Drug Delivery Systems based on Microneedles for Dermatological Diseases and Aesthetic Enhancement


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Аннотация

Microneedle (MN) devices comprise of micron-sized structures that circumvent biological barriers in a minimally invasive manner. MN research continues to grow and evolve; the technology was recently identified as one of the top ten overall emerging technologies of 2020. There is a growing interest in using such devices in cosmetology and dermatological conditions where the MNs mechanically disrupt the outer skin barrier layer, creating transient pathways that allow the passage of materials to underlying skin layers. This review aims to appraise the application of microneedle technologies in skin science, provide information on potential clinical benefits, as well as indicate possible dermatological conditions that can benefit from this technology, including autoimmunemediated inflammatory skin diseases, skin aging, hyperpigmentation, and skin tumors. A literature review was carried out to select studies that evaluated the use of microneedles to enhance drug delivery for dermatologic purposes. MN patches create temporary pathways that allow the passage of therapeutic material to deeper layers of the skin. Given their demonstrable promise in therapeutic applications it will be essential for healthcare professionals to engage with these new delivery systems as they transition to the clinic.

Об авторах

Mariane Vergilio

Graduate Program in Internal Medicine, School of Medical Sciences, University of Campinas (UNICAMP)

Email: info@benthamscience.net

James Birchall

School of Pharmacy and Pharmaceutical Sciences, Cardiff University

Email: info@benthamscience.net

Lonetá Lima

Renato Archer Information Technology Center (CTI), NT3D, Renato Archer Information Technology Center (CTI)

Email: info@benthamscience.net

Rodrigo Rezende

Renato Archer Information Technology Center (CTI), NT3D, Renato Archer Information Technology Center (CTI)

Email: info@benthamscience.net

Gislaine Leonardi

Graduate Program in Internal Medicine, School of Medical Sciences, University of Campinas (UNICAMP)

