Exploring the Molecular Mechanism of HongTeng Decoction against Inflammation based on Network Analysis and Experiments Validation


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Abstract

Background:HongTeng Decoction (HTD) is a traditional Chinese medicine that is widely used to treat bacterial infections and chronic inflammation. However, its pharmacological mechanism is not clear. Here, network pharmacology and experimental verification were applied to investigate the drug targets and potential mechanisms of HTD in inflammation treatment.

Methods:The active ingredients of HTD were collected from the multi-source databases and clarified by Q Exactive Orbitrap analysis in the treatment of inflammation. Then, molecular docking technology was used to explore the binding ability of key active ingredients and targets in HTD. In vitro experiments, the inflammatory factors and MAPK signaling pathways are detected to verify the anti-inflammatory effect of HTD on the RAW264.7 cells. Finally, the anti-inflammatory effect of HTD was evaluated in LPS induced mice model.

Result:A total of 236 active compounds and 492 targets of HTD were obtained through database screening, and 954 potential targets of inflammation were identified. Finally, 164 possible targets of HTD acting on inflammation were obtained. The PPI analysis and KEGG enrichment analyses showed that the targets of HTD in inflammation were mostly related to the MAPK signaling pathway, the IL-17 signaling pathway, and the TNF signaling pathway. By integrating the results of the network analysis, the core targets of HTD in inflammation mainly include MAPK3, TNF, MMP9, IL6, EGFR, and NFKBIA. The molecular docking results indicated solid binding activity between MAPK3-naringenin and MAPK3-paeonol. It has been shown that HTD could inhibit the levels of inflammatory factors, IL6 and TNF-α, as well as the splenic index in the LPS-stimulated mice. Moreover, HTD could regulate protein expression levels of p-JNK1/2, and p-ERK1/2, which reflects the inhibitory effect of HTD on the MAPKS signaling pathway.

Conclusion:Our study is expected to provide the pharmacological mechanisms by which HTD may be a promising anti-inflammatory drug for future clinical trials.

About the authors

Yuanyuan Yang

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Chongwen Bi

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Bin Li

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Yun Li

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Yin Song

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Minghui Zhang

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Longxi Peng

, Tianjin Medical University, General Hospital

Email: info@benthamscience.net

Dongmei Fan

Tianjin Key Laboratory of Blood Disease Cell Therapy, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital

