The Function of Autophagy in the Initiation, and Development of Breast Cancer
- Authors: Beilankouhi E.A.1, Valilo M.2, Dastmalchi N.3, Teimourian S.4, Safaralizadeh R.1
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Affiliations:
- Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
- Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences
- Department of Biology, University College of Nabi Akram
- Department of Medical Genetics, School of Medicine, Iran University of Medical Science
- Issue: Vol 31, No 20 (2024)
- Pages: 2974-2990
- Section: Anti-Infectives and Infectious Diseases
- URL: https://rjpbr.com/0929-8673/article/view/645214
- DOI: https://doi.org/10.2174/0929867330666230503145319
- ID: 645214
Cite item
Full Text
Abstract
Autophagy is a significant catabolic procedure that increases in stressful conditions. This mechanism is mostly triggered after damage to the organelles, the presence of unnatural proteins, and nutrient recycling in reaction to these stresses. One of the key points in this article is that cleaning and preserving damaged organelles and accumulated molecules through autophagy in normal cells helps prevent cancer. Since dysfunction of autophagy is associated with various diseases, including cancer, it has a dual function in tumor suppression and expansion. It has newly become clear that the regulation of autophagy can be used for the treatment of breast cancer, which has a promising effect of increasing the efficiency of anticancer treatment in a tissue- and cell-type-specific manner by affecting the fundamental molecular mechanisms. Regulation of autophagy and its function in tumorigenesis is a vital part of modern anticancer techniques. This study discusses the current advances related to the mechanisms that describe essential modulators of autophagy involved in the metastasis of cancers and the development of new breast cancer treatments.
Keywords
About the authors
Elmira Aboutalebi Beilankouhi
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
Email: info@benthamscience.net
Mohammad Valilo
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences
Email: info@benthamscience.net
Narges Dastmalchi
Department of Biology, University College of Nabi Akram
Email: info@benthamscience.net
Shahram Teimourian
Department of Medical Genetics, School of Medicine, Iran University of Medical Science
Email: info@benthamscience.net
Reza Safaralizadeh
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
Author for correspondence.
Email: info@benthamscience.net
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