Автор, ответственный за переписку.
Email: info@benthamscience.net

Список литературы

  1. Fenner, J.; Clark, R.A.F. Anatomy, physiology, histology, and immunohistochemistry of human skin. In: Skin Tissue Engineering and Regenerative Medicine; Elsevier, 2016; pp. 1-17. doi: 10.1016/B978-0-12-801654-1.00001-2
  2. Norlén, L. Current understanding of skin barrier morphology. Skin Pharmacol. Physiol., 2013, 26(4-6), 213-216. doi: 10.1159/000351930 PMID: 23921107
  3. Alkilani, A.; McCrudden, M.T.; Donnelly, R. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics, 2015, 7(4), 438-470. doi: 10.3390/pharmaceutics7040438 PMID: 26506371
  4. El Maghraby, G.M.; Barry, B.W.; Williams, A.C. Liposomes and skin: From drug delivery to model membranes. Eur. J. Pharm. Sci., 2008, 34(4-5), 203-222. doi: 10.1016/j.ejps.2008.05.002 PMID: 18572392
  5. Yang, R.; Wei, T.; Goldberg, H.; Wang, W.; Cullion, K.; Kohane, D.S. Getting drugs across biological barriers. Adv. Mater., 2017, 29(37), 1606596. doi: 10.1002/adma.201606596 PMID: 28752600
  6. Bos, J.D.; Meinardi, M.M.H.M. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp. Dermatol., 2000, 9(3), 165-169. doi: 10.1034/j.1600-0625.2000.009003165.x PMID: 10839713
  7. Pathan, I.B.; Setty, C.M. Chemical penetration enhancers for transdermal drug delivery systems. Trop. J. Pharm. Res., 2009, 8(2) doi: 10.4314/tjpr.v8i2.44527
  8. Brown, M.B.; Martin, G.P.; Jones, S.A.; Akomeah, F.K. Dermal and transdermal drug delivery systems: Current and future prospects. Drug Deliv., 2006, 13(3), 175-187. doi: 10.1080/10717540500455975 PMID: 16556569
  9. Morrow, D.I.J.; McCarron, P.A.; Woolfson, A.D.; Donnelly, R.F. Innovative strategies for enhancing topical and transdermal drug delivery. Drug Deliv., 2007, 1(1), 36-59. doi: 10.2174/1874126600701010036
  10. Tran, T.N.T. Cutaneous drug delivery: An update. J. Investig. Dermatol. Symp. Proc., 2013, 16(1), S67-S69. doi: 10.1038/jidsymp.2013.28 PMID: 24326566
  11. Wokovich, A.; Prodduturi, S.; Doub, W.; Hussain, A.; Buhse, L. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eur. J. Pharm. Biopharm., 2006, 64(1), 1-8. doi: 10.1016/j.ejpb.2006.03.009 PMID: 16797171
  12. Donnelly, R.F.; Singh, T.R.R. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery; John Wiley & Sons, Ltd: Chichester, UK, 2015. doi: 10.1002/9781118734506
  13. Ingrole, R.S.J.; Azizoglu, E.; Dul, M.; Birchall, J.C.; Gill, H.S.; Prausnitz, M.R. Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity. Biomaterials, 2021, 267, 120491. doi: 10.1016/j.biomaterials.2020.120491 PMID: 33217629
  14. Gerstel, M.S.; Place, V.A. Place, Drug delivery device. US Patent 3964482 A, , 1976.
  15. Han, T.; Das, D.B. Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review. Eur. J. Pharm. Biopharm., 2015, 89, 312-328. doi: 10.1016/j.ejpb.2014.12.020 PMID: 25541440
  16. World Economic Forum Top 10 Emerging Technologies of 2020. World Econ. Forum., 2020, 1-25. Available from: http://www3.weforum.org/docs/WEF_Top_10_Emerging_Technologies_2020.pdf
  17. Arikat, F.; Hanna, S.J.; Singh, R.K.; Vilela, L.; Wong, F.S.; Dayan, C.M.; Coulman, S.A.; Birchall, J.C. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. J. Control. Release, 2020, 322, 593-601. doi: 10.1016/j.jconrel.2020.02.031 PMID: 32087298
  18. Davies, L.B.; Gateley, C.; Holland, P.; Coulman, S.A.; Birchall, J.C. Accelerating topical anaesthesia using microneedles. Skin Pharmacol. Physiol., 2017, 30(6), 277-283. doi: 10.1159/000479530 PMID: 28881348
