The Diverse Network of Brain Histamine in Feeding: Dissect its Functions in a Circuit-Specific Way


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Abstract

Abstracts:Feeding is an intrinsic and important behavior regulated by complex molecular, cellular and circuit-level mechanisms, one of which is the brain histaminergic network. In the past decades, many studies have provided a foundation of knowledge about the relationship between feeding and histamine receptors, which are deemed to have therapeutic potential but are not successful in treating feeding- related diseases. Indeed, the histaminergic circuits underlying feeding are poorly understood and characterized. This review describes current knowledge of histamine in feeding at the receptor level. Further, we provide insight into putative histamine-involved feeding circuits based on the classic feeding circuits. Understanding the histaminergic network in a circuit-specific way may be therapeutically relevant for increasing the drug specificity and precise treatment in feeding-related diseases.

About the authors

Lingyu Xu

Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University

Email: info@benthamscience.net

Wenkai Lin

Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University

Email: info@benthamscience.net

Yanrong Zheng

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University

Email: info@benthamscience.net

Yi Wang

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University

Email: info@benthamscience.net

Zhong Chen

stitute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University

Author for correspondence.
Email: info@benthamscience.net

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