996-7012-2019-2-9-21.
- Gil'mutdinova LT, Khaibullina ZR, Sakhabutdinova AR, Gil'mutdinov AR. Reabilitatsiia bol'nykh s povrezhdeniiami pozvonochnika. Ufa: Gilem, Bashk.entsikl.; 2013. 240 р. (In Russ.)
- Nguyen U, Zhang Y, Zhu Y, et al. Increasing prevalence of knee pain and symptomatic knee osteoarthritis survey and cohort data. Ann Intern Vied. 2011;155(11):725–732. doi: 10.7326/0003-4819-155- 11-201112060-00004.
- Scanzello CR. Role of low inflammation in osteoarthritis. Curr Opin Rheumatol. 2017;29(1):79–85. doi: 10.1097/ BOR.0000000000000353.
- Wasserman LI, Trifonova EA, Fedorova VL. Personal disease picture in quality of life structure in individuals with physical illnesses. Sibirskii psihologicheskii zhurnal. 2008;(27):67–71. (In Russ).
- Bruyere О, Cooper С, Pelletier JP, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(4 Suppl):3–11. doi: 10.1016/j.semarthrit.2015.11.010.
- Cho SK, Kim H, Park HR, et al. Nonsteroidal anti-inflammatory drugs-sparing effect of symptomatic slow-acting drugs for osteoarthritis in knee osteoarthritis patients. J Rheum Dis. 2019;26(3):179–185. doi: 10.4078/jrd.2019.26.3.179.
- Hochberg MC, Martel-Pelletier J, Monfort J, et al. On behalf of the MOVES Investigation Group. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomized, doble-blind, non-inferioriti trial versus celecoxib. Ann Rheum Dis. 2016;75(1):37–44. doi: 10.1136/annrheumdis-2014-206792.
- Tsurko VV, Zamyatina EA, Bagirova GG. Osteoarthritis: management of patients and compliance to treatment. Medicinskii sovet. 2017;(20):134–137. (In Russ). doi: 10.21518/2079-701X-2017-20-134-137.
- Muldashev ER. “Alloplant” technology as the innovational model of regenerative surgery. Prakticheskaia medicina. 2019;17(1):12–16. (In Russ).
- Ten VP, Muldashev ER, Kim LS, et al. Akupunkturnaia terapiia biomaterialom «Alloplant». Sovremennye naukoemkie tekhnologii. 2005;(8):104–105.
- Patent RUS № 2238076. Muldashev ER, Mirkhaidarov RSh, Urazbakhtin RK, et al. Sposob lecheniia i profilaktiki zabolevanii vozdeistviem na biologicheski aktivnye tochki i zony. (In Russ).
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