Author for correspondence.
Email: info@benthamscience.net

Rong Duan

, Tianjin Medical University, Tianjin Medical University General Hospital

Author for correspondence.
Email: info@benthamscience.net

Zhengxiang Li

, Tianjin Medical University, General Hospital

Author for correspondence.
Email: info@benthamscience.net

References

  1. Dona, I.; Salas, M.; Perkins, J.; Barrionuevo, E.; Gaeta, F.; Cornejo-Garcia, J.; Campo, P.; Torres, M. Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs. Curr. Pharm. Des., 2017, 22(45), 6784-6802. doi: 10.2174/1381612822666160928142814 PMID: 27779082
  2. Bindu, S.; Mazumder, S.; Bandyopadhyay, U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem. Pharmacol., 2020, 180114147. doi: 10.1016/j.bcp.2020.114147 PMID: 32653589
  3. Zhang, Q.; Li, X.; Li, J. Mechanism of anti-inflammatory and antibacterial effects of qingxiaowuwei decoction based on network pharmacology, molecular docking and in vitro experiments. Front. Pharmacol., 2021, 12, 1-19.
  4. Furman, D.; Campisi, J.; Verdin, E.; Carrera-Bastos, P.; Targ, S.; Franceschi, C.; Ferrucci, L.; Gilroy, D.W.; Fasano, A.; Miller, G.W.; Miller, A.H.; Mantovani, A.; Weyand, C.M.; Barzilai, N.; Goronzy, J.J.; Rando, T.A.; Effros, R.B.; Lucia, A.; Kleinstreuer, N.; Slavich, G.M. Chronic inflammation in the etiology of disease across the life span. Nat. Med., 2019, 25(12), 1822-1832. doi: 10.1038/s41591-019-0675-0 PMID: 31806905
  5. Stark, K.; Massberg, S. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat. Rev. Cardiol., 2021, 18(9), 666-682. doi: 10.1038/s41569-021-00552-1 PMID: 33958774
  6. Roth, G.A.; Abate, D.; Abate, K.H.; Abay, S.M.; Abbafati, C.; Abbasi, N.; Abbastabar, H.; Abd-Allah, F.; Abdela, J.; Abdelalim, A.; Abdollahpour, I.; Abdulkader, R.S.; Abebe, H.T.; Abebe, M.; Abebe, Z.; Abejie, A.N.; Abera, S.F.; Abil, O.Z.; Abraha, H.N.; Abrham, A.R.; Abu-Raddad, L.J.; Accrombessi, M.M.K.; Acharya, D.; Adamu, A.A.; Adebayo, O.M.; Adedoyin, R.A.; Adekanmbi, V.; Adetokunboh, O.O.; Adhena, B.M.; Adib, M.G.; Admasie, A.; Afshin, A.; Agarwal, G.; Agesa, K.M.; Agrawal, A.; Agrawal, S.; Ahmadi, A.; Ahmadi, M.; Ahmed, M.B.; Ahmed, S.; Aichour, A.N.; Aichour, I.; Aichour, M.T.E.; Akbari, M.E.; Akinyemi, R.O.; Akseer, N.; Al-Aly, Z.; Al-Eyadhy, A.; Al-Raddadi, R.M.; Alahdab, F.; Alam, K.; Alam, T.; Alebel, A.; Alene, K.A.; Alijanzadeh, M.; Alizadeh-Navaei, R.; Aljunid, S.M.; Alkerwi, A.; Alla, F.; Allebeck, P.; Alonso, J.; Altirkawi, K.; Alvis-Guzman, N.; Amare, A.T.; Aminde, L.N.; Amini, E.; Ammar, W.; Amoako, Y.A.; Anber, N.H.; Andrei, C.L.; Androudi, S.; Animut, M.D.; Anjomshoa, M.; Ansari, H.; Ansha, M.G.; Antonio, C.A.T.; Anwari, P.; Aremu, O.; Ärnlöv, J.; Arora, A.; Arora, M.; Artaman, A.; Aryal, K.K.; Asayesh, H.; Asfaw, E.T.; Ataro, Z.; Atique, S.; Atre, S.R.; Ausloos, M.; Avokpaho, E.F.G.A.; Awasthi, A.; Quintanilla, B.P.A.; Ayele, Y.; Ayer, R.; Azzopardi, P.S.; Babazadeh, A.; Bacha, U.; Badali, H.; Badawi, A.; Bali, A.G.; Ballesteros, K.E.; Banach, M.; Banerjee, K.; Bannick, M.S.; Banoub, J.A.M.; Barboza, M.A.; Barker-Collo, S.L.; Bärnighausen, T.W.; Barquera, S.; Barrero, L.H.; Bassat, Q.; Basu, S.; Baune, B.T.; Baynes, H.W.; Bazargan-Hejazi, S.; Bedi, N.; Beghi, E.; Behzadifar, M.; Behzadifar, M.; Béjot, Y.; Bekele, B.B.; Belachew, A.B.; Belay, E.; Belay, Y.A.; Bell, M.L.; Bello, A.K.; Bennett, D.A.; Bensenor, I.M.; Berman, A.E.; Bernabe, E.; Bernstein, R.S.; Bertolacci, G.J.; Beuran, M.; Beyranvand, T.; Bhalla, A.; Bhattarai, S.; Bhaumik, S.; Bhutta, Z.A.; Biadgo, B.; Biehl, M.H.; Bijani, A.; Bikbov, B.; Bilano, V.; Bililign, N.; Bin