Is Ancient Medical Treatment an Option for Curating Osteosarcoma Combined with Chemotherapy? A Basic Analysis of Clinic Pharmacy


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Abstract

Background::As a malignant tumor, osteosarcoma (OS) ranks first place among adolescent cancers and is susceptible to developing resistance to chemotherapeutic agents. Differently, traditional Chinese medicine (TCM) has multiple pharmacodynamic targets and complex biological components, which can inhibit tumor survival and drug resistance and gradually play an important role in the treatment of sarcoma.

Methods::This study is to systematically evaluate the safety and efficacy of TCM combined with chemotherapy performed in the clinical treatment of OS. Based on multiple mainstream databases, eleven articles on the relationship between natural products and chemotherapy involving 656 patients were selected from all the literature published as of June 2022. Revman 5.4 software was used for a comprehensive search analysis, supplemented by established exclusion criteria, the Jadad scale, and the evaluation methods provided by Cochrane.

Results::The efficiency of TCM combined with chemotherapy was significantly increased compared with chemical drugs alone [OR=2.56, 95% CI (1.36,4.79), Z=2.92, P=0.003]. Meanwhile, the adverse reactions such as nausea and vomiting, hepatotoxicity, and hematological changes caused by chemical drugs were alleviated correspondingly.

Conclusion::This study indicates that the mode of TCM combined with chemotherapy sheds light on the clinical treatment of OS, which is much better than the one-way mode.

About the authors

Jian-yu Hu

, Dalian Municipal Central Hospital Affiliated of Dalian University of Technology

Email: info@benthamscience.net

Ya-ru Gao

School of Life and Pharmaceutical Sciences, Dalian University of Technology

Email: info@benthamscience.net

Yu-qi Bao

School of Life and Pharmaceutical Sciences, Dalian University of Technology

Email: info@benthamscience.net

Jing Zhao

School of Life and Pharmaceutical Sciences, Dalian University of Technology

Email: info@benthamscience.net

Bo Liu

School of Life and Pharmaceutical Sciences, Dalian University of Technology

Email: info@benthamscience.net

Chang-wei Zhao

, Affiliated Hospital of Changchun University of Traditional Chinese Medicine

Author for correspondence.
Email: info@benthamscience.net

Zheng-yao Zhang

School of Life and Pharmaceutical Sciences, Dalian University of Technology

Author for correspondence.
Email: info@benthamscience.net

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