Indicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experiment

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

The article presents experimental data on the state of the antioxidant system in red blood cells of white outbred rats 1 and 3 months after acute mercury nitrate poisoning with a semilethal dose. It has been established that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, and an increase in the concentration of lipid peroxidation products).

It has been shown that the mercury content in the blood of experimental animals remains elevated during the entire study period.

The results obtained indicate the importance of impaired functioning of the antioxidant system in the implementation of long-term consequences of acute mercury poisoning. The reasons for the occurrence of these biochemical shifts and their role in the development of the long-term cytotoxic effects of mercury nitrate are discussed.

Авторлар туралы

E. Batotsyrenova

Institute of Toxicology of the Federal Medical Biological Agency;
Saint Petersburg State Pediatric Medical University

Хат алмасуға жауапты Автор.
Email: bkaterina2009@yandex.ru

Batotsyrenova Ekaterina Gennad’evna

192019, Saint Petersburg; 194100, Saint Petersburg

Ресей

O. Vakunenkova

Institute of Toxicology of the Federal Medical Biological Agency

Email: volga-2303@yandex.ru

Vakunenkova Olga Alexandrovna

192019, Saint Petersburg

Ресей

E. Zolotoverkhaya

Institute of Toxicology of the Federal Medical Biological Agency

Email: orzheskovskaya@mail.ru

Zolotoverkhaya Ekaterina Andreevna

192019, Saint Petersburg

Ресей

V. Kashuro

Institute of Toxicology of the Federal Medical Biological Agency

Email: kashuro@yandex.ru

Kashuro Vadim Anatolyevich

192019, Saint Petersburg

Ресей

T. Kostrova

Institute of Toxicology of the Federal Medical Biological Agency

Email: tasia.pcma.le4@mail.ru

Kostrova Taisia Alexandrovna

192019, Saint Petersburg

Ресей

L. Kubarskaya

Institute of Toxicology of the Federal Medical Biological Agency

Email: larkub@yandex.ru

Kubarskaya Larisa Georgyevna

192019, Saint Petersburg

Ресей

N. Lapina

Institute of Toxicology of the Federal Medical Biological Agency

Email: lapina2005@inbox.ru

Lapina Natalia Vadimovna

192019, Saint Petersburg

Ресей

K. Shchepetkova

Institute of Toxicology of the Federal Medical Biological Agency

Email: tesh_07@inbox.ru

Shchepetkova Kristina Mihailovna

192019, Saint Petersburg

Ресей

Әдебиет тізімі

  1. Lukovnikova L.V., Sidorin G.I., Alikbaeva L.A. Danger of acute and chronic poisoning with organic mercury compounds. Preventive and clinical medicine. 2013; 47 (2): 16-19 (in Russian).
  2. Malov A.M., Alexandrova M.L., Kashuro V.A., Ivanov M.B. Mercury contamination in Saint-Petersburg; Fundamental science and technology promising developments: proceedings of the Conference. 2016; 1-9 (in Russian).
  3. Golovko A. I., Kutsenko S. A., Ivnitsky Yu. Yu., Grebenyuk A. N., Ivanov M.B., Konoplin D.A. et al. Ecotoxicology: Textbook. Saint-Petersburg: Research Institute of Chemistry Saint-Petersburg State University; 1999 (in Russian).
  4. Golovko A. I., Kutsenko S. A., Ivnitsky Yu. Yu., Grebenyuk A. N., Ivanov M.B., Konoplin D.A. et al. Ecotoxicology: Textbook. Saint-Petersburg: Research Institute of Chemistry Saint-Petersburg State University; 1999 (in Russian).
  5. Artamonov V.G. Heavy metal lesions. In: Artamonov V.G., Shatalov N.N. Occupational diseases. Art M.: Medicine; 2006: 312 (in Russian).
  6. Artamonov V.G. Heavy metal lesions. In: Artamonov V.G., Shatalov N.N. Occupational diseases. Art M.: Medicine; 2006: 312 (in Russian).
  7. Malov A.M., Alexandrova M.L. Medical and environmental aspects of mercury contamination in a metropolis. Medline. ru. Russian Biomedical Journal. 2009; 10: 102-112 (in Russian).
  8. Malov A.M., Alexandrova M.L. Medical and environmental aspects of mercury contamination in a metropolis. Medline. ru. Russian Biomedical Journal. 2009; 10: 102-112 (in Russian).
  9. Golovko A.I., Ivanov MB, Reynyuk V.L., Vasiliev S.A., Batotsyrenov B.V., Lutsyk M.A. et al. Experimental Toxicology: Textbook. Saint-Petersburg .: Alby; 2012 (in Russian).
  10. Golovko A.I., Ivanov MB, Reynyuk V.L., Vasiliev S.A., Batotsyrenov B.V., Lutsyk M.A. et al. Experimental Toxicology: Textbook. Saint-Petersburg .: Alby; 2012 (in Russian).
  11. Shilov V.V., Chashchin V.P., Velikova V.D., Polozova E.V., Konstantinov R.V. Acute and chronic mercury poisoning (clinical presentation, diagnosis, prevention, treatment, examination). SPb.; 2006 (in Russian).