Sayeed, M.S.; Bisanzio, D.; Biswas, T.; Blacker, B.F.; Basara, B.B.; Borschmann, R.; Bosetti, C.; Bozorgmehr, K.; Brady, O.J.; Brant, L.C.; Brayne, C.; Brazinova, A.; Breitborde, N.J.K.; Brenner, H.; Briant, P.S.; Britton, G.; Brugha, T.; Busse, R.; Butt, Z.A.; Callender, C.S.K.H.; Campos-Nonato, I.R.; Campuzano Rincon, J.C.; Cano, J.; Car, M.; Cárdenas, R.; Carreras, G.; Carrero, J.J.; Carter, A.; Carvalho, F.; Castañeda-Orjuela, C.A.; Castillo Rivas, J.; Castle, C.D.; Castro, C.; Castro, F.; Catalá-López, F.; Cerin, E.; Chaiah, Y.; Chang, J-C.; Charlson, F.J.; Chaturvedi, P.; Chiang, P.P-C.; Chimed-Ochir, O.; Chisumpa, V.H.; Chitheer, A.; Chowdhury, R.; Christensen, H.; Christopher, D.J.; Chung, S-C.; Cicuttini, F.M.; Ciobanu, L.G.; Cirillo, M.; Cohen, A.J.; Cooper, L.T.; Cortesi, P.A.; Cortinovis, M.; Cousin, E.; Cowie, B.C.; Criqui, M.H.; Cromwell, E.A.; Crowe, C.S.; Crump, J.A.; Cunningham, M.; Daba, A.K.; Dadi, A.F.; Dandona, L.; Dandona, R.; Dang, A.K.; Dargan, P.I.; Daryani, A.; Das, S.K.; Gupta, R.D.; Neves, J.D.; Dasa, T.T.; Dash, A.P.; Davis, A.C.; Davis Weaver, N.; Davitoiu, D.V.; Davletov, K.; De La Hoz, F.P.; De Neve, J-W.; Degefa, M.G.; Degenhardt, L.; Degfie, T.T.; Deiparine, S.; Demoz, G.T.; Demtsu, B.B.; Denova-Gutiérrez, E.; Deribe, K.; Dervenis, N.; Des Jarlais, D.C.; Dessie, G.A.; Dey, S.; Dharmaratne, S.D.; Dicker, D.; Dinberu, M.T.; Ding, E.L.; Dirac, M.A.; Djalalinia, S.; Dokova, K.; Doku, D.T.; Donnelly, C.A.; Dorsey, E.R.; Doshi, P.P.; Douwes-Schultz, D.; Doyle, K.E.; Driscoll, T.R.; Dubey, M.; Dubljanin, E.; Duken, E.E.; Duncan, B.B.; Duraes, A.R.; Ebrahimi, H.; Ebrahimpour, S.; Edessa, D.; Edvardsson, D.; Eggen, A.E.; El Bcheraoui, C.; El Sayed Zaki, M.; El-Khatib, Z.; Elkout, H.; Ellingsen, C.L.; Endres, M.; Endries, A.Y.; Er, B.; Erskine, H.E.; Eshrati, B.; Eskandarieh, S.; Esmaeili, R.; Esteghamati, A.; Fakhar, M.; Fakhim, H.; Faramarzi, M.; Fareed, M.; Farhadi, F.; Farinha, C.S.E.; Faro, A.; Farvid, M.S.; Farzadfar, F.; Farzaei, M.H.; Feigin, V.L.; Feigl, A.B.; Fentahun, N.; Fereshtehnejad, S-M.; Fernandes, E.; Fernandes, J.C.; Ferrari, A.J.; Feyissa, G.T.; Filip, I.; Finegold, S.; Fischer, F.; Fitzmaurice, C.; Foigt, N.A.; Foreman, K.J.; Fornari, C.; Frank, T.D.; Fukumoto, T.; Fuller, J.E.; Fullman, N.; Fürst, T.; Furtado, J.M.; Futran, N.D.; Gallus, S.; Garcia-Basteiro, A.L.; Garcia-Gordillo, M.A.; Gardner, W.M.; Gebre, A.K.; Gebrehiwot, T.T.; Gebremedhin, A.T.; Gebremichael, B.; Gebremichael, T.G.; Gelano, T.F.; Geleijnse, J.M.; Genova-Maleras, R.; Geramo, Y.C.D.; Gething, P.W.; Gezae, K.E.; Ghadami, M.R.; Ghadimi, R.; Ghasemi