Therapeutic Potential of Iron Chelators in Viral Diseases: A Systematic Review
- Authors: Lori M.1, Khandani A.1, Dehghannoudeh G.2, Ohadi M.2, Ansari M.3
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Affiliations:
- Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences
- Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences
- Department of Drug and Food Control, Faculty of Pharmacy, Kerman University of Medical Sciences
- Issue: Vol 31, No 27 (2024)
- Pages: 4383-4391
- Section: Anti-Infectives and Infectious Diseases
- URL: https://rjpbr.com/0929-8673/article/view/644979
- DOI: https://doi.org/10.2174/0109298673259596231211113211
- ID: 644979
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Abstract
Background:Iron chelators (ICs) have recently emerged as one of the new methods of treatment for viral infections. This study aimed to evaluate the efficiency and safety of natural ICs compared to synthetic ICs. Natural and synthetic ICs are the most common therapeutic agents tested for the treatment of viral infections. When evaluated against synthetic ICs, natural ICs are probably favored owing to their lower toxicity and safer properties. The main objective of the present systematic review was to assess the current evidence on the role of pharmacological mechanisms in the treatment of viral infections.
Methods:This study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, "iron chelators" and "viral infection", was employed.
Results:According to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections via various mechanisms, with natural ICs being the most extensively used.
Conclusion:Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.
About the authors
Maryam Lori
Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences
Email: info@benthamscience.net
Azade Khandani
Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences
Email: info@benthamscience.net
Gholamreza Dehghannoudeh
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences
Email: info@benthamscience.net
Mandana Ohadi
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
Mehdi Ansari
Department of Drug and Food Control, Faculty of Pharmacy, Kerman University of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
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