Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview


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Abstract

Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (-C=N-) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.

About the authors

Juliana Jorge

Instituto de Química,, Universidade Federal do Mato Grosso do Sul

Email: info@benthamscience.net

Kristiane Del Pino Santos

Instituto de Química, Universidade Federal do Mato Grosso do Sul,

Email: info@benthamscience.net

Fernanda Timóteo

Instituto de Química,, Universidade Federal do Mato Grosso do Sul

Email: info@benthamscience.net

Rafael Rodrigo Piva Vasconcelos

Instituto de Química, Universidade Federal do Mato Grosso do Sul

Email: info@benthamscience.net

Osmar Ignacio Ayala Cáceres

Instituto de Química,, Universidade Federal do Mato Grosso do Sul

Email: info@benthamscience.net

Isis Juliane Arantes Granja

Instituto de Química,, Universidade Federal de Goiás - UFG

Email: info@benthamscience.net

David de Souza

Instituto de Química,, Universidade Federal do Mato Grosso do Sul

Email: info@benthamscience.net

Tiago Elias Allievi Frizon

Department of Energy and Sustainability, Universidade Federal de Santa Catarina - UFSC

Email: info@benthamscience.net

Giancarlo Di Vaccari Botteselle

Departamento de Química,, Universidade Estadual do Centro-Oeste - UNICENTRO

Email: info@benthamscience.net

Antonio Luiz Braga

Departamento de Química, Universidade Federal de Santa Catarina,

Email: info@benthamscience.net

Sumbal Saba

Instituto de Química,, Universidade Federal de Goiás - UFG

Author for correspondence.
Email: info@benthamscience.net

Haroon Rashid

Instituto de Química,, Universidade Federal do Mato Grosso do Sul

Author for correspondence.
Email: info@benthamscience.net

Jamal Rafique

Instituto de Química, Universidade Federal do Mato Grosso do Sul

Author for correspondence.
Email: info@benthamscience.net

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