Falavarjani, K.; Ghasemi-Kasman, M.; Ghimire, M.; Gibney, K.B.; Gill, P.S.; Gill, T.K.; Gillum, R.F.; Ginawi, I.A.; Giroud, M.; Giussani, G.; Goenka, S.; Goldberg, E.M.; Goli, S.; Gómez-Dantés, H.; Gona, P.N.; Gopalani, S.V.; Gorman, T.M.; Goto, A.; Goulart, A.C.; Gnedovskaya, E.V.; Grada, A.; Grosso, G.; Gugnani, H.C.; Guimaraes, A.L.S.; Guo, Y.; Gupta, P.C.; Gupta, R.; Gupta, R.; Gupta, T.; Gutiérrez, R.A.; Gyawali, B.; Haagsma, J.A.; Hafezi-Nejad, N.; Hagos, T.B.; Hailegiyorgis, T.T.; Hailu, G.B.; Haj-Mirzaian, A.; Haj-Mirzaian, A.; Hamadeh, R.R.; Hamidi, S.; Handal, A.J.; Hankey, G.J.; Harb, H.L.; Harikrishnan, S.; Haro, J.M.; Hasan, M.; Hassankhani, H.; Hassen, H.Y.; Havmoeller, R.; Hay, R.J.; Hay, S.I.; He, Y.; Hedayatizadeh-Omran, A.; Hegazy, M.I.; Heibati, B.; Heidari, M.; Hendrie, D.; Henok, A.; Henry, N.J.; Herteliu, C.; Heydarpour, F.; Heydarpour, P.; Heydarpour, S.; Hibstu, D.T.; Hoek, H.W.; Hole, M.K.; Homaie Rad, E.; Hoogar, P.; Hosgood, H.D.; Hosseini, S.M.; Hosseinzadeh, M.; Hostiuc, M.; Hostiuc, S.; Hotez, P.J.; Hoy, D.G.; Hsiao, T.; Hu, G.; Huang, J.J.; Husseini, A.; Hussen, M.M.; Hutfless, S.; Idrisov, B.; Ilesanmi, O.S.; Iqbal, U.; Irvani, S.S.N.; Irvine, C.M.S.; Islam, N.; Islam, S.M.S.; Islami, F.; Jacobsen, K.H.; Jahangiry, L.; Jahanmehr, N.; Jain, S.K.; Jakovljevic, M.; Jalu, M.T.; James, S.L.; Javanbakht, M.; Jayatilleke, A.U.; Jeemon, P.; Jenkins, K.J.; Jha, R.P.; Jha, V.; Johnson, C.O.; Johnson, S.C.; Jonas, J.B.; Joshi, A.; Jozwiak, J.J.; Jungari, S.B.; Jürisson, M.; Kabir, Z.; Kadel, R.; Kahsay, A.; Kalani, R.; Karami, M.; Karami Matin, B.; Karch, A.; Karema, C.; Karimi-Sari, H.; Kasaeian, A.; Kassa, D.H.; Kassa, G.M.; Kassa, T.D.; Kassebaum, N.J.; Katikireddi, S.V.; Kaul, A.; Kazemi, Z.; Karyani, A.K.; Kazi, D.S.; Kefale, A.T.; Keiyoro, P.N.; Kemp, G.R.; Kengne, A.P.; Keren, A.; Kesavachandran, C.N.; Khader, Y.S.; Khafaei, B.; Khafaie, M.A.; Khajavi, A.; Khalid, N.; Khalil, I.A.; Khan, E.A.; Khan, M.S.; Khan, M.A.; Khang, Y-H.; Khater, M.M.; Khoja, A.T.; Khosravi, A.; Khosravi, M.H.; Khubchandani, J.; Kiadaliri, A.A.; Kibret, G.D.; Kidanemariam, Z.T.; Kiirithio, D.N.; Kim, D.; Kim, Y-E.; Kim, Y.J.; Kimokoti, R.W.; Kinfu, Y.; Kisa, A.; Kissimova-Skarbek, K.; Kivimäki, M.; Knudsen, A.K.S.; Kocarnik, J.M.; Kochhar, S.; Kokubo, Y.; Kolola, T.; Kopec, J.A.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.A.; Krishan, K.; Kuate Defo, B.; Kucuk Bicer, B.; Kumar, G.A.; Kumar, M.; Kumar, P.; Kutz, M.J.; Kuzin, I.; Kyu, H.H.; Lad, D.P.; Lad, S.D.; Lafranconi, A.; Lal, D.K.; Lalloo, R.; Lallukka, T.; Lam, J.O.; Lami, F.H.; Lansingh, V.C.; Lansky, S.; Larson, H.J.; Latifi, A.; Lau, K.M-M.; Lazarus, J.V.; Lebedev, G.; Lee, P.H.; Leigh, J.; Leili, M.; Leshargie, C.T.; Li, S.; Li, Y.; Liang, J.; Lim, L-L.; Lim, S.S.; Limenih, M.A.; Linn, S.; Liu, S.; Liu, Y.; Lodha, R.; Lonsdale, C.; Lopez, A.D.; Lorkowski, S.; Lotufo, P.A.; Lozano, R.; Lunevicius, R.; Ma, S.; Macarayan, E.R.K.; Mackay, M.T.; MacLachlan, J.H.; Maddison, E.R.; Madotto, F.; Magdy Abd El Razek, H.; Magdy Abd El