  19. Kim, E.; Erdos, G.; Huang, S.; Kenniston, T.W.; Balmert, S.C.; Carey, C.D.; Raj, V.S.; Epperly, M.W.; Klimstra, W.B.; Haagmans, B.L.; Korkmaz, E.; Falo, L.D., Jr; Gambotto, A. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine, 2020, 55, 102743. doi: 10.1016/j.ebiom.2020.102743 PMID: 32249203
  20. Li, B.; Wang, J.; Yang, S.Y.; Zhou, C.; Wu, M.X. Sample-free quantification of blood biomarkers via laser-treated skin. Biomaterials, 2015, 59, 30-38. doi: 10.1016/j.biomaterials.2015.04.040 PMID: 25950985
  21. Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng., 2005, 52(5), 909-915. doi: 10.1109/TBME.2005.845240 PMID: 15887540
  22. Hu, Z.; Meduri, C.S.; Ingrole, R.S.J.; Gill, H.S.; Kumar, G. Solid and hollow metallic glass microneedles for transdermal drug-delivery. Appl. Phys. Lett., 2020, 116(20), 203703. doi: 10.1063/5.0008983
  23. Donnelly, R.F.; Morrow, D.I.J.; Singh, T.R.R.; Migalska, K.; McCarron, P.A.; O’Mahony, C.; Woolfson, A.D. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Ind. Pharm., 2009, 35(10), 1242-1254. doi: 10.1080/03639040902882280 PMID: 19555249
  24. Bolton, C.J.W.; Howells, O.; Blayney, G.J.; Eng, P.F.; Birchall, J.C.; Gualeni, B.; Roberts, K.; Ashraf, H.; Guy, O.J. Hollow silicon microneedle fabrication using advanced plasma etch technologies for applications in transdermal drug delivery. Lab Chip, 2020, 20(15), 2788-2795. doi: 10.1039/D0LC00567C PMID: 32632424
  25. Chen, Y.; Chen, B.Z.; Wang, Q.L.; Jin, X.; Guo, X.D. Fabrication of coated polymer microneedles for transdermal drug delivery. J. Control. Release, 2017, 265, 14-21. doi: 10.1016/j.jconrel.2017.03.383 PMID: 28344014
  26. Rzhevskiy, A.S.; Singh, T.R.R.; Donnelly, R.F.; Anissimov, Y.G. Microneedles as the technique of drug delivery enhancement in diverse organs and tissues. J. Control. Release, 2018, 270, 184-202. doi: 10.1016/j.jconrel.2017.11.048 PMID: 29203415
  27. Al-Qallaf, B.; Das, D.B. Optimization of square microneedle arrays for increasing drug permeability in skin. Chem. Eng. Sci., 2008, 63(9), 2523-2535. doi: 10.1016/j.ces.2008.02.007
  28. Al-Qallaf, B.; Das, D.B.; Mori, D.; Cui, Z. Modelling transdermal delivery of high molecular weight drugs from microneedle systems. Philos. Trans.- Royal Soc., Math. Phys. Eng. Sci., 2007, 365(1861), 2951-2967. doi: 10.1098/rsta.2007.0003 PMID: 17890186
  29. Al-Qallaf, B.; Das, D.B. Optimizing microneedle arrays for transdermal drug delivery: Extension to non-square distribution of microneedles. J. Drug Target., 2009, 17(2), 108-122. doi: 10.1080/10611860802472370 PMID: 19016071
  30. Olatunji, O.; Das, D.B.; Garland, M.J.; Belaid, L.; Donnelly, R.F. Influence of array interspacing on the force required for successful microneedle skin penetration: Theoretical and practical approaches. J. Pharm. Sci., 2013, 102(4), 1209-1221. doi: 10.1002/jps.23439 PMID: 23359221
  31. Yan, G.; Warner, K.S.; Zhang, J.; Sharma, S.; Gale, B.K. Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. Int. J. Pharm., 2010, 391(1-2), 7-12. doi: 10.1016/j.ijpharm.2010.02.007 PMID: 20188808
  32. Alimardani, V.; Abolmaali, S.S.; Tamaddon, A.M.; Ashfaq, M. Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy. Drug Deliv. Transl. Res., 2021, 11(3), 788-816. doi: 10.1007/s13346-020-00819-z PMID: 32740799
  33. Kim, M.; Yang, H.; Kim, H.; Jung, H.; Jung, H. Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles. Int. J. Cosmet. Sci., 2014, 36(3), 207-212. doi: 10.1111/ics.12115 PMID: 24910870
