Mortality Risk Factors Among People Living with HIV Receiving Second-line Antiretroviral Therapy in Rural China
- Authors: Kang Q.1, Pan W.2, Ma Y.3, Wang D.1, Jia H.1, Guo H.4, Sang F.5, Xu L.4, Xu Q.6, Jin Y.4
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Affiliations:
- The First Clinical Medical School, Henan University of Chinese Medicine
- The First Clinical Medical Schoo, Henan University of Chinese Medicin
- Center for AIDS/STD Control and Prevention, Center for Disease Control and Prevention of Henan Province
- Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine
- Henan Key Laboratory of Viral Diseases Prevention and Treatment of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou
- The First Clinical Medical School, Henan University of Chinese Medicine,
- Issue: Vol 22, No 2 (2024)
- Pages: 100-108
- Section: Medicine
- URL: https://rjpbr.com/1570-162X/article/view/644029
- DOI: https://doi.org/10.2174/011570162X280721240108065502
- ID: 644029
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Abstract
Background:Second-line antiretroviral therapy (ART) was introduced in Henan Province in 2009. The number of people living with human immunodeficiency virus (HIV) starting this therapy is increasing.
Objective:This study aimed to investigate the survival and factors affecting mortality among this group.
Methods:We conducted a retrospective cohort study of people living with HIV (PLHIV) who switched to second-line ART between May 1, 2010, and May 1, 2016, using the KaplanMeier method and Cox proportional hazards models.
Results:We followed 3,331 PLHIV for 26,988 person-years, of whom 508 (15.3%) died. The mortality rate was 1.88/100 person-years. After adjusting for confounding factors, we found being a woman (hazard ratio (HR), 0.66; 95% confidence interval (CI) 0.550.79), > 50 years old (HR, 2.69; 95% CI, 2.033.56), single/widowed (HR, 1.26; 95% CI, 1.041.52), having > 6 years of education (HR, 0.78; 95% CI, 0.650.94), Chinese medicine (HR, 0.75; 95% CI, 0.520.96), liver injury (HR, 1.58; 95% CI, 1.192.10), and CD4+ T cell counp <000 cells/µl (HR, 1.94; 95% CI, 1.47-2.55), or 200-350 cells/µl (HR, 1.37; 95% CI, 1.031.82) were associated with mortality risk.
Conclusions:We found lower mortality among PLHIV who switched to second-line ART than most previous studies. The limitations of a retrospective cohort may, therefore, have biased the data, and prospective studies are needed to confirm the results. Moreover, Chinese medicine combined with second-line ART shows potential as a treatment for HIV.
About the authors
Qiujia Kang
The First Clinical Medical School, Henan University of Chinese Medicine
Email: info@benthamscience.net
Wanqi Pan
The First Clinical Medical Schoo, Henan University of Chinese Medicin
Email: info@benthamscience.net
Yanmin Ma
Center for AIDS/STD Control and Prevention, Center for Disease Control and Prevention of Henan Province
Email: info@benthamscience.net
Dongli Wang
The First Clinical Medical School, Henan University of Chinese Medicine
Email: info@benthamscience.net
Huangchao Jia
The First Clinical Medical School, Henan University of Chinese Medicine
Email: info@benthamscience.net
Huijun Guo
Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine
Email: info@benthamscience.net
Feng Sang
Henan Key Laboratory of Viral Diseases Prevention and Treatment of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou
Email: info@benthamscience.net
Liran Xu
Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine
Email: info@benthamscience.net
Qianlei Xu
The First Clinical Medical School, Henan University of Chinese Medicine,
Author for correspondence.
Email: info@benthamscience.net
Yantao Jin
Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine
Author for correspondence.
Email: info@benthamscience.net
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