Razek, M.; Maghavani, D.P.; Majdan, M.; Majdzadeh, R.; Majeed, A.; Malekzadeh, R.; Malta, D.C.; Manda, A-L.; Mandarano-Filho, L.G.; Manguerra, H.; Mansournia, M.A.; Mapoma, C.C.; Marami, D.; Maravilla, J.C.; Marcenes, W.; Marczak, L.; Marks, A.; Marks, G.B.; Martinez, G.; Martins-Melo, F.R.; Martopullo, I.; März, W.; Marzan, M.B.; Masci, J.R.; Massenburg, B.B.; Mathur, M.R.; Mathur, P.; Matzopoulos, R.; Maulik, P.K.; Mazidi, M.; McAlinden, C.; McGrath, J.J.; McKee, M.; McMahon, B.J.; Mehata, S.; Mehndiratta, M.M.; Mehrotra, R.; Mehta, K.M.; Mehta, V.; Mekonnen, T.C.; Melese, A.; Melku, M.; Memiah, P.T.N.; Memish, Z.A.; Mendoza, W.; Mengistu, D.T.; Mengistu, G.; Mensah, G.A.; Mereta, S.T.; Meretoja, A.; Meretoja, T.J.; Mestrovic, T.; Mezgebe, H.B.; Miazgowski, B.; Miazgowski, T.; Millear, A.I.; Miller, T.R.; Miller-Petrie, M.K.; Mini, G.K.; Mirabi, P.; Mirarefin, M.; Mirica, A.; Mirrakhimov, E.M.; Misganaw, A.T.; Mitiku, H.; Moazen, B.; Mohammad, K.A.; Mohammadi, M.; Mohammadifard, N.; Mohammed, M.A.; Mohammed, S.; Mohan, V.; Mokdad, A.H.; Molokhia, M.; Monasta, L.; Moradi, G.; Moradi-Lakeh, M.; Moradinazar, M.; Moraga, P.; Morawska, L.; Moreno Velásquez, I.; Morgado-Da-Costa, J.; Morrison, S.D.; Moschos, M.M.; Mouodi, S.; Mousavi, S.M.; Muchie, K.F.; Mueller, U.O.; Mukhopadhyay, S.; Muller, K.; Mumford, J.E.; Musa, J.; Musa, K.I.; Mustafa, G.; Muthupandian, S.; Nachega, J.B.; Nagel, G.; Naheed, A.; Nahvijou, A.; Naik, G.; Nair, S.; Najafi, F.; Naldi, L.; Nam, H.S.; Nangia, V.; Nansseu, J.R.; Nascimento, B.R.; Natarajan, G.; Neamati, N.; Negoi, I.; Negoi, R.I.; Neupane, S.; Newton, C.R.J.; Ngalesoni, F.N.; Ngunjiri, J.W.; Nguyen, A.Q.; Nguyen, G.; Nguyen, H.T.; Nguyen, H.T.; Nguyen, L.H.; Nguyen, M.; Nguyen, T.H.; Nichols, E.; Ningrum, D.N.A.; Nirayo, Y.L.; Nixon, M.R.; Nolutshungu, N.; Nomura, S.; Norheim, O.F.; Noroozi, M.; Norrving, B.; Noubiap, J.J.; Nouri, H.R.; Nourollahpour Shiadeh, M.; Nowroozi, M.R.; Nyasulu, P.S.; Odell, C.M.; Ofori-Asenso, R.; Ogbo, F.A.; Oh, I-H.; Oladimeji, O.; Olagunju, A.T.; Olivares, P.R.; Olsen, H.E.; Olusanya, B.O.; Olusanya, J.O.; Ong, K.L.; Ong, S.K.S.; Oren, E.; Orpana, H.M.; Ortiz, A.; Ortiz, J.R.; Otstavnov, S.S.; Øverland, S.; Owolabi, M.O.; Özdemir, R.; P A, M.; Pacella, R.; Pakhale, S.; Pakhare, A.P.; Pakpour, A.H.; Pana, A.; Panda-Jonas, S.; Pandian, J.D.; Parisi, A.; Park, E-K.; Parry, C.D.H.; Parsian, H.; Patel, S.; Pati, S.; Patton, G.C.; Paturi, V.R.; Paulson, K.R.; Pereira, A.; Pereira, D.M.; Perico, N.; Pesudovs, K.; Petzold, M.; Phillips, M.R.; Piel, F.B.; Pigott, D.M.; Pillay, J.D.; Pirsaheb, M.; Pishgar, F.; Polinder, S.; Postma, M.J.; Pourshams, A.; Poustchi, H.; Pujar, A.; Prakash, S.; Prasad, N.; Purcell, C.A.; Qorbani, M.; Quintana, H.; Quistberg, D.A.; Rade, K.W.; Radfar, A.; Rafay, A.; Rafiei, A.; Rahim, F.; Rahimi, K.; Rahimi-Movaghar, A.; Rahman, M.; Rahman, M.H.U.; Rahman, M.A.; Rai, R.K.; Rajsic, S.; Ram, U.; Ranabhat, C.L.; Ranjan, P.; Rao, P.C.; Rawaf, D.L.; Rawaf, S.; Razo-García, C.; Reddy, K.S.; Reiner, R.C.; Reitsma, M.B.; Remuzzi, G.; Renzaho, A.M.N.; Resnikoff, S.; Rezaei, S.; Rezaeian, S.; Rezai, M.S.; Riahi, S.M.; Ribeiro, A.L.P.; Rios-Blancas, M.J.; Roba, K.T.; Roberts, N.L.S.; Robinson, S.R.; Roever, L.; Ronfani, L.; Roshandel, G.; Rostami, A.; Rothenbacher, D.; Roy, A.; Rubagotti, E.; Sachdev, P.S.; Saddik, B.; Sadeghi, E.; Safari, H.; Safdarian, M.; Safi, S.; Safiri, S.; Sagar, R.; Sahebkar, A.; Sahraian, M.A.; Salam, N.; Salama, J.S.; Salamati, P.; Saldanha, R.D.F.; Saleem, Z.; Salimi, Y.; Salvi, S.S.; Salz, I.; Sambala, E.Z.; Samy, A.M.; Sanabria, J.; Sanchez-Niño, M.D.; Santomauro, D.F.; Santos, I.S.; Santos, J.V.; Milicevic, M.M.S.; Sao Jose, B.P.; Sarker, A.R.; Sarmiento-Suárez, R.; Sarrafzadegan, N.; Sartorius, B.; Sarvi, S.; Sathian, B.; Satpathy, M.; Sawant, A.R.; Sawhney, M.; Saxena, S.; Sayyah, M.; Schaeffner, E.