  34. Ita, K. Transdermal delivery of drugs with microneedles-potential and challenges. Pharmaceutics, 2015, 7(3), 90-105. doi: 10.3390/pharmaceutics7030090 PMID: 26131647
  35. Larrañeta, E.; Lutton, R.E.M.; Woolfson, A.D.; Donnelly, R.F. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Mater. Sci. Eng. R Reports, 2016, 104, 1-32. doi: 10.1016/j.mser.2016.03.001
  36. Liang, L.; Fei, W.M.; Zhao, Z.Q.; Hao, Y.Y.; Zhang, C.; Cui, Y.; Guo, X.D. Improved imiquimod-induced psoriasis like dermatitis using microneedles in mice. Eur. J. Pharm. Biopharm., 2021, 164, 20-27. doi: 10.1016/j.ejpb.2021.04.016 PMID: 33895291
  37. Mohammed, Y.H.; Yamada, M.; Lin, L.L.; Grice, J.E.; Roberts, M.S.; Raphael, A.P.; Benson, H.A.E.; Prow, T.W. Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin. PLoS One, 2014, 9(7), e101956. doi: 10.1371/journal.pone.0101956 PMID: 25033398
  38. Cárcamo-Martínez, Á.; Mallon, B.; Anjani, Q.K.; Domínguez-Robles, J.; Utomo, E.; Vora, L.K.; Tekko, I.A.; Larrañeta, E.; Donnelly, R.F. Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays. Int. J. Pharm., 2021, 593, 120152. doi: 10.1016/j.ijpharm.2020.120152 PMID: 33301867
  39. Ingrole, R.S.J.; Gill, H.S. Microneedle coating methods: A review with a perspective. J. Pharmacol. Exp. Ther., 2019, 370(3), 555-569. doi: 10.1124/jpet.119.258707 PMID: 31175217
  40. Tomono, T. A new way to control the internal structure of microneedles: A case of chitosan lactate. Mater. Today Chem., 2019, 13, 79-87. doi: 10.1016/j.mtchem.2019.04.009
  41. Zhao, X.; Coulman, S.A.; Hanna, S.J.; Wong, F.S.; Dayan, C.M.; Birchall, J.C. Formulation of hydrophobic peptides for skin delivery via coated microneedles. J. Control. Release, 2017, 265, 2-13. doi: 10.1016/j.jconrel.2017.03.015 PMID: 28286315
  42. Gill, H.S.; Prausnitz, M.R. Coated microneedles for transdermal delivery. J. Control. Release, 2007, 117(2), 227-237. doi: 10.1016/j.jconrel.2006.10.017 PMID: 17169459
  43. Ullah, A.; Khan, H.; Choi, H.J.; Kim, G.M. Smart microneedles with porous polymer coatings for pH-responsive drug delivery. Polymers, 2019, 11(11), 1834. doi: 10.3390/polym11111834 PMID: 31703443
  44. Ma, Y.; Tao, W.; Krebs, S.J.; Sutton, W.F.; Haigwood, N.L.; Gill, H.S. Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity. Pharm. Res., 2014, 31(9), 2393-2403. doi: 10.1007/s11095-014-1335-1 PMID: 24623480
  45. Jiang, J.; Gill, H.S.; Ghate, D.; McCarey, B.E.; Patel, S.R.; Edelhauser, H.F.; Prausnitz, M.R. Coated microneedles for drug delivery to the eye. Invest. Ophthalmol. Vis. Sci., 2007, 48(9), 4038-4043. doi: 10.1167/iovs.07-0066 PMID: 17724185
  46. Haj-Ahmad, R.; Khan, H.; Arshad, M.; Rasekh, M.; Hussain, A.; Walsh, S.; Li, X.; Chang, M.W.; Ahmad, Z. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics, 2015, 7(4), 486-502. doi: 10.3390/pharmaceutics7040486 PMID: 26556364
  47. Tarbox, T.N.; Watts, A.B.; Cui, Z.; Williams, R.O., III An update on coating/manufacturing techniques of microneedles. Drug Deliv. Transl. Res., 2018, 8(6), 1828-1843. doi: 10.1007/s13346-017-0466-4 PMID: 29288358
  48. Gao, Y.; Zhang, W.; Cheng, Y.F.; Cao, Y.; Xu, Z.; Xu, L.Q.; Kang, Y.; Xue, P. Intradermal administration of green synthesized nanosilver (NS) through film-coated PEGDA microneedles for potential antibacterial applications. Biomater. Sci., 2021, 9(6), 2244-2254. doi: 10.1039/D0BM02136A PMID: 33514957