  12. Shilov V.V., Chashchin V.P., Velikova V.D., Polozova E.V., Konstantinov R.V. Acute and chronic mercury poisoning (clinical presentation, diagnosis, prevention, treatment, examination). SPb.; 2006 (in Russian).
  13. Shilov V.V., Lukin V.A., Savello V.E., Pivovarova L.P., Antonova A.M., Kashuro V.A. et al. Clinical observation of a patient after intravenous administration of elemental mercury for suicidal purposes. Toxicological Bulletin. 2015; 4: 44-48 (in Russian).
  14. Shilov V.V., Lukin V.A., Savello V.E., Pivovarova L.P., Antonova A.M., Kashuro V.A. et al. Clinical observation of a patient after intravenous administration of elemental mercury for suicidal purposes. Toxicological Bulletin. 2015; 4: 44-48 (in Russian).
  15. Luzhnikov EA, Sukhodolova G.N. Acute poisoning in adults and children. M.: Eksmo; 2009 (in Russian).
  16. Luzhnikov EA, Sukhodolova G.N. Acute poisoning in adults and children. M.: Eksmo; 2009 (in Russian).
  17. Lakhman O.L., Kolesov V.G., Andreeva O.K. et al. Problems of professional neurointoxication in modern conditions: Bull. scientific Council “Medical and environmental problems of workers”. 2003; 38-39 (in Russian).
  18. Lakhman O.L., Kolesov V.G., Andreeva O.K. et al. Problems of professional neurointoxication in modern conditions: Bull. scientific Council “Medical and environmental problems of workers”. 2003; 38-39 (in Russian).
  19. Sosedova L.M. Scientific and methodological foundations for modeling mercury toxic encephalopathy. Toxicological Bulletin. 2010; 1 (100): 21-25 (in Russian).
  20. Sosedova L.M. Scientific and methodological foundations for modeling mercury toxic encephalopathy. Toxicological Bulletin. 2010; 1 (100): 21-25 (in Russian).
  21. Malov A.M., Sibiryakov V.K., Mukovsky L.A., Semenov E.V. Mercury as a risk factor for human health. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. Social, humanities, biomedical sciences. 2014; 16 (2-5): 907-10 (in Russian).
  22. Malov A.M., Sibiryakov V.K., Mukovsky L.A., Semenov E.V. Mercury as a risk factor for human health. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. Social, humanities, biomedical sciences. 2014; 16 (2-5): 907-10 (in Russian).
  23. Kashuro V.A., Glushkov S.I., Kutsenko S.A., Karpishchenko A.I. et al. The state of the glutathione system in rat liver tissue in acute poisoning by cyclophosphamide Toxicological Bulletin. 2003: 25-30 (in Russian).
  24. Kashuro V.A., Glushkov S.I., Kutsenko S.A., Karpishchenko A.I. et al. The state of the glutathione system in rat liver tissue in acute poisoning by cyclophosphamide Toxicological Bulletin. 2003: 25-30 (in Russian).
  25. Kashuro V.A. Pathogenetic and diagnostic significance of the glutathione system in assessing the cytotoxic effect of antitumor drugs. Dr. med. sci. diss. SantPetersburg.; 2009 (in Russian).
  26. Kashuro V.A. Pathogenetic and diagnostic significance of the glutathione system in assessing the cytotoxic effect of antitumor drugs. Dr. med. sci. diss. SantPetersburg.; 2009 (in Russian).
  27. Soloviev N.D., Ivanenko N.B., Ivanenko A.A., Kashuro V.A. Determination of trace elements in biological fl by AACETA method with Zeeman background correction. Bulletin of OSU. 2011; 134 (15): 127-130 (in Russian).
  28. Soloviev N.D., Ivanenko N.B., Ivanenko A.A., Kashuro V.A. Determination of trace elements in biological fl by AACETA method with Zeeman background correction. Bulletin of OSU. 2011; 134 (15): 127-130 (in Russian).
  29. Malov A.M., Sibiryakov V.K., Kashuro V.A., Shemaev M.E., Schegholikhin D.K. Method for determination of mercury in biological materials. Patent for invention RU 2696958 (in Russian).
  30. Malov A.M., Sibiryakov V.K., Kashuro V.A., Shemaev M.E., Schegholikhin D.K. Method for determination of mercury in biological materials. Patent for invention RU 2696958 (in Russian).
  31. Kashuro V.A., Dolgo-Saburov V.B., Dagaev S.G., Batotsyrenova E.G., Kubarskaya L.G., Aksenov V.V. Study of the role of the antioxidant system and lipid peroxidation in the pathogenesis of thiopental coma. Chemical and biological safety. 2012; 3-7 (in Russian).
  32. Kashuro V.A., Dolgo-Saburov V.B., Dagaev S.G., Batotsyrenova E.G., Kubarskaya L.G., Aksenov V.V. Study of the role of the antioxidant system and lipid peroxidation in the pathogenesis of thiopental coma. Chemical and biological safety. 2012; 3-7 (in Russian).
  33. Karpishchenko A.I., ed. Medical laboratory technology: a guide to clinical laboratory diagnostics. V.1. M.: GEOTARMedia; 2012 (in Russian).
  34. Karpishchenko A.I., ed. Medical laboratory technology: a guide to clinical laboratory diagnostics. V.1. M.: GEOTARMedia; 2012 (in Russian).