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schutte, A.E.; Schwebel, D.C.; Schwendicke, F.; Scott, J.G.; Sekerija, M.; Sepanlou, S.G.; Serván-Mori, E.; Seyedmousavi, S.; Shabaninejad, H.; Shackelford, K.A.; Shafieesabet, A.; Shahbazi, M.; Shaheen, A.A.; Shaikh, M.A.; Shams-Beyranvand, M.; Shamsi, M.; Shamsizadeh, M.; Sharafi, K.; Sharif, M.; Sharif-Alhoseini, M.; Sharma, R.; She, J.; Sheikh, A.; Shi, P.; Shiferaw, M.S.; Shigematsu, M.; Shiri, R.; Shirkoohi, R.; Shiue, I.; Shokraneh, F.; Shrime, M.G.; Si, S.; Siabani, S.; Siddiqi, T.J.; Sigfusdottir, I.D.; Sigurvinsdottir, R.; Silberberg, D.H.; Silva, D.A.S.; Silva, J.P.; Silva, N.T.D.; Silveira, D.G.A.; Singh, J.A.; Singh, N.P.; Singh, P.K.; Singh, V.; Sinha, D.N.; Sliwa, K.; Smith, M.; Sobaih, B.H.; Sobhani, S.; Sobngwi, E.; Soneji, S.S.; Soofi, M.; Sorensen, R.J.D.; Soriano, J.B.; Soyiri, I.N.; Sposato, L.A.; Sreeramareddy, C.T.; Srinivasan, V.; Stanaway, J.D.; Starodubov, V.I.; Stathopoulou, V.; Stein, D.J.; Steiner, C.; Stewart, L.G.; Stokes, M.A.; Subart, M.L.; Sudaryanto, A.; Sufiyan, M.B.; Sur, P.J.; Sutradhar, I.; Sykes, B.L.; Sylaja, P.N.; Sylte, D.O.; Szoeke, C.E.I.; Tabarés-Seisdedos, R.; Tabuchi, T.; Tadakamadla, S.K.; Takahashi, K.; Tandon, N.; Tassew, S.G.; Taveira, N.; Tehrani-Banihashemi, A.; Tekalign, T.G.; Tekle, M.G.; Temsah, M-H.; Temsah, O.; Terkawi, A.S.; Teshale, M.Y.; Tessema, B.; Tessema, G.A.; Thankappan, K.R.; Thirunavukkarasu, S.; Thomas, N.; Thrift, A.G.; Thurston, G.D.; Tilahun, B.; To, Q.G.; Tobe-Gai, R.; Tonelli, M.; Topor-Madry, R.; Torre, A.E.; Tortajada-Girbés, M.; Touvier, M.; Tovani-Palone, M.R.; Tran, B.X.; Tran, K.B.; Tripathi, S.; Troeger, C.E.; Truelsen, T.C.; Truong, N.T.; Tsadik, A.G.; Tsoi, D.; Tudor Car, L.; Tuzcu, E.M.; Tyrovolas, S.; Ukwaja, K.N.; Ullah, I.; Undurraga, E.A.; Updike, R.L.; Usman, M.S.; Uthman, O.A.; Uzun, S.B.; Vaduganathan, M.; Vaezi, A.; Vaidya, G.; Valdez, P.R.; Varavikova, E.; Vasankari, T.J.; Venketasubramanian, N.; Villafaina, S.; Violante, F.S.; Vladimirov, S.K.; Vlassov, V.; Vollset, S.E.; Vos, T.; Wagner, G.R.; Wagnew, F.S.; Waheed, Y.; Wallin, M.T.; Walson, J.L.; Wang, Y.; Wang, Y-P.; Wassie, M.M.; Weiderpass, E.; Weintraub, R.G.; Weldegebreal, F.; Weldegwergs, K.G.; Werdecker, A.; Werkneh, A.A.; West, T.E.; Westerman, R.; Whiteford, H.A.; Widecka, J.; Wilner, L.B.; Wilson, S.; Winkler, A.S.; Wiysonge, C.S.; Wolfe, C.D.A.; Wu, S.; Wu, Y-C.; Wyper, G.M.A.; Xavier, D.; Xu, G.; Yadgir, S.; Yadollahpour, A.; Yahyazadeh Jabbari, S.H.; Yakob, B.; Yan, L.L.; Yano, Y.; Yaseri, M.; Yasin, Y.J.; Yentür, G.K.; Yeshaneh, A.; Yimer, E.M.; Yip, P.; Yirsaw, B.D.; Yisma, E.; Yonemoto, N.; Yonga, G.; Yoon, S-J.; Yotebieng, M.; Younis, M.Z.; Yousefifard, M.; Yu, C.; Zadnik, V.; Zaidi, Z.; Zaman, S.B.; Zamani, M.; Zare, Z.; Zeleke, A.J.; Zenebe, Z.M.; Zhang, A.L.; Zhang, K.; Zhou, M.; Zodpey, S.; Zuhlke, L.J.; Naghavi, M.; Murray, C.J.L. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159), 1736-1788. doi: 10.1016/S0140-6736(18)32203-7 PMID: 30496103
