PI3K Signaling Pathways as a Molecular Target for Glioblastoma Multiforme


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Abstract

Glioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical research aims to improve this prognosis by proposing the search for new drugs that effectively eliminate cancer cells, circumventing problems such as resistance to treatment. One of the promising therapeutic strategies in the treatment of GBM is the inhibition of the phosphatidylinositol 3-kinase (PI3K) pathway, which is closely related to the process of tumor carcinogenesis. This review sought to address the main scientific studies of synthetic or natural drug prototypes that target specific therapy co-directed via the PI3K pathway, against human glioblastoma.

About the authors

Andressa Letícia da Silva

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Thiago de Araújo

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Shakira de Albuquerque Ferreira

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Anderson Leite

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

João Kaycke da Silva

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Lilyana Albuquerque

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Ana Rachel de Lima

Federal University of Alagoas, Federal University of Alagoas

Email: info@benthamscience.net

Herbert Charles Silva Barros

Municipal Secretary of Health of Maceio, Governo do estado de Alagoas

Email: info@benthamscience.net

Leandro Silva

Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoa

Email: info@benthamscience.net

Edeildo da Silva-Júnior

Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas

Email: info@benthamscience.net

João de Araújo-Júnior

Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Vivaldo Neto

Paulo Niemeyer State Brain Institute, Study and Research Center, Brain Biomedicine Laboratory, Federal University of Rio de Janeiro

Email: info@benthamscience.net

Aline de Queiroz

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Email: info@benthamscience.net

Magna Alexandre-Moreira

Laboratory of Pharmacology and Immunity, Institute of Biological and Health Sciences, Federal University of Alagoas

Author for correspondence.
Email: info@benthamscience.net

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