Targeting the Renin-Angiotensin System (RAS) for Neuropsychiatric Disorders

  • Authors: de Miranda A.1, Macedo D.2, Rocha N.3, Teixeira A.4
  • Affiliations:
    1. Faculty of Medicine, Interdisciplinary Laboratory of Medical Investigation (LIIM)
    2. Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Drug Research, and Development Center, Faculty of Medicine, Federal University of Ceara
    3. Department of Neurology, The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, McGovern Medical School, University of Texas Health Science Center at Houston
    4. Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, University of Texas Health Science Center at Houston
  • Issue: Vol 22, No 1 (2024)
  • Pages: 107-122
  • Section: Neurology
  • URL: https://rjpbr.com/1570-159X/article/view/644241
  • DOI: https://doi.org/10.2174/1570159X20666220927093815
  • ID: 644241

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Abstract

Background:Neuropsychiatric disorders, such as mood disorders, schizophrenia, and Alzheimer’s disease (AD) and related dementias, are associated to significant morbidity and mortality worldwide. The pathophysiological mechanisms of neuropsychiatric disorders remain to be fully elucidated, which has hampered the development of effective therapies. The Renin Angiotensin System (RAS) is classically viewed as a key regulator of cardiovascular and renal homeostasis. The discovery that RAS components are expressed in the brain pointed out a potential role for this system in central nervous system (CNS) pathologies. The understanding of RAS involvement in the pathogenesis of neuropsychiatric disorders may contribute to identifying novel therapeutic targets.

Objective:We aim to report current experimental and clinical evidence on the role of RAS in physiology and pathophysiology of mood disorders, schizophrenia, AD and related dementias. We also aim to discuss bottlenecks and future perspectives that can foster the development of new related therapeutic strategies.

Conclusion:The available evidence supports positive therapeutic effects for neuropsychiatric disorders with the inhibition/antagonism of the ACE/Ang II/AT1 receptor axis or the activation of the ACE2/Ang-(1-7)/Mas receptor axis. Most of this evidence comes from pre-clinical studies and clinical studies lag much behind, hampering a potential translation into clinical practice.

About the authors

Aline de Miranda

Faculty of Medicine, Interdisciplinary Laboratory of Medical Investigation (LIIM)

Author for correspondence.
Email: info@benthamscience.net

Danielle Macedo

Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Drug Research, and Development Center, Faculty of Medicine, Federal University of Ceara

Email: info@benthamscience.net

Natalia Rocha

Department of Neurology, The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, McGovern Medical School, University of Texas Health Science Center at Houston

Email: info@benthamscience.net

Antonio Teixeira

Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, University of Texas Health Science Center at Houston

Author for correspondence.
Email: info@benthamscience.net

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