To Explore the Mechanism of Maiwei Dihuang Decoction in the Treatment of Non-small Cell Lung Cancer based on Network Pharmacology Combined with LC-MS
- Authors: Jiang T.1, Lu Y.1, Yang W.2, Xu J.1, Zhu M.1, Huang Y.1, Bao F.1, Zheng S.1, Li Y.1
-
Affiliations:
- Department of Pharmacy, Navy Anqing Hospital
- Department of Pharmacy,, Anqing First People's Hospital of Anhui Medical University
- Issue: Vol 20, No 5 (2024)
- Pages: 590-597
- Section: Chemistry
- URL: https://rjpbr.com/1573-4099/article/view/644168
- DOI: https://doi.org/10.2174/1573409920666230823161355
- ID: 644168
Cite item
Full Text
Abstract
Objective:To explore the mechanism of Maiwei Dihuang decoction in the treatment of non-small cell lung cancer (NSCLC) by using network pharmacology and LC-MS technology.
Methods:The effective components in Maiwei Dihuang decoction were detected by liquid chromatography- mass spectrometry (LC-MS). Use the SuperPred database to collect the relevant targets of the active ingredients of Mai Wei Di Tang, and then collect the relevant targets of nonsmall cell lung cancer from GeneCards, DisgenNET and OMIM databases. On this basis, PPI network construction, GO enrichment analysis and KEGG pathway annotation analysis were carried out for target sites. Finally, AutoDock Vina is used for molecular docking.
Results:We further screened 16 effective Chinese herbal compounds through LC-MS combined with ADME level. On this basis, we obtained 77 core targets through protein interaction network analysis. Through GO, KEGG analysis and molecular docking results, we finally screened out the potential targets of Maiwei Dihuang Decoction for NSCLC: TP53, STAT3, MAPK3.
Conclusion:Maiwei Dihuang decoction may play a role in the treatment of NSCLC by coregulating TP53/STAT3/MAPK3 signal pathway.
About the authors
Tao Jiang
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Yang Lu
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Wanzhi Yang
Department of Pharmacy,, Anqing First People's Hospital of Anhui Medical University
Email: info@benthamscience.net
Jinhong Xu
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Mingxing Zhu
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Yong Huang
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Fang Bao
Department of Pharmacy, Navy Anqing Hospital
Email: info@benthamscience.net
Shengqi Zheng
Department of Pharmacy, Navy Anqing Hospital
Author for correspondence.
Email: info@benthamscience.net
Yongxia Li
Department of Pharmacy, Navy Anqing Hospital
Author for correspondence.
Email: info@benthamscience.net
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