  49. Hao, Y.; Dong, M.; Zhang, T.; Peng, J.; Jia, Y.; Cao, Y.; Qian, Z. Novel approach of using near-infrared responsive pegylated gold nanorod coated poly(L-lactide) microneedles to enhance the antitumor efficiency of docetaxel-loaded MPEG-PDLLA micelles for treating an A431 tumor. ACS Appl. Mater. Interfaces, 2017, 9(18), 15317-15327. doi: 10.1021/acsami.7b03604 PMID: 28418236
  50. Ruan, W.; Zhai, Y.; Yu, K.; Wu, C.; Xu, Y. Coated microneedles mediated intradermal delivery of octaarginine/BRAF siRNA nanocomplexes for anti-melanoma treatment. Int. J. Pharm., 2018, 553(1-2), 298-309. doi: 10.1016/j.ijpharm.2018.10.043 PMID: 30347273
  51. Chong, R.H.E.; Gonzalez-Gonzalez, E.; Lara, M.F.; Speaker, T.J.; Contag, C.H.; Kaspar, R.L.; Coulman, S.A.; Hargest, R.; Birchall, J.C. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. J. Control. Release, 2013, 166(3), 211-219. doi: 10.1016/j.jconrel.2012.12.030 PMID: 23313112
  52. Jain, A.K.; Lee, C.H.; Gill, H.S. 5-Aminolevulinic acid coated microneedles for photodynamic therapy of skin tumors. J. Control. Release, 2016, 239, 72-81. doi: 10.1016/j.jconrel.2016.08.015 PMID: 27543445
  53. Uddin, M.J.; Scoutaris, N.; Economidou, S.N.; Giraud, C.; Chowdhry, B.Z.; Donnelly, R.F.; Douroumis, D. 3D printed microneedles for anticancer therapy of skin tumours. Mater. Sci. Eng. C, 2020, 107, 110248. doi: 10.1016/j.msec.2019.110248 PMID: 31761175
  54. Lee, H.S.; Ryu, H.R.; Roh, J.Y.; Park, J.H. Bleomycin- coated microneedles for treatment of warts. Pharm. Res., 2017, 34(1), 101-112. doi: 10.1007/s11095-016-2042-x PMID: 27858218
  55. Ryu, H.R.; Jeong, H.R.; Seon-Woo, H.S.; Kim, J.S.; Lee, S.K.; Kim, H.J.; Baek, J.O.; Park, J.H.; Roh, J.Y. Efficacy of a bleomycin microneedle patch for the treatment of warts. Drug Deliv. Transl. Res., 2018, 8(1), 273-280. doi: 10.1007/s13346-017-0458-4 PMID: 29204924
  56. Chiu, T.M.; Hsu, P.C.; Khan, M.Y.; Lin, C.A.J.; Lee, C.H.; Hsu, T.C.; Chen, M.H.; Hanagata, N. A perspective on imiquimod microneedles for treating warts. Pharmaceutics, 2021, 13(5), 607. doi: 10.3390/pharmaceutics13050607 PMID: 33922157
  57. Donnelly, R.F.; Singh, T.R.R.; Morrow, D.I.J.; Woolfson, A.D. Microneedle-mediated Transdermal and Intradermal Drug Delivery; John Wiley & Sons, Ltd: Chichester, UK, 2012. doi: 10.1002/9781119959687
  58. Prausnitz, M.R. Microneedles for transdermal drug delivery. Adv. Drug Deliv. Rev., 2004, 56(5), 581-587. doi: 10.1016/j.addr.2003.10.023 PMID: 15019747
  59. Quinn, H.L.; Bonham, L.; Hughes, C.M.; Donnelly, R.F. Design of a dissolving microneedle platform for transdermal delivery of a fixed-dose combination of cardiovascular drugs. J. Pharm. Sci., 2015, 104(10), 3490-3500. doi: 10.1002/jps.24563 PMID: 26149914
  60. Tuan-Mahmood, T.M.; McCrudden, M.T.C.; Torrisi, B.M.; McAlister, E.; Garland, M.J.; Singh, T.R.R.; Donnelly, R.F. Microneedles for intradermal and transdermal drug delivery. Eur. J. Pharm. Sci., 2013, 50(5), 623-637. doi: 10.1016/j.ejps.2013.05.005 PMID: 23680534
  61. Lee, K.; Lee, C.Y.; Jung, H. Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials, 2011, 32(11), 3134-3140. doi: 10.1016/j.biomaterials.2011.01.014 PMID: 21292317
  62. Park, J.H.; Allen, M.G.; Prausnitz, M.R. Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. J. Control. Release, 2005, 104(1), 51-66. doi: 10.1016/j.jconrel.2005.02.002 PMID: 15866334
