Mortality Risk Factors Among People Living with HIV Receiving Second-line Antiretroviral Therapy in Rural China

  • Authors: Kang Q.1, Pan W.2, Ma Y.3, Wang D.1, Jia H.1, Guo H.4, Sang F.5, Xu L.4, Xu Q.6, Jin Y.4
  • Affiliations:
    1. The First Clinical Medical School, Henan University of Chinese Medicine
    2. The First Clinical Medical Schoo, Henan University of Chinese Medicin
    3. Center for AIDS/STD Control and Prevention, Center for Disease Control and Prevention of Henan Province
    4. Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine
    5. Henan Key Laboratory of Viral Diseases Prevention and Treatment of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou
    6. The First Clinical Medical School, Henan University of Chinese Medicine,
  • Issue: Vol 22, No 2 (2024)
  • Pages: 100-108
  • Section: Medicine
  • URL: https://rjpbr.com/1570-162X/article/view/644029
  • DOI: https://doi.org/10.2174/011570162X280721240108065502
  • ID: 644029

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Abstract

Background:Second-line antiretroviral therapy (ART) was introduced in Henan Province in 2009. The number of people living with human immunodeficiency virus (HIV) starting this therapy is increasing.

Objective:This study aimed to investigate the survival and factors affecting mortality among this group.

Methods:We conducted a retrospective cohort study of people living with HIV (PLHIV) who switched to second-line ART between May 1, 2010, and May 1, 2016, using the Kaplan–Meier method and Cox proportional hazards models.

Results:We followed 3,331 PLHIV for 26,988 person-years, of whom 508 (15.3%) died. The mortality rate was 1.88/100 person-years. After adjusting for confounding factors, we found being a woman (hazard ratio (HR), 0.66; 95% confidence interval (CI) 0.55–0.79), > 50 years old (HR, 2.69; 95% CI, 2.03–3.56), single/widowed (HR, 1.26; 95% CI, 1.04–1.52), having > 6 years of education (HR, 0.78; 95% CI, 0.65–0.94), Chinese medicine (HR, 0.75; 95% CI, 0.52–0.96), liver injury (HR, 1.58; 95% CI, 1.19–2.10), and CD4+ T cell counp <000 cells/µl (HR, 1.94; 95% CI, 1.47-2.55), or 200-350 cells/µl (HR, 1.37; 95% CI, 1.03–1.82) were associated with mortality risk.

Conclusions:We found lower mortality among PLHIV who switched to second-line ART than most previous studies. The limitations of a retrospective cohort may, therefore, have biased the data, and prospective studies are needed to confirm the results. Moreover, Chinese medicine combined with second-line ART shows potential as a treatment for HIV.

About the authors

Qiujia Kang

The First Clinical Medical School, Henan University of Chinese Medicine

Email: info@benthamscience.net

Wanqi Pan

The First Clinical Medical Schoo, Henan University of Chinese Medicin

Email: info@benthamscience.net

Yanmin Ma

Center for AIDS/STD Control and Prevention, Center for Disease Control and Prevention of Henan Province

Email: info@benthamscience.net

Dongli Wang

The First Clinical Medical School, Henan University of Chinese Medicine

Email: info@benthamscience.net

Huangchao Jia

The First Clinical Medical School, Henan University of Chinese Medicine

Email: info@benthamscience.net

Huijun Guo

Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine

Email: info@benthamscience.net

Feng Sang

Henan Key Laboratory of Viral Diseases Prevention and Treatment of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou

Email: info@benthamscience.net

Liran Xu

Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine

Email: info@benthamscience.net

Qianlei Xu

The First Clinical Medical School, Henan University of Chinese Medicine,

Author for correspondence.
Email: info@benthamscience.net

Yantao Jin

Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, First Affiliated Hospital of Henan University of Chinese Medicine

Author for correspondence.
Email: info@benthamscience.net

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