  7. Cui, S.; Chen, S.; Wu, Q.; Chen, T.; Li, S. A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza. Int. Immunopharmacol., 2020, 81106040. doi: 10.1016/j.intimp.2019.106040 PMID: 31818704
  8. To, K-I.; Zhu, Z-X.; Wang, Y-N. Integrative network pharmacology and experimental verification to reveal the anti-inflammatory mechanism of ginsenoside Rh4. Front. Pharmacol., 2022, 13, 1-13. doi: 10.3389/fphar.2022.953871
  9. Zhang, W.; Sun, C.; Zhou, S.; Zhao, W.; Wang, L.; Sheng, L.; Yi, J.; Liu, T.; Yan, J.; Ma, X.; Fang, B. Recent advances in chemistry and bioactivity of Sargentodoxa cuneata. J. Ethnopharmacol., 2021, 270113840. doi: 10.1016/j.jep.2021.113840 PMID: 33460761
  10. Hu, L.; Chen, Y.; Chen, T. A systematic study of mechanism of sargentodoxa cuneata and patrinia scabiosifolia against pelvic inflammatory disease with dampness-heat stasis syndrome via network pharmacology approach. Front. Pharmacol., 2020, 11, 1-13. doi: 10.3389/fphar.2020.582520
  11. Zhang, R.; Zhu, X.; Bai, H. Network pharmacology databases for traditional chinese medicine: review and assessment. Front. Pharmacol., 2019, 10, 123.
  12. Sharma, R.; Singla, R.K.; Banerjee, S. Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation. Front. Nutr., 9, 1-23. doi: 10.3389/fnut.2022.1063118
  13. Sharma, R.; Singla, R.K.; Banerjee, S.; Sinha, B.; Shen, B.; Sharma, R. Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies. Neurosci. Biobehav. Rev., 2022, 140104795. doi: 10.1016/j.neubiorev.2022.104795 PMID: 35878793
  14. Vakser, I.A. Protein-protein docking: from interaction to interactome. Biophys J., 2014, 107(8), 1785-1793.
  15. Xue, L.C.; Dobbs, D.; Honavar, V. Computational prediction of protein interfaces: A review of data driven methods. FEBS Lett., 2015, 58923, 3516-3526.
  16. Liu, J.; Liu, J.; Tong, X.; Peng, W.; Wei, S.; Sun, T.; Wang, Y.; Zhang, B.; Li, W. Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis. Drug Des. Devel. Ther., 2021, 15, 3255-3276. doi: 10.2147/DDDT.S319786 PMID: 34349502
  17. Ru, J.; Li, P.; Wang, J. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J. Cheminform., 2014, 6, 13.
  18. Xu, H.Y.; Zhang, Y.Q.; Liu, Z.M.; Chen, T.; Lv, C.Y.; Tang, S.H.; Zhang, X.B.; Zhang, W.; Li, Z.Y.; Zhou, R.R.; Yang, H.J.; Wang, X.J.; Huang, L.Q. ETCM: an encyclopaedia of traditional Chinese medicine. Nucleic Acids Res., 2019, 47(D1), D976-D982. doi: 10.1093/nar/gky987 PMID: 30365030
  19. Daina, A.; Michielin, O.; Zoete, V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res., 2019, 47(W1), W357-W364. doi: 10.1093/nar/gkz382 PMID: 31106366
  20. UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res., 2021, 49, D480-D489.
  21. McNeill, A. Fond farewell to clinical utility gene cards. Eur. J. Hum. Genet., 2021, 29(10), 1473-1474. doi: 10.1038/s41431-021-00957-z PMID: 34497400