  63. Sullivan, S.P.; Koutsonanos, D.G.; del Pilar Martin, M.; Lee, J.W.; Zarnitsyn, V.; Choi, S.O.; Murthy, N.; Compans, R.W.; Skountzou, I.; Prausnitz, M.R. Dissolving polymer microneedle patches for influenza vaccination. Nat. Med., 2010, 16(8), 915-920. doi: 10.1038/nm.2182 PMID: 20639891
  64. Aoyagi, S.; Izumi, H.; Isono, Y.; Fukuda, M.; Ogawa, H. Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle. Sens. Actuators A Phys., 2007, 139(1-2), 293-302. doi: 10.1016/j.sna.2006.11.022
  65. Lee, J.W.; Park, J.H.; Prausnitz, M.R. Dissolving microneedles for transdermal drug delivery. Biomaterials, 2008, 29(13), 2113-2124. doi: 10.1016/j.biomaterials.2007.12.048 PMID: 18261792
  66. Han, M.; Kim, D.K.; Kang, S.H.; Yoon, H.R.; Kim, B.Y.; Lee, S.S.; Kim, K.D.; Lee, H.G. Improvement in antigen-delivery using fabrication of a grooves-embedded microneedle array. Sens. Actuators B Chem., 2009, 137(1), 274-280. doi: 10.1016/j.snb.2008.11.017
  67. Lippmann, J.M.; Geiger, E.J.; Pisano, A.P. Polymer investment molding: Method for fabricating hollow, microscale parts. Sens. Actuators A Phys., 2007, 134(1), 2-10. doi: 10.1016/j.sna.2006.05.009
  68. Pérennès, F.; Marmiroli, B.; Matteucci, M.; Tormen, M.; Vaccari, L.; Fabrizio, E.D. Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol. J. Micromech. Microeng., 2006, 16(3), 473-479. doi: 10.1088/0960-1317/16/3/001
  69. Sammoura, F.; Kang, J.; Heo, Y.M.; Jung, T.; Lin, L. Polymeric microneedle fabrication using a microinjection molding technique. Microsyst. Technol., 2007, 13(5-6), 517-522. doi: 10.1007/s00542-006-0204-1
  70. Choi, S.Y.; Kwon, H.J.; Ahn, G.R.; Ko, E.J.; Yoo, K.H.; Kim, B.J.; Lee, C.; Kim, D. Hyaluronic acid microneedle patch for the improvement of crow’s feet wrinkles. Dermatol. Ther., 2017, 30(6), e12546. doi: 10.1111/dth.12546 PMID: 28892233
  71. Moon, S.J.; Lee, S.S. A novel fabrication method of a microneedle array using inclined deep x-ray exposure. J. Micromech. Microeng., 2005, 15(5), 903-911. doi: 10.1088/0960-1317/15/5/002
  72. Ovsianikov, A.; Chichkov, B.; Mente, P.; Monteiro-Riviere, N.A.; Doraiswamy, A.; Narayan, R.J. Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery. Int. J. Appl. Ceram. Technol., 2007, 4(1), 22-29. doi: 10.1111/j.1744-7402.2007.02115.x
  73. Sullivan, S.P.; Murthy, N.; Prausnitz, M.R. Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv. Mater., 2008, 20(5), 933-938. doi: 10.1002/adma.200701205 PMID: 23239904
  74. Kolli, C.S.; Banga, A.K. Characterization of solid maltose microneedles and their use for transdermal delivery. Pharm. Res., 2008, 25(1), 104-113. doi: 10.1007/s11095-007-9350-0 PMID: 17597381
  75. Miyano, T.; Tobinaga, Y.; Kanno, T.; Matsuzaki, Y.; Takeda, H.; Wakui, M.; Hanada, K. Sugar micro needles as transdermic drug delivery system. Biomed. Microdevices, 2005, 7(3), 185-188. doi: 10.1007/s10544-005-3024-7 PMID: 16133805
  76. Martin, C.J.; Allender, C.J.; Brain, K.R.; Morrissey, A; Birchall, J.C. Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications, J. Control. Release, 2012, 158(1), 93-101 doi: 10.1016/j.jconrel.2011.1
  77. Du, H.; Liu, P.; Zhu, J.; Lan, J.; Li, Y.; Zhang, L.; Zhu, J.; Tao, J. Hyaluronic acid-based dissolving microneedle patch loaded with methotrexate for improved treatment of psoriasis. ACS Appl. Mater. Interfaces, 2019, 11(46), 43588-43598. doi: 10.1021/acsami.9b15668 PMID: 31651148
  78. Jang, M.; Kang, B.M.; Yang, H.; Ohn, J.; Kwon, O.; Jung, H. High-dose steroid dissolving microneedle for relieving atopic dermatitis. Adv. Healthc. Mater., 2021, 10(7), 2001691. doi: 10.1002/adhm.202001691 PMID: 33586358
