Ocrelizumab Extended Interval Dosing in Primary Progressive Multiple Sclerosis: An Italian Experience


Дәйексөз келтіру

Толық мәтін

Аннотация

Background:The intervals between two courses of anti CD20 therapies in the COVID19 pandemic era provided the opportunity to individually delay therapy, known as extended interval dosing (EID).

Materials and Methods:We collect real-world data on patients with primary progressive MS (PPMS) treated with Ocrelizumab (OCR) during the COVID’19 pandemic. The observation period in which the standard interval dosing (SID) or EID occurred (always a maintenance cycle, 600 mg) was from January 2020 to June 2021. All patients had two infusions during the observation period. Our first aim was to compare confirmed disability progression (CDP) between SID and EID patients.

Results:From a total cohort of 410 patients treated with OCR, 96 patients fulfilled the inclusion criteria. All patients received two infusions during the index window, 71 received only SID infusions whilst 25 received at least one EID infusion throughout the entire follow-up. During the entire available follow-up (median 10 months, IQR 7-11), CDP was recorded in 5 patients (3/71, 4.2% SID and 2/25, 8% EID, V-Cramer = 0.141, p-value = 0.167). EID regimen did not influence the risk of CDP during the investigated follow up.

Conclusion:In our multicentre real-world cohort, the EID regimen in PPMS patients did not result in increased CDP during the available follow-up.

Авторлар туралы

Aurora Zanghì

Department of Medical and Surgical Sciences, University of Foggia

Email: info@benthamscience.net

Diana Ferraro

, University of Modena and Reggio Emilia

Email: info@benthamscience.net

Graziella Callari

, IRCSS G.Giglio

Email: info@benthamscience.net

Paola Valentino

, Azienda Ospedaliera Universitaria "Mater Domini"

Email: info@benthamscience.net

Franco Granella

Unit of Neurosciences, Department of Medicine and Surgery, University of Parma

Email: info@benthamscience.net

Francesco Patti

Department "G.F. Ingrassia, MS center University of Catania

Email: info@benthamscience.net

Giacomo Lus

Multiple Sclerosis Center, II Division of Neurology, Department of Clinical and Experimental Medicine,, Second University of Naples

Email: info@benthamscience.net

Simona Bonavita

Dipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli,

Email: info@benthamscience.net

Maria Moretti

Department of Medical and Surgical Sciences, University of Foggia

Email: info@benthamscience.net

Carlo Avolio

Department of Medical and Surgical Sciences, University of Foggia

Email: info@benthamscience.net

Emanuele D’Amico

Department of Medical and Surgical Sciences,, University of Foggia,

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

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