FTO in Lung Cancer: Its Progression and Therapeutic Potential


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Abstract

One of the most fatal and frequent malignancies on the planet is lung cancer. Its occurrence and development are the results of multifactorial and multigenic interactions. In recent years, RNA N6-methyladenosine transferase (FTO) has gained significant attention in the field of oncology. FTO is the first RNA demethylase to be found to control target mRNA demethylation. The growth, proliferation, and metastasis of tumor cells are greatly influenced by FTO. Recent studies have found that imbalanced m6A methylation regulatory proteins can induce disruption of downstream RNA metabolism, strongly affecting tumor development. This paper provides an overview of the relationship between FTO and lung cancer, discussing the mechanisms by which FTO is involved in lung cancer and its potential clinical applications.

About the authors

Xue-Fen Chen

Geriatrics Respiratory Medicine Department, First Affiliated Hospital of GuangXi Medical University

Email: info@benthamscience.net

Chen Gong

Geriatrics Respiratory Medicine Department, First Affiliated Hospital of GuangXi Medical University

Author for correspondence.
Email: info@benthamscience.net

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