  35. Kashuro V.A., Glushkov S.I., Karpishchenko A.I. , Novikova T.M., Minaeva L.V., Glushkova T.I. et al. The state of the glutathione system in the tissues of parenchymal organs of laboratory animals with repeated administration of cyclophosphamide. Nephrology. 2006; 10: 82-86 (in Russian).
  36. Kashuro V.A., Glushkov S.I., Karpishchenko A.I. , Novikova T.M., Minaeva L.V., Glushkova T.I. et al. The state of the glutathione system in the tissues of parenchymal organs of laboratory animals with repeated administration of cyclophosphamide. Nephrology. 2006; 10: 82-86 (in Russian).
  37. Malov A.M., Sibiryakov V.K., Semenov E.V. The effect of mercury on the content of free SH-groups in the blood plasma of rats and humans. Toxicological Bulletin. 2012; 3 (114): 20-24 (in Russian).
  38. Malov A.M., Sibiryakov V.K., Semenov E.V. The effect of mercury on the content of free SH-groups in the blood plasma of rats and humans. Toxicological Bulletin. 2012; 3 (114): 20-24 (in Russian).
  39. Malov A.M., Sibiryakov V.K., Semenov E.V. The effect of mercury on the content of free SH-groups in the blood plasma of rats and humans. Toxicological Bulletin. 2012; 3 (114): 20-24 (in Russian).
  40. Kashuro V.A., Karpishchenko A.I., Kutsenko S.A., Glushkov S.I. The possibility of using the definition of indicators of the glutathione system in the laboratory diagnosis of complications of course treatment with cyclophosphamide. Clinical laboratory diagnostics. 2002; (10): 43 (in Russian).
  41. Kashuro V.A., Karpishchenko A.I., Kutsenko S.A., Glushkov S.I. The possibility of using the definition of indicators of the glutathione system in the laboratory diagnosis of complications of course treatment with cyclophosphamide. Clinical laboratory diagnostics. 2002; (10): 43 (in Russian).
  42. Kashuro V.A., Karpishchenko A.I., Kutsenko S.A., Glushkov S.I. The possibility of using the definition of indicators of the glutathione system in the laboratory diagnosis of complications of course treatment with cyclophosphamide. Clinical laboratory diagnostics. 2002; (10): 43 (in Russian).
  43. Polushin Yu.S., Levshankov A.I., Lakhin R.E., Belozerova L.A., Ketskalo M.V. New possibilities for using the thiol antioxidant analyzer to evaluate the antioxidant system in severe patients and its further improvement. Scientific works of AMTN. 1996; 1: 210 216. (in Russian).
  44. Polushin Yu.S., Levshankov A.I., Lakhin R.E., Belozerova L.A., Ketskalo M.V. New possibilities for using the thiol antioxidant analyzer to evaluate the antioxidant system in severe patients and its further improvement. Scientific works of AMTN. 1996; 1: 210 216. (in Russian).
  45. Polushin Yu.S., Levshankov A.I., Lakhin R.E., Belozerova L.A., Ketskalo M.V. New possibilities for using the thiol antioxidant analyzer to evaluate the antioxidant system in severe patients and its further improvement. Scientific works of AMTN. 1996; 1: 210 216. (in Russian).
  46. Sears M.E. Chelation: Harnessing and enhancing heavy metal detoxification– a review. The Scientific World Journal. 2013; 13.
  47. Sears M.E. Chelation: Harnessing and enhancing heavy metal detoxification– a review. The Scientific World Journal. 2013; 13.
  48. Sears M.E. Chelation: Harnessing and enhancing heavy metal detoxification– a review. The Scientific World Journal. 2013; 13.
  49. Ynalvez R., Gutierrez J., Gonzalez-Cantu H. Mini-review: toxicity of mercury as a consequence of enzyme alteration. Biometals. 2016; 5: 781–788.
  50. Ynalvez R., Gutierrez J., Gonzalez-Cantu H. Mini-review: toxicity of mercury as a consequence of enzyme alteration. Biometals. 2016; 5: 781–788.
  51. Ynalvez R., Gutierrez J., Gonzalez-Cantu H. Mini-review: toxicity of mercury as a consequence of enzyme alteration. Biometals. 2016; 5: 781–788.
  52. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011; 15–16: 555–563.
  53. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011; 15–16: 555–563.
  54. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011; 15–16: 555–563.
  55. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.
  56. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.
  57. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.
  58. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.
  59. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.
  60. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.
  61. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.
  62. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.

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© Batotsyrenova E.G., Vakunenkova O.A., Zolotoverkhaya E.A., Kashuro V.A., Kostrova T.A., Kubarskaya L.G., Lapina N.V., Shchepetkova K.M., 2020


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