The Future is Now for Precision Genomic Addiction Medicine as a Frontline Modality for Inducing "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS)


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Abstract

In this genomic era of addiction medicine, ideal treatment planning begins with genetic screening to determine neurogenetic antecedents of the Reward Deficiency Syndrome (RDS) phenotype. Patients suffering from endotype addictions, both substance and behavioral, and other mental health/comorbid disorders that share the neurobiological commonality of dopamine dysfunction, are ideal candidates for RDS solutions that facilitate dopamine homeostasis, addressing the cause, rather than symptoms. Our goal is to promote the interplay of molecular biology and recovery as well as provide evidence linked to RDS and its scientific basis to primary care physicians and others. This was an observational case study with a retrospective chart review in which an RDS treatment plan that utilized Genetic Addiction Risk Severity (GARS) analysis to evaluate neurogenetic challenges was used in order to develop appropriate short- and long-term pharmaceutical and nutraceutical interventions. A Substance Use Disorder (SUD) treatment-resistant patient was successfully treated utilizing the GARS test and RDS science. The RDS Solution Focused Brief Therapy (RDS-SFBT) and the RDS Severity of Symptoms Scale (SOS) may provide clinicians with a useful tool for establishing neurological balance and helping patients to achieve selfefficacy, self-actualization, and prosperity.

About the authors

Elizabeth Gilley

, The Elle Foundation

Author for correspondence.
Email: info@benthamscience.net

Abdalla Bowirrat

Department of Molecular Biology and Adelson School of Medicine, Ariel University

Email: info@benthamscience.net

Ashim Gupta

, Future Biologics

Email: info@benthamscience.net

John Giordano

, The National Institute of Holistic & Addiction Studies

Email: info@benthamscience.net

Catherine Dennen

Department of Family Medicine, Jefferson Health Northeast

Email: info@benthamscience.net

Eric Braverman

, The Kenneth Blum Institute of Behavior & Neurogenetics

Email: info@benthamscience.net

Rajendra Badgaiyan

Department of Psychiatry, Long School of Medicine, University of Texas Medical Center,

Email: info@benthamscience.net

Thomas McLaughlin

, The Kenneth Blum Institute of Behavior & Neurogenetics

Email: info@benthamscience.net

David Baron

Division of Addiction Research & Education, Center for Psychiatry, Medicine, Primary Care (Office of Provost), Western University Health Sciences

Email: info@benthamscience.net

Kenneth Blum

, The Kenneth Blum Institute of Behavior & Neurogenetics

Author for correspondence.
Email: info@benthamscience.net

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