  22. Wishart, D.S.; Knox, C.; Guo, A.C.; Shrivastava, S.; Hassanali, M.; Stothard, P.; Chang, Z.; Woolsey, J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res., 2006, 34(90001), D668-D672. doi: 10.1093/nar/gkj067 PMID: 16381955
  23. Chen, X.; Ji, Z.L.; Chen, Y.Z. TTD: Therapeutic Target Database. Nucleic Acids Res., 2002, 30(1), 412-415. doi: 10.1093/nar/30.1.412 PMID: 11752352
  24. Amberger, J.S.; Bocchini, C.A.; Schiettecatte, F. OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders. Nucleic Acids Res., 2015, 43, D789-D798.
  25. Dalmaijer, E.S.; Nord, C.L.; Astle, D.E. Statistical power for cluster analysis. BMC Bioinformatics, 2022, 23(1), 205. doi: 10.1186/s12859-022-04675-1 PMID: 35641905
  26. Kang, J.K.; Chung, Y.C.; Hyun, C.G. Anti-Inflammatory Effects of 6-Methylcoumarin in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and NF-κB Signaling Pathways. Molecules, 2021, 26(17), 5351. doi: 10.3390/molecules26175351 PMID: 34500784
  27. Amatya, N.; Garg, A.V.; Gaffen, S.L. IL-17 Signaling: The Yin and the Yang. Trends Immunol., 2017, 38(5), 310-322. doi: 10.1016/j.it.2017.01.006 PMID: 28254169
  28. Fan, Y.; Wang, Y.; Yu, S.; Chang, J.; Yan, Y.; Wang, Y.; Bian, Y. Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a review. Chin. Med., 2021, 16(1), 67. doi: 10.1186/s13020-021-00478-3 PMID: 34321065
  29. Tang, H.; Yang, D.; Zhu, L. Paeonol interferes with quorum-sensing in pseudomonas aeruginosa and modulates inflammatory responses In Vitro and In Vivo. Front. Immunol., 2022, 13, 896874. doi: 10.3389/fimmu.2022.896874
  30. Picos-Salas, M.A.; Cabanillas-Bojórquez, L.Á.; Elizalde-Romero, C.A.; Leyva-López, N.; Montoya-Inzunza, L.A.; Heredia, J.B.; Gutiérrez-Grijalva, E.P. Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability. Food Rev. Int., 2022, 0, 1-39. doi: 10.1080/87559129.2022.2123502
  31. Hu, Y.; Huang, W.; Luo, Y.; Xiang, L.; Wu, J.; Zhang, Y.; Zeng, Y.; Xu, C.; Meng, X.; Wang, P. Assessment of the anti-inflammatory effects of three rhubarb anthraquinones in LPS-Stimulated RAW264.7 macrophages using a pharmacodynamic model and evaluation of the structure-activity relationships. J. Ethnopharmacol., 2021, 273114027. doi: 10.1016/j.jep.2021.114027 PMID: 33741438
  32. Shen, S.C.; Lee, W.R.; Lin, H.Y.; Huang, H.C.; Ko, C.H.; Yang, L.L.; Chen, Y.C. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production. Eur. J. Pharmacol., 2002, 446(1-3), 187-194. doi: 10.1016/S0014-2999(02)01792-2 PMID: 12098601
  33. Tang, N-Y.; Yang, J-S.; Chang, Y-H.; Lu, H.F.; Hsia, T.C.; Lin, W.C.; Chung, J.G. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. In Vivo, 2006, 20(4), 527-532. PMID: 16900784
  34. Yao, J.; Pan, D.; Zhao, Y.; Zhao, L.; Sun, J.; Wang, Y.; You, Q.D.; Xi, T.; Guo, Q.L.; Lu, N. Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology, 2014, 143(2), 241-257. doi: 10.1111/imm.12305 PMID: 24766487
  35. Liu, M.; Fang, G.; Yin, S.; Zhao, X.; Zhang, C.; Li, J.; Liu, Z. Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF- κ B and MAPK Activation. Mediators Inflamm., 2019, 2019, 1-12. doi: 10.1155/2019/1897820 PMID: 31182930

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