  79. Xing, M.; Wang, X.; Zhao, L.; Zhou, Z.; Liu, H.; Wang, B.; Cheng, A.; Zhang, S.; Gao, Y. Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract. Int. J. Pharm., 2021, 600, 120406. doi: 10.1016/j.ijpharm.2021.120406 PMID: 33711468
  80. Aung, N.N.; Ngawhirunpat, T.; Rojanarata, T.; Patrojanasophon, P.; Opanasopit, P.; Pamornpathomkul, B. HPMC/PVP dissolving microneedles: A promising delivery platform to promote trans-epidermal delivery of alpha-arbutin for skin lightening. AAPS PharmSciTech, 2020, 21(1), 25. doi: 10.1208/s12249-019-1599-1 PMID: 31848807
  81. Zhang, L.Q.; Zhang, X.P.; Hao, Y.Y.; Zhang, B.L.; Guo, X.D. Codelivery of hydrophilic and hydrophobic drugs in a microneedle patch for the treatment of skin pigmentation. J. Ind. Eng. Chem., 2020, 88, 241-250. doi: 10.1016/j.jiec.2020.04.019
  82. Avcil, M.; Akman, G.; Klokkers, J.; Jeong, D.; Çelik, A. Clinical efficacy of dissolvable microneedles armed with anti-melanogenic compounds to counter hyperpigmentation. J. Cosmet. Dermatol., 2021, 20(2), 605-614. doi: 10.1111/jocd.13571 PMID: 32692898
  83. Fakhraei Lahiji, S.; Seo, S.H.; Kim, S.; Dangol, M.; Shim, J.; Li, C.G.; Ma, Y.; Lee, C.; Kang, G.; Yang, H.; Choi, K.Y.; Jung, H. Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth. Biomaterials, 2018, 167, 69-79. doi: 10.1016/j.biomaterials.2018.03.019 PMID: 29554482
  84. Xing, M.; Yang, G.; Zhang, S.; Gao, Y. Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. Eur. J. Pharm. Sci., 2021, 165, 105935. doi: 10.1016/j.ejps.2021.105935 PMID: 34284096
  85. Tan, C.W.X.; Tan, W.D.; Srivastava, R.; Yow, A.P.; Wong, D.W.K.; Tey, H.L. Dissolving triamcinolone-embedded microneedles for the treatment of keloids: A single-blinded intra-individual controlled clinical trial. Dermatol. Ther., 2019, 9(3), 601-611. doi: 10.1007/s13555-019-00316-3 PMID: 31376063
  86. Dong, L.; Li, Y.; Li, Z.; Xu, N.; Liu, P.; Du, H.; Zhang, Y.; Huang, Y.; Zhu, J.; Ren, G.; Xie, J.; Wang, K.; Zhou, Y.; Shen, C.; Zhu, J.; Tao, J. Au nanocage-strengthened dissolving microneedles for chemo-photothermal combined therapy of superficial skin tumors. ACS Appl. Mater. Interfaces, 2018, 10(11), 9247-9256. doi: 10.1021/acsami.7b18293 PMID: 29493217
  87. Requena, M.B.; Permana, A.D.; Vollet-Filho, J.D.; González-Vázquez, P.; Garcia, M.R.; De Faria, C.M.G.; Pratavieira, S.; Donnelly, R.F.; Bagnato, V.S. Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution. J. Biophotonics, 2021, 14(1), e202000128. doi: 10.1002/jbio.202000128 PMID: 32981235
  88. Qin, W.; Quan, G.; Sun, Y.; Chen, M.; Yang, P.; Feng, D.; Wen, T.; Hu, X.; Pan, X.; Wu, C. Dissolving microneedles with spatiotemporally controlled pulsatile release nanosystem for synergistic chemo-photothermal therapy of melanoma. Theranostics, 2020, 10(18), 8179-8196. doi: 10.7150/thno.44194 PMID: 32724465
  89. Permana, A.D.; Mir, M.; Utomo, E.; Donnelly, R.F. Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: A proof of concept study. Int. J. Pharm. X, 2020, 2, 100047. doi: 10.1016/j.ijpx.2020.100047 PMID: 32322819
  90. Permana, A.D.; Paredes, A.J.; Volpe-Zanutto, F.; Anjani, Q.K.; Utomo, E.; Donnelly, R.F. Dissolving microneedle- mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. Eur. J. Pharm. Biopharm., 2020, 154, 50-61. doi: 10.1016/j.ejpb.2020.06.025 PMID: 32649991
