Hybrids Diazine: Recent Advancements in Modern Antimicrobial Therapy


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Abstract

Nowadays, antimicrobial therapies have become a very challenging issue because of a large diversity of reasons such as antimicrobial resistance, over consumption and misuse of antimicrobial agents, etc. A modern, actual and very useful approach in antimicrobial therapy is represented by the use of hybrid drugs, especially combined five and six-membered ring azaheterocycles. In this review, we present an overview of the recent advanced data from the last five years in the field of hybrid diazine compounds with antimicrobial activity. In this respect, we highlight here essential data concerning the synthesis and antimicrobial activity of the main classes of diazine hybrids: pyridazine, pyrimidine, pyrazine, and their fused derivatives.

About the authors

Violeta Mangalagiu

Institute of Interdisciplinary Research – CERNESIM Center, Alexandru Ioan Cuza University of Iasi,

Email: info@benthamscience.net

Ramona Danac

Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi

Email: info@benthamscience.net

Dumitrela Diaconu

Institute of Interdisciplinary Research – CERNESIM Cente, Alexandru Ioan Cuza University of Iasi,

Author for correspondence.
Email: info@benthamscience.net

Gheorghita Zbancioc

Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi

Email: info@benthamscience.net

Ionel Mangalagiu

Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi

Author for correspondence.
Email: info@benthamscience.net

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