Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article


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Abstract

Insomnia is repeated difficulty in falling asleep, maintaining sleep, or experiencing lowquality sleep, resulting in some form of daytime disturbance. Sleeping disorders cause daytime fatigue, mental confusion, and over-sensitivity due to insufficient recovery from a sound sleep. There are some drugs, such as benzodiazepines and anti-histaminic agents, which help to sleep induction and insomnia cure. However, the prolonged administration is unsuitable because of tolerance and dependence. Therefore, the researchers attempt to find new medicines with lesser adverse effects. Natural products have always been good sources for developing new therapeutics for managing diseases such as cancer, cardiovascular disease, diabetes, insomnia, and liver and renal problems. Ample research has justified the acceptable reason and relevance of the use of these herbs in the treatment of insomnia. It is worth noting that in this study, we looked into various Persian herbs in a clinical trial and in vivo to treat insomnia, such as Artemisia annua, Salvia reuterana, Viola tricolor, Passiflora incarnata, lettuce, and Capparis spinose. According to research, herb extracts and fractions, particularly n-butanol fractions with non-polar agents, impact the benzodiazepine receptors and have hypnotic properties. Also, alkaloids, glycosides, flavonoids, saponins, and tannins in practically every plant are mentioned making them the popular natural compounds to help with sleep disorders and promote calmness.

About the authors

Azar Hosseini

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Leila Mobasheri

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Hassan Rakhshandeh

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Vafa Rahimi

Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Zohreh Najafi

Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad

Email: info@benthamscience.net

Vahid Askari

International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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