  91. Ohn, J.; Jang, M.; Kang, B.M.; Yang, H.; Hong, J.T.; Kim, K.H.; Kwon, O.; Jung, H. Dissolving candlelit microneedle for chronic inflammatory skin diseases. Adv. Sci., 2021, 8, 2004873. doi: 10.1002/advs.202004873
  92. Lee, J.H.; Jung, Y.S.; Kim, G.M.; Bae, J.M. A hyaluronic acid-based microneedle patch to treat psoriatic plaques: a pilot open trial. Br. J. Dermatol., 2018, 178. doi: 10.1111/bjd.15779
  93. Akilov, O.; McCann, S.; Erdos, G.; Falo, L.D. Phase 1, single-arm, open-label, dose escalation trial of microneedle array-doxorubicin in patients with mycosis fungoides. Eur. J. Cancer, 2018, 101, S32. doi: 10.1016/j.ejca.2018.07.290
  94. Zvezdin, V.; Peno-Mazzarino, L.; Radionov, N.; Kasatkina, T.; Kasatkin, I. Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality – Part 1: ex vivo safety evaluation. Int. J. Cosmet. Sci., 2020, 42, 369-376. doi: 10.1111/ics.12627
  95. Zvezdin, V.; Kasatkina, T.; Kasatkin, I.; Gavrilova, M.; Kazakova, O. Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical evaluation. Int. J. Cosmet. Sci., 2020, 42, 429-435. doi: 10.1111/ics.12636
  96. Jang, M.; Baek, S.; Kang, G.; Yang, H.; Kim, S.; Jung, H. Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity. Int. J. Cosmet. Sci., 2020, 42, 302-309. doi: 10.1111/ics.12617
  97. Kang, G.; Kim, S.; Yang, H.; Jang, M.; Chiang, L.; Baek, J.H.; Ryu, J.H.; Choi, G.W.; Jung, H. Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration. J. Cosmet. Dermatol., 2019, 18, 1083-1091. doi: 10.1111/jocd.12807
  98. Yang, H.; Kim, S.; Jang, M.; Kim, H.; Lee, S.; Kim, Y.; Eom, Y.A.; Kang, G.; Chiang, L.; Baek, J.H.; Ryu, J.H.; Lee, Y.E.; Koh, J.; Jung, H. Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. J. Cosmet. Dermatol., 2019, 18, 936-943. doi: 10.1111/jocd.12768
  99. Choi, J-T.; Park, S-J.; Park, J-H. Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behaviour after administration into skin. J. Drug Target., 2018, 26, 884-894. doi: 10.1080/1061186X.2018.1435664
  100. Donnelly, R.F.; Singh, T.R.R.; Garland, M.J.; Migalska, K.; Majithiya, R.; McCrudden, C.M.; Kole, P.L.; Mahmood, T.M.T.; McCarthy, H.O.; Woolfson, A.D. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv. Funct. Mater., 2012, 22. doi: 10.1002/adfm.201200864
  101. Pan, X.; Li, Y.; Pang, W.; Xue, Y.; Wang, Z.; Jiang, C.; Shen, C.; Liu, Q.; Liu, L. Preparation, characterisation and comparison of glabridin-loaded hydrogel-forming microneedles by chemical and physical cross-linking. Int. J. Pharm., 2022, 617, 121612. doi: 10.1016/J.IJPHARM.2022.121612
  102. Ranjan Yadav, P.; Iqbal Nasiri, M.; Vora, L.K.; Larrañeta, E.; Donnelly, R.F.; Pattanayek, S.K.; Bhusan Das, D. Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation. Int. J. Pharm., 2022, 622, 121835. doi: 10.1016/J.IJPHARM.2022.121835
  103. Aung, N.N.; Ngawhirunpat, T.; Rojanarata, T.; Patrojanasophon, P.; Pamornpathomkul, B.; Opanasopit, P. Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles. Int. J. Pharm., 2020, 586, 119508. doi: 10.1016/J.IJPHARM.2020.119508
  104. Donnelly, R.F.; McCrudden, M.T.C.; Alkilani, A.Z.; Larrañeta, E.; McAlister, E.; Courtenay, A.J.; Kearney, M.C.; Raj Singh, T.R.; McCarthy, H.O.; Kett, V.L.; Caffarel-Salvador, E.; Al-Zahrani, S.; Woolfson, A.D. Hydrogel-forming microneedles prepared from "super swelling" polymers combined with lyophilised wafers for transdermal drug delivery. PLoS One, 2014, 9. doi: 10.1371